Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Pyrithione zinc
  • IUPAC name: zinc(2+) bis(2-sulfanylidene-1,2-dihydropyridin-1-olate)
  • Other names
EC / List no.:
236-671-3
CAS no.:
13463-41-7
Index number:
Molecular formula:
C10H8N2O2S2Zn
SMILES:
[Zn++].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S
InChI:
InChI=1S/2C5H4NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4H;/q2*-1;+2
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
4
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the classification provided by companies to ECHA in CLP notifications this substance is toxic if swallowed, is very toxic to aquatic life, is toxic if inhaled, is very toxic to aquatic life with long lasting effects, causes damage to organs, causes serious eye damage, is suspected of damaging fertility or the unborn child, causes skin irritation and may cause an allergic skin reaction.

Breakdown of all 936 C&L notifications submitted to ECHA

Aquatic Acute 1 H400
Eye Dam. 1 H318
Acute Tox. 3 H301
Acute Tox. 3 H331
Acute Tox. 4 H332
Aquatic Chronic 1 H410
Acute Tox. 4 H302
Skin Irrit. 2 H315
STOT SE 1 H370
STOT RE 1 H372
Repr. 2 H361
Skin Sens. 1 H317
Acute Tox. 2 H310
Acute Tox. 2 H330
Eye Irrit. 2 H319
https://echa.europa.eu/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 16 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
This substance is approved for use as a Biocidal Active Substance
Biocidal Products:
There are 0 authorised Biocidal Product(s) that use this substance as an active ingredient

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 000 - 10 000 tonnes per year.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing and in manufacturing.

This substance is being reviewed for use as a biocide in the EEA and/or Switzerland, for: disinfection, product preservation, preservation films, preservation of fibres, leather, rubber, or polymers, preservation for construction materials, preventing fouling.

This substance is used in the following products: cosmetics and personal care products.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: cosmetics and personal care products and laboratory chemicals.

This substance is used in the following areas: scientific research and development and health services. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: laboratory work and hand mixing with intimate contact only with personal protective equipment available.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance and formulation of mixtures. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance is used in the following products: cosmetics and personal care products and biocides (e.g. disinfectants, pest control products).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, laboratory work, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, mixing in open batch processes and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: use only outdoors or in a well-ventilated area; do not eat, drink or smoke when using this product; avoid release to the environment; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. Immediately call a poison center or doctor/physician. Collect spillage. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. Rinse the mouth. Call a poison center or doctor/physician.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Arch UK Biocides Ltd (OR4), Wheldon Rd WF10 2JT Castleford United Kingdom
  • ARCH UK BIOCIDES LTD (M/I), WHELDON RD WF10 2JT CASTLEFORD WEST YORKSHIRE United Kingdom
  • ARCH UK BIOCIDES LTD (OR1), WHELDON RD WF10 2JT CASTLEFORD WEST YORKSHIRE United Kingdom
  • BCS Only Representative Services Ltd, Pembroke House 30 Upper Pembroke Street Dublin 2 Dublin Ireland
  • Janssen Pharmaceutica N.V., Turnhoutseweg 30 2340 Beerse Belgium
  • Jubilant Lifesciences NV, Axxes Business Park - Guldensporenpark 22 - block C 9820 Merelbeke Belgium
  • KUMAR ORGANIC PRODUCTS LIMITED, 3 , St.Mary’s Road, LU1 3JA Luton Bedfordshire United Kingdom
  • Lonza Cologne GmbH, Nattermannallee 1 50829 Cologne Germany
  • Procter & Gamble Amiens S.A.S., 163/165 quai Aulagnier 92600 ASNIERES SUR SEINE France
  • Procter & Gamble Blois S.A.S., 163/165 quai Aulagnier 92600 ASNIERES SUR SEINE France
  • Procter & Gamble Manufacturing Belgium N.V., Temselaan 100 1853 Strombeek-Bever Belgium
  • Procter & Gamble Product Supply (U.K.) Limited, The Heights, Brooklands KT13 OXP Weybridge, Surrey United Kingdom
  • Procter & Gamble Sverige Aktiebolag, Box 27303 10254 STOCKHOLM Sweden
  • Procter & Gamble – Rakona s.r.o., Ottova 402 269 32 Rakovnik Czech Republic
  • Procter and Gamble Operations Polska Sp. z o. o., Zabraniecka Street 20 03-872 Warsaw Poland
  • RSI ChemRep Europe Ltd (K002), 27-30 Merchants Quay Merchants House 8 Dublin Ireland

Other names

  • -
  • 1-oxidopyridine-6-thiolate, zinc (II) cation
  • 2-Mercaptopyridine N-Oxide Zinc Salt
  • Bis [1-hydroxy-2(1H)-pyridinethionato-O,S](T-4)-zinc
  • bis(1-hydroxy-2(1h)-pyridinethionato)zinc
  • bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-(T-4) zinc
  • Bis(1-hydroxy-2(1H)-pyridinthionato-O,S) zinc
  • bis(2-pyridylthio)zinc 1,1'-dioxide
  • bis[1-hydroxy-2-(1H)-pyridine-thionato]zinc
  • Kopthione Zn
  • Mercaptopyridine N-oxide zinc salt, Pyrithione
  • Mercaptopyridine N-oxidezinc salt
  • Pyrithione zinc
  • pyrithione zinc`
  • Zinc 1-oxidopyridin-1-ium-2-thiolate
  • Zinc 2-pyridinethiol-1-oxide
  • zinc bis(2-thioxopyridin-1(2H) -olate)
  • zinc bis(2-thioxopyridin-1(2H)-olate)
  • Zinc pyridinethione
  • Zinc pyrithion
  • Zinc Pyrithione
  • zinc(2+) bis(2-sulfanylidene-1,2-dihydropyridin-1-olate)
  • ZINC, BIS(1-HYDROXY-2(1H)-PYRIDINETHIONATO)- (6CI,7CI,8CI)
  • zinc;1-oxidopyridin-1-ium-2-thiolate
  • Pyrithione zinc
  • Pyrithione zinc (Zinc pyrithione)
  • Zinc pyrithione
  • Zinc Pyrithione

