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Diss Factsheets
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EC number: 204-653-4 | CAS number: 123-81-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- see II.2 Analysis of the Test Item Concentrations:
Four samples from the freshly prepared test media of all test concentrations and the control will be taken at the start of the test. For the determination of the stability of the test item under the test conditions and of the maintenance of the test item concentrations during the test period, four samples from the test media of all test concentrations and the control will be collected at the end of the test (after 48 hours) by pouring together the contents of the test beakers of each treatment - Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Species: Daphnia magna (Straus), clone 5. Age at Test Start: From 1.75 to 23.50 hours old Sex: Female Origin: The daphnids introduced in the test were taken from ibacon's in house laboratory culture. Breeding Conditions: The daphnids were bred in the laboratories of ibacon under similar temperature and light conditions as used in the test. The cultivation of the parental daphnids was performed in Elendt M4 medium (see 6.5). The test organisms were not first brood progeny. The daphnids in the stock culture were fed at least on all working days with green algae (Desmodesmus subspicatus) freshly grown in the laboratories of ibacon.
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 2.5 mmol/L (= 250 mg/L) as CaCO3
- Test temperature:
- Water temperature: 20.1 to 20.6 °C
- pH:
- pH value: 7.8 to 8.0
- Dissolved oxygen:
- dissolved oxygen concentration: 9.6 to 10.1 mg/L
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3.94 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.07 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 4.55 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Remarks:
- Control Immobilisation Rate: Was 0 % , no daphnid showed signs of disease or stress; thus the validity criterion was met. Dissolved Oxygen Concentration: Was ≥ 9.6 mg O2/L in in all treatment groups at the end of the test; the validity criterion was met.
- Conclusions:
- The toxic effect of the test item GDMA to Daphnia magna was
assessed in a semi-static concentration-response test. The 48-hour
NOEC was determined to be 2.07 mg test item/L. The 48-hour LOEC
was determined to be 4.55 mg test item/L and the 48-hour EC50 value
was calculated to be 3.94 mg test item/L.
The initial concentrations and the maintenance of the exposure
concentrations during the test were examined in the analytical part.
All reported results refer to nominal concentrations.
Reference
Table 1. Summary of Biological Results | ||
Nominal Concentration [mg test item/L] | % of immobilised daphnids after | |
24 hours | 48 hours | |
Control | 0 | 0 |
0.43 | 0 | 0 |
0.94 | 0 | 0 |
2.07 | 0 | 0 |
4.55 | 20 | 75 |
10 | 40 | 100 |
EC50 [mg test item/L]: 95 % CI [mg test item/L]: | > 10 n.d. | 3.94 3.46 - 4.42 |
EC20 [mg test item/L]: 95 % CI [mg test item/L]: | 6.08 3.51 - 8.27 | 3.10 2.46 - 3.52 |
EC10 [mg test item/L]: 95 % CI [mg test item/L]: | 4.09 1.48 - 5.77 | 2.64 1.93 - 3.09 |
NOEC [mg test item/L]: | 2.07 | 2.07 |
LOEC [mg test item/L]: | 4.55 | 4.55 |
Values refer to nominal test concentrations
CI: Confidence interval
n.d.: not determinable
Description of key information
The toxic effect of the test item GDMA to Daphnia magna was
assessed in a semi-static concentration-response test. The 48-hour
NOEC was determined to be 2.07 mg test item/L. The 48-hour LOEC
was determined to be 4.55 mg test item/L and the 48-hour EC50 value
was calculated to be 3.94 mg test item/L.
The initial concentrations and the maintenance of the exposure
concentrations during the test were examined in the analytical part.
All reported results refer to nominal concentrations.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 3.94 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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