Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
227-813-5
CAS no.:
5989-27-5
Index number:
601-096-00-2
Molecular formula:
C10H16
SMILES:
CC(=C)[C@@H]1CCC(C)=CC1
InChI:
InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3/t10-/m0/s1
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
29
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP17) approved by the European Union, this substance may be fatal if swallowed and enters airways, is very toxic to aquatic life, is a flammable liquid and vapour, is harmful to aquatic life with long lasting effects, causes skin irritation and may cause an allergic skin reaction.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is very toxic to aquatic life with long lasting effects.

Breakdown of all 2933 C&L notifications submitted to ECHA

Flam. Liq. 3 H226 Harmonised Classification
Skin Irrit. 2 H315 Harmonised Classification
Aquatic Acute 1 H400 Harmonised Classification
Skin Sens. 1 H317
Aquatic Chronic 1 H410
Asp. Tox. 1 H304 Harmonised Classification
Aquatic Chronic 3 H412 Harmonised Classification
Skin Sens. 1B H317 Harmonised Classification
Eye Irrit. 2 H319
Aquatic Chronic 2 H411
Acute Tox. 4 H312
Acute Tox. 4 H332
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).
  • PBT
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Persistent, Bioaccumulative and Toxic (3.03% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 62 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: washing & cleaning products, biocides (e.g. disinfectants, pest control products), air care products and polishes and waxes.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid and outdoor use.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)), indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints), indoor use as processing aid and outdoor use as processing aid.

This substance is intended to be released from scented: clothes, toys and paper products.

This substance is used in the following products: washing & cleaning products, biocides (e.g. disinfectants, pest control products), perfumes and fragrances and cosmetics and personal care products.

This substance is used in the following areas: formulation of mixtures and/or re-packaging.

This substance is used in the following activities or processes at workplace: transfer of chemicals, roller or brushing applications, non-industrial spraying, batch processing in synthesis or formulation with opportunity for exposure and closed, continuous processes with occasional controlled exposure.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: perfumes and fragrances, biocides (e.g. disinfectants, pest control products), cosmetics and personal care products, washing & cleaning products and water treatment chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, laboratory work, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: perfumes and fragrances, biocides (e.g. disinfectants, pest control products), cosmetics and personal care products, washing & cleaning products and air care products.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, batch processing in synthesis or formulation with opportunity for exposure, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, industrial spraying, laboratory work and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, for thermoplastic manufacture, as processing aid, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates) and of substances in closed systems with minimal release.

