Previous Testing Proposals
Previous Testing Proposals
| 1-(4-(ACETYLOXY)-3-((ACETYLOXY)METHYL)PHENYL)ETHANONE | 921-042-4 | - | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 |
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Details |
| 2,4,6,8,10-pentamethylcyclopentasiloxane | 228-204-7 | 6166-86-5 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 2,4,6,8-tetramethylcyclotetrasiloxane (EC 219-137-4) | 25/05/2020 | 09/07/2020 | Details | |
| 2,4,6,8-tetramethylcyclotetrasiloxