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Diss Factsheets
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EC number: 206-674-4 | CAS number: 366-18-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Not sensitising to skin (non guideline, Williamson 1972)
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A solution of the test item in DMF was applied over three days to the ears of four guinea pigs. Four days after the last induction, the flanks of the animals have been challenged with different concentrations of the test item. The skin reaction produced 24 h later was rated and compared to unsensitized controls.
method publication; Stevens MA, 1967
Use of the albino guinea-pig to detect the skin-sensitizing ability of chemicals
Br J Ind Med. 1967, 24(3):189-202; - GLP compliance:
- no
- Type of study:
- other: Study performed according to the method of Stevens (Br J Ind Med. 1967, 24(3):189-202)
- Species:
- guinea pig
- Strain:
- other: albino
- Sex:
- not specified
- Positive control results:
- no positive controls were reported.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item 2,2'-bipyridine was found not to be a strong sensitizer to skin in the ear-flank test according to Stevens (1967).
- Executive summary:
Skin sensitizing properties of the test item 2,2’-bipyridine were assessed according to the method of Stevens (Br J Ind Med. 1967, 24(3):189-202): the test item (dissolved in DMF) was applied over three days to the ears of four guinea pigs. Four days after the last induction, the flanks of the animals have been challenged with different concentrations of the test item. The skin reaction produced 24 h later was rated and compared to unsensitized controls.
After challenge of the shaved guinea pig flank with different concentrations of 2,2'-bipyridine in DMF, only the 10 % concentration produced erythema, whereas the 1.0 % and the 0.1 % solutions did not. As erythema were also observed in the 10 % group of unsensitized controls, it can be concluded that the observed reaction is due to potential skin irritating properties of 2,2'-bipyridine and that the test item is not a strong skin sensitizer.
Reference
After challenge of the shaved guinea pig flank with different concentrations of 2,2'-bipyridine in DMF, only the 10 % concentration produced erythema, whereas the 1.0 % and the 0.1 % solutions did not.
Erythema were also observed in the 10 % group of unsensitized controls.
It can therefore be concluded that the observed reaction is due to potential skin irritating properties of 2,2'-bipyridine and that the test item is not a skin sensitizer.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitizing properties of the test item 2,2’-bipyridine was assessed according to the method of Stevens (Br J Ind Med. 1967, 24(3):189-202): the test item (dissolved in DMF) was applied over three days to the ears of four guinea pigs. Four days after the last induction, the flanks of the animals have been challenged with different concentrations of the test item. The skin reaction produced 24 h later was rated and compared to unsensitized controls.
After challenge of the shaved guinea pig flank with different concentrations of 2,2'-bipyridine in DMF, only the 10 % concentration produced erythema, whereas the 1.0 % and the 0.1 % solutions did not. As erythema were also observed in the 10 % group of unsensitized controls, it can be concluded that the observed reaction is due to potential skin irritating properties of 2,2'-bipyridine and that the test item is not a strong skin sensitizer.
Justification for classification or non-classification
After challenge of the shaved guinea pig flank with different concentrations of 2,2'-bipyridine in DMF, only the 10 % concentration produced erythema, whereas the 1.0 % and the 0.1 % solutions did not. As erythema were also observed in the 10 % group of unsensitized controls, it can be concluded that the observed reaction is due to potential skin irritating properties of 2,2'-bipyridine and that the test item is not a strong skin sensitizer.
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