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, transfer of chemicals, closed processes with no likelihood of exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. Do not induce vomiting. If skin irritation or a rash occurs: get medical advice/attention. If on skin: wash with soap and water.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL (OR1), Hermeslaan 7 1831 Diegem Belgium
  • 3M Deutschland GmbH, Carl-Schurz-Strasse 1 41453 Neuss Germany
  • 3M Wroclaw Sp.z.o.o., ul. Kowalska 143 51-424 Wroclaw Poland
  • ADM WILD Europe GmbH & Co. KG, Rudolf-Wild-Strasse 107-115 69214 Eppelheim Baden-Württemberg Germany
  • ALFARIN QUIMICA, S.A., C/. Ibiza 35 -5º C 28009 MADRID Spain
  • Associate Allied Chemicals Europe, ZI DES BOIS DE GRASSE 37 AVENUE LOUISON BOBET 06130 Grasse France
  • Bell Flavors & Fragrances GmbH, Schimmelstr. 1 04205 Leipzig Germany
  • BERNARDI, Parc Industriel Les Bois de Grasse Avenue Michel Chevalier 06130 GRASSE France
  • BONTOUX S.A.S., Le clôt 26170 Saint Auban sur l'Ouvèze France
  • BORDAS SAS, 1 Bis Rue Emile Zola L 'Algav 13170 Les Pennes Mirabeau France
  • Bostik Nederland B.V._01, Zeggeveld #10 RP4705 Roosendaal Netherlands
  • Chemours Netherlands B.V., Baanhoekweg 22 3313 LA Dordrecht Netherlands
  • CITRICOS DEL ANDEVALO S.A., Camino de Lepe, S/N 21540 Huelva Spain
  • Claus Nitsche & Sohn GmbH, Billbrookdeich 122 22113 Hamburg Germany
  • COINTREAU, CARREFOUR MOLIERE 49124 SAINT BARTHELEMY D'ANJOU France
  • Cytec Industries BV, Weena 505 3013 AL Rotterdam Netherlands
  • Dako Denmark ApS, Produktionsvej 42 2600 Glostrup Denmark
  • DESTILACIONES BORDAS CHINCHURRETA, S.A., C/ Acueducto, 4-6 Pol. Ind. Ctra la Isla 41703 Dos Hermanas (Sevilla) Spain
  • DRT OR FOR PINOVA, 30 rue Gambetta BP 206 40105 Dax France
  • ECSA ITALIA SRL con Unico Socio, Via Lav. Autobianchi, 1 I-20832 Desio (MB) Lombardia Italy
  • ERNESTO VENTOS, S.A., Carretera Reial 120B 08960 Sant Just Desvern Spain
  • European Refreshments Unlimited Company, Southgate Dublin Road A92 YK7W Drogheda Meath Ireland
  • FIRMENICH GRASSE SAS OR 1, Parc Industriel Les Bois de Grasse 06130 Grasse France
  • FIRMENICH GRASSE SAS OR 3, Parc Industriel Les Bois de Grasse 06130 Grasse France
  • FIRMENICH GRASSE SAS OR 8, Parc Industriel Les Bois de Grasse 06130 Grasse France
  • Frey + Lau GmbH, Immenhacken 12 DE-24558 Henstedt-Ulzburg Germany
  • FSZ POLLENA AROMA SP. Z O.O., Przemysłowa 14 05-100 Nowy Dwór Mazowiecki mazowieckie Poland
  • Givaudan France SAS - OR14, 55, Rue de la voie des Bans 95102 Argenteuil Cedex France
  • Globalab I+D, S.L., Avenida Visley nº 7 11407 Jerez de la Frontera Cadiz Spain
  • H. REYNAUD & FILS, La Cheminade 26570 MONTBRUN LES BAINS France
  • IBERCHEM, S.A, Polígono Industrial Oeste P.9/9 30820 ALCANTARILLA MURCIA Spain