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Powder (100%) [1]
C Odour
Odourless (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Melting/freezing point

Study results
  • 2 studies submitted
  • 1 study processed
R Melting / freezing point
267 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Boiling point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Density

Study results
  • 2 studies submitted
  • 1 study processed
R Density
1.76 g/cm³ @ 20.1 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Vapour pressure

Study results
  • 2 studies submitted
  • 1 study processed
R Vapour pressure
0 Pa @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Partition coefficient

Study results
  • 2 studies submitted
  • 1 study processed
R Log Pow
0.9 @ 25 °C and pH 7.5 - 7.7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Water solubility

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Solubility in organic solvents / fat solubility

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Surface tension

Study results
  • 2 studies submitted
  • 1 study processed
R Surface tension
73 mN/m @ 7.22 mg/L and 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flammability

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Hydrolysis

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life for hydrolysis
3.6 months @ 25 °C

Phototransformation in water

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water - screening tests

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Inherently biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
1.4

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Adsorption/desorption

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 1 study submitted
  • 1 study processed
R H - (pressure) m³/mol
0 Pa m³/mol [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Distribution modelling

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 90 ng/L (1)
Intermittent releases (freshwater) -
Marine water 90 ng/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 10 µg/L (1)
Sediment (freshwater) 9.5 µg/kg sediment dw (1)
Sediment (marine water) 9.5 µg/kg sediment dw (1)
Hazard for Air
Air -
Hazard for Terrestrial Organism
Soil 1.02 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 13 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 2.6 - 400 µg/L [2]
LC0 (4 days) 1.1 - 200 µg/L [2]
LC100 (4 days) 7.9 - 590 µg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 11
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
2.6 µg/L
LC50 for marine water fish
400 µg/L

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (28 days) 1.22 µg/L [1]
LOEC (28 days) 2.82 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 14 studies submitted
  • 2 studies processed
P/RResults
EC50 (4 days) 6.3 µg/L [1]
EC50 (48 h) 8.2 µg/L [1]
EC0 (4 days) 1.6 µg/L [1]
EC0 (48 h) 1.1 µg/L [1]
EC100 (4 days) 9.4 µg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 12
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
8.2 µg/L
EC50 / LC50 for marine invertebrates
6.3 µg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
NOEC (28 days) 2.28 µg/L [1]
NOEC (21 days) 2.7 - 22 µg/L [5]
LOEC (28 days) 4.2 µg/L [1]
LOEC (21 days) 5.8 - 49 µg/L [5]
EC50 (28 days) 5.21 µg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
2.2 µg/L
EC10 / LC10 or NOEC for marine invertebrates
2.28 µg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 8 studies submitted
  • 1 study processed
P/RResults
EC50 (5 days) 1.2 µg/L [1]
EC50 (4 days) 1.3 µg/L [1]
NOEC (5 days) 460 ng/L [1]
NOEC (4 days) 460 ng/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
3 µg/L
EC50 for marine water algae
1.2 µg/L
EC10 or NOEC for freshwater algae
2.4 µg/L
EC10 or NOEC for marine water algae
460 ng/L

Toxicity to aquatic plants other than algae

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (7 days) 9.6 µg/L [1]
LOEC (7 days) 8.6 µg/L [1]
EC0 (7 days) 4 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to microorganisms

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EC50 (3 h) 2.4 mg/L [1]
EC50 (30 min) 5.8 mg/L [1]
NOEC (3 h) 100 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
2.4 mg/L
EC10 or NOEC for microorganisms
100 µg/L

Sediment toxicity

Study results
  • 5 studies submitted
  • 1 study processed
P/RResults
EC50 (10 days) 2.1 mg/kg sediment dw [1]
EC0 (10 days) 950 µg/kg sediment dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater sediment
2.1 mg/kg sediment dw
EC10 / LC10 or NOEC for freshwater sediment
950 µg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (28 h) 250 - 500 mg/kg soil dw [2]
EC50 (28 h) 670 mg/kg soil dw [1]
LC50 (28 h) 822 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (28 days) 10.24 mg/kg soil dw [1]
EC10 (28 days) 10.35 mg/kg soil dw [1]
EC50 (28 days) 89.68 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
LD50 (14 days) 60 mg/kg bw [1]
NOEL (14 days) 31.2 mg/kg bw [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: - -
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 10 µg/kg bw/day carcinogenicity
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
EYE Exposure
-
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: - -
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: - -
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: - -
Acute /short term: - -
EYE Exposure
-

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Dermal: 0.41 %

Acute toxicity

Study results
oral
  • 3 studies submitted
  • 1 study processed
P/RResults
LD50 221 - 302 mg/kg bw (rat) [3]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 2 studies submitted
  • 1 study processed
P/RResults
LD50 2 000 mg/kg bw (rat) [1]

dermal
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: eye
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: respiratory
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 7 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 0.5 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 2 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 2 mg/m³ air [1]
LOAEL (rat): 6 mg/m³ air [1]

Study data: inhalation
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 2 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 100 mg/kg bw/day [1]
LOAEL (rat): 1 000 mg/kg bw/day [1]

Study data: dermal
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant