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EC number: 205-581-6 | CAS number: 143-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral LD50: 2875 mg/Kg (95% C.I: 2614 – 3162 mg/Kg).
Acute Dermal LD50: >2000 mg/Kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 875 mg/kg bw
- Quality of whole database:
- One key pre-guideline acute oral toxicity study in rats available for assessment.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Quality of whole database:
- One key Guideline (OECD 402) acute dermal toxicity study in rats available for assessment.
Additional information
Acute Oral Toxicity
In a key pre-guideline acute oral toxicity study, the test material was administered via intragastric intubation to Charles River CD rats (10 males/dose) at doses of 2250, 2630, 3020, 3400, or 5000 mg/Kg. Animals were observed for clinical signs and gross pathologic changes with surviving animals sacrificed 14 days post exposure.
Mortality was observed at each dose level as follows: 2250 mg/Kg (1/10); 2630 mg/Kg (2/10); 3020 mg/Kg (7/10); 3400 mg/Kg (8/10); 5000 mg/Kg (10/10). Clinical signs observed through the study period included pallor, discomfort, belly-crawling after dosing, weight loss for 1-2 days, diarrhoea, stained ventral area as well as hematuria observed at the two higher doses.
Dark bone marrow, hyperemic thymus, stomach and intestine distended with fluid, and hemorrhagic intestine and glandular mucosa of the stomach were observed in animals that died (5). In animals that survived (8), thickened stomach mucosa and, at higher dose levels, adhesion of the liver to the stomach were observed.
Based on mortality and clinical signs of toxicity as well as gross pathology observed in the study, the acute oral LD50 (calculated using the Litchfield and Wilcoxon method (1949)) was determined to be 2875 mg/Kg (95% C.I: 2614 – 3162 mg/Kg).
Acute Dermal Toxicity
In a key Guideline (OECD 402) acute dermal toxicity study, the test material was dermally administered to Sprague-Dawley rats (5/sex/dose) at a single dose of 2000 mg/Kg for a period of 24 hours under semi-occlusive conditions. Post exposure, the adhesive bandage and gauze patch were removed and the treated area (dorsal surface of the trunk of each anima) was cleaned by gentle swabbing of the skin with cotton wool soaked with lukewarm water. The animals were subsequently observed for a period of 14 days. On Day 15, all animals were sacrificed and subjected to gross necropsy examination for both external and internal abnormalities.
No mortality was observed through the study period. Slight to moderate scabs on the treatment site (dorsal region) were observed in several animals from Day 4. These had completely recovered by the end of the observation period in all animals, with the exception of three females (nos. 1, 3, and 7), that showed scabs on the treatment site also on the day of necropsy.
The body weight changes observed during the study were within the expected range for this species and age of animals. No significant abnormalities were found at necropsy in the animals at termination. Scabs in three female animals (nos. 1, 3 and 7) were observed at the treated site.
These results indicate that the test material has no toxic effects on the rat following dermal exposure over a 24 hour period at a dose level of 2000 mg/Kg. Based on the lack of mortality, the acute dermal LD50 was determined to be >2000 mg/Kg.
Acute Inhalation Toxicity
No studies were available for review. Exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size.
Justification for classification or non-classification
Not classified for acute toxicity by the oral or dermal routes of exposure under CLP Regulation (EC 1272/2008), section 3.1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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