  • IFF Benicarlo, S.L., Avda. Felipe Klein 2 12580 Benicarlo Castellon Spain
  • IFF OR NL2, International Flavors & Fragrances I.F.F. (Nederland) B.V. Liebergerweg 72-98 1221JT Hilversum Noord-Holland Netherlands
  • International Flavors & Fragrances I.F.F. (Nederland) B.V., Liebergerweg 72-98 1221 JT Hilversum Netherlands
  • Intertek Deutschland GmbH 33, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Kraton Chemical AB OR1, Massvagen 15 P.O. Box 66 SE-820 22 Sandarne Sweden
  • Leica Biosystems Nussloch GmbH, Heidelberger Straße 17-19 69226 Nussloch Germany
  • LES DERIVES RESINIQUES ET TERPENIQUES, 30 rue Gambetta B.P. 206 40105 Dax Cedex France
  • LLUCH ESSENCE, S.L.U., Lo Gaiter, 160 08820 EL PRAT DE LLOBREGAT CATALUÑA Spain
  • MCI Miritz Citrus GmbH & Co. KG, Citrusstraße 3 37318 Kirchgandern Germany
  • Novachem Aromatici S.r.L., V.Carlo Noè, 7 21013 Gallarate Varese Italy
  • PeelPioneers B.V., Jacob van Lennepstraat 235 C 1053 JC Amsterdam Netherlands
  • PRODALIM B.V., Binnenvenstraat 5 1911 TK Uitgeest Netherlands
  • PRODASYNTH, PI DES BOIS DE GRASSE 4 AV. JOSEPH HONORE ISNARD 06130 GRASSE France
  • Quimimont SLU, C/ Llobregat 6, Polígono Industrial Can Bernades-Subirà 08130 Santa Perpètua de Mogoda Barcelona Spain
  • Ramboll Belgium bvba, 46 Meersbloem-Melden 9700 Oudenaarde Belgium
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • Refresco Iberia S.A.U., Carretera N-332, Km. 206,9 46780 Oliva Valencia Spain
  • Roche Diagnostics GmbH, Sandhoferstrasse 116 68305 Mannheim Germany
  • SAT 1596 NUFRI, Carretera de Palau Km 1 25230 Mollerussa Lérida Spain
  • SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium
  • Sensient Technologies Europe GmbH, Geesthachter Straße 103 21502 Geesthacht Germany
  • Symrise AG, Mühlenfeldstraße 1 37603 Holzminden Germany
  • Symrise Granada, S.A.U., Crta. Armilla Km 2,5 18100 Armilla Granada Spain
  • TAKASAGO TEPL-Importer, 12 rue Torricelli 75017 Paris France
  • TAKASAGO TEPL-OR(7), 12 rue Torricelli 75017 Paris France
  • V. MANE FILS , 620 route de Grasse 06620 Le Bar sur Loup France
  • Vantage Specialty Chemicals, 3 rue Jules Guesde 91130 RIS ORANGIS France
  • Weissmeer Baltische Import-Export GmbH, Colonnaden 51 20354 Hamburg Germany
  • ZUMOS PALMA S.L.U., Polígono Industrial Mataché 18-53 14700 Palma del Rio Córdoba Spain
  • ZUMOS VALENCIANOS DEL MEDITERRÁNEO S.A., C/ del Pollancar s.n. P.I.Parc Sagunt I 46520 Sagunto Valencia Spain
  • [Confidential], [Confidential]
  • Augustus Oils Ltd, Augustus House Mill Lane GU34 2QG Alton Hampshire United Kingdom
  • CITROSUCO SPAIN, S.L.U., POLIGONO INDUSTRIAL MATACHE, PARCELA 18-53 14700 PALMA DEL RIO CORDOBA Spain
  • INTERTEK FRANCE, ZAC Ecoparc II 27400 HEUDEBOUVILLE France
  • KiK Textilien und Non-Food GmbH, Siemensstrasse 21 59199 Boenen Germany

Substance names and other identifiers

(d)-Limonene
Other
(R)-p-mentha-1,8-diene
EC Inventory, REACH pre-registration
(R)-p-Mentha-1,8-diene
REACH pre-registration, Cosmetic Products Regulation, Annex III - Restricted Substances
(R)-p-mentha-1,8-diene; d-limonene
Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
D-Limonene
Cosmetic Products Regulation, Annex III - Restricted Substances, Annex of Approved Active Substances for Plant Protection Products, Annex II, Sec III - Allergenic Fragrances Banned/Restricted in Toys
Orange oil
Statistics on Pesticides Regulation - Annex III Harmonized C&L
(+)-Limonene
C&L Inventory
(+)-Limonene; (+)-(4R)-Limonene; (+)-carvene ...
C&L Inventory
(+)-p-Mentha-1,8-dien
C&L Inventory
(4R)-(+)-1-methyl-4-prop-1-en-2-ylcyclohexene
C&L Inventory
(4R)-1-Methyl-4-(1-methylethenyl)cyclohexene
C&L Inventory
(4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene
C&L Inventory, Registration dossier, Other
(4R)-1-methyl-4-(prop-1-en-2-yl)cyclohexane
Registration dossier
(4R)-1-methyl-4-(prop-1-en-2-yl)cyclohexene
C&L Inventory, Registration dossier
(4R)-1-methyl-4-prop-1-en-2-ylcyclohexene
C&L Inventory, Other
(4R)-4-Isopropenyl-1-methylcyclohexene
C&L Inventory
(4R)-isopropenyl-1-methylcyclohexene
C&L Inventory, Registration dossier
(R)-(+)-Limonen
C&L Inventory
(R)-(+)-para-mentha-1,8-diene
C&L Inventory
(R)-1-methyl-4-(1-methylethenyl)-cyclohexene
C&L Inventory
(R)-4-Isopropenyl-1-methyl-1-cyclohexene
C&L Inventory
(R)-4-Isopropenyl-1-methylcyclohexene
C&L Inventory
(R)-p-menta-1,8-dien
C&L Inventory
(R)-p-Mentha-1,8-dien
C&L Inventory
(R)-P-MENTHA-1,8-DIENE
C&L Inventory, Registration dossier
(R)-p-mentha-1,8-diene
C&L Inventory, Registration dossier
(R)-p-mentha-1,8-diene ; d-limonene
C&L Inventory
(S)-p-mentha-1,8-diene
C&L Inventory
1-methyl-4(prop-1-en-2-yl)-cyclonexene
C&L Inventory
1-Methyl-4-(1-methylethenyl)-cyclohexene
C&L Inventory
1-methyl-4-([1R]-methylethenyl)-cyclohexene
C&L Inventory
1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene
C&L Inventory
1-Methyl-4-prop-1-en-2-ylcyclohexene
C&L Inventory
1-méthyl-4-prop-1-èn-2-yl-cyclohexène
C&L Inventory
4-Isopropenyl-1-methylcyclohexene
C&L Inventory, Registration dossier
4-isopropenyl-1-methylcyclohexene 
C&L Inventory
4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene
Registration dossier
BITTER ORANGE E.O.
Registration dossier
CYCLOHEXEN,1-METHYL-4-(1-METHYLETHENYL)-,(R)
C&L Inventory
Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (4R)-
C&L Inventory, Registration dossier
Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-
C&L Inventory
Cyclohexene,1-methyl-4-(1-methylethenyl)-,(r)
C&L Inventory
D'-limonene
C&L Inventory
D-LIMONENE
C&L Inventory, Registration dossier
D-LIMONENE
C&L Inventory, Registration dossier
d-limonene (R)-p-mentha-1,8-diene
C&L Inventory
D-Limoneno
Registration dossier
d-limonén
C&L Inventory
d_limonene
Registration dossier
Limonene
C&L Inventory
Limonene
C&L Inventory, Registration dossier
LIMONENE, D-
Registration dossier
ORANGE OILORANGE BRAZIL OILCITRUS TERPENES
Registration dossier
R)-p-mentha-1,8-diene
C&L Inventory
R)-p-mentha-1,8-diene, D-Limonene
C&L Inventory
r-p-mentha-1,8-dien
C&L Inventory
Aceite d-Limoneno de Naranja
Registration dossier
Citrus Terpenes
Registration dossier
Citrusterpene
Registration dossier
CLEARON M105
Registration dossier
CLEARON P105
Registration dossier
CLEARON P125
Registration dossier
Cold Pressed Peel Oil
Registration dossier
D'Limonene
Registration dossier
D-Limonen
Registration dossier
D-Limonene
C&L Inventory, Registration dossier
D-LIMONENE BRAZIL
Registration dossier
LIMONENE-D
C&L Inventory
NANOLET R1050-CH
Registration dossier
ORANGE TERPENES
Registration dossier
Piccolyte C115
Registration dossier
Piccolyte C125
Registration dossier
Piccolyte C85
Registration dossier
Piccolyte HM106 ULTR
Registration dossier
Piccolyte S115
Registration dossier
YS RESIN PX1150
Registration dossier
YS RESIN TO-L
Registration dossier
YS RESIN TO105
Registration dossier
YS RESIN TO115
Registration dossier
YS RESIN TO125
Registration dossier
YS RESIN TR105
Registration dossier
(R)-p-Mentha-1,8-diene
REACH pre-registration
Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (4R)-
REACH pre-registration
1051930-86-9
CAS number
Other
5989-27-5
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex III - Restricted Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Statistics on Pesticides Regulation - Annex III Harmonized C&L, Annex of Approved Active Substances for Plant Protection Products, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Annex II, Sec III - Allergenic Fragrances Banned/Restricted in Toys, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
601-096-00-2
Index number
C&L Inventory
68606-81-5
CAS number
C&L Inventory
7705-13-7
CAS number
Other
94765-75-0
CAS number
Other
95327-98-3
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 3 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Form
Liquid (100%) [1]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 2 studies submitted
  • 1 study processed
R Melting / freezing point
-73.97 - -73.65 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-74 °C

Boiling point

Study results
  • 7 studies submitted
  • 3 studies processed
R Boiling point
175.5 - 176.5 °C @ 101.725 kPa [3]

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence 5
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
176 °C

Density

Study results
  • 7 studies submitted
  • 1 study processed
R Relative density
0.844 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
0.844

Vapour pressure

Study results
  • 4 studies submitted
  • 1 study processed
R Vapour pressure
2 hPa @ 24.85 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
2 hPa @ 25 °C

Partition coefficient

Study results
  • 3 studies submitted
  • 1 study processed
R Log Pow
4.38 @ 37 °C and pH 7.2 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
4.38 @ 25 °C

Water solubility

Study results
  • 5 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
5.69 - 12.3 mg/L @ 20 - 25 °C and pH 5 - 7 [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
5.69 mg/L @ 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 3 studies submitted
  • 1 study processed
R Flash point
51 °C @ 101.325 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
51 °C

Auto flammability

Study results
  • 2 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
245 °C @ 99.544 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
245 °C

Flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 2 studies submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
0.846 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Dynamic viscosity at 20 °C
0.846 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 7 studies submitted
  • 2 studies processed
C Interpretation of results
Readily biodegradable (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 3 2
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
690.1 L/kg ww

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 3 studies submitted
  • 3 studies processed
R Koc
1 120 - 6 324 L/kg [3]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
2 413

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 14 µg/L (1)
Intermittent releases (freshwater) -
Marine water 1.4 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 1.8 mg/L (1)
Sediment (freshwater) 3.85 mg/kg sediment dw (1)
Sediment (marine water) 385 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 763 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 133 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 3 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 days) 460 - 720 µg/L [3]
EC50 (4 days) 688 - 702 µg/L [2]

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (28 days) 80 µg/L [1]
NOEC (8 days) 59 - 370 µg/L [3]
LOEC (8 days) 190 - 670 µg/L [3]
EC10 (8 days) 370 - 670 µg/L [1]
LC10 (8 days) 320 µg/L [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
EC50 (48 h) 307 - 510 µg/L [2]
EC50 (24 h) 840 µg/L [1]
EC10 (48 h) 420 µg/L [1]
EC10 (24 h) 450 µg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 3 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 50 - 80 µg/L [2]
LOEC (21 days) 173 µg/L [1]
EC10 (21 days) 153 µg/L [1]
EC50 (21 days) 188 µg/L [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
EC50 (72 h) 214 - 320 µg/L [2]
EC50 (48 h) 250 µg/L [1]
NOEC (48 h) 90 µg/L [1]
EC10 (72 h) 149 - 174 µg/L [2]
EC10 (48 h) 140 µg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
320 µg/L
EC10 or NOEC for freshwater algae
174 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EC50 (3 h) 209 mg/L [1]
EC10 (3 h) 18 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
209 mg/L
EC10 or NOEC for microorganisms
18 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 66.7 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 9.5 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 16.6 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4.8 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4.8 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 100 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 9 studies submitted
  • 1 study processed
P/RResults
LD50 2 000 mg/kg bw (rat) [1]
M/CInterpretations of results
Not classified [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 5 3
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
dermal
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

dermal
Studies with data
Key study
Supporting study 1
Weight of evidence 2
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 2 000 mg/kg bw
Dermal route:
No adverse effect observed LD50 5 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 2 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 9 studies submitted
  • 5 studies processed
P/RResults
NOAEL (rat): 600 - 1 650 mg/kg bw/day [4]
NOAEL (mouse): 500 - 1 650 mg/kg bw/day [2]
NOAEL (dog): 100 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 5
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed LOAEL 1 000 mg/kg bw/day (subchronic, dog)

Genetic toxicity

Study results
Study data: in vitro
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 4
Supporting study 2 1
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LOAEL 75 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 1
Data waiving
no waivers
Study data: developmental
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 591 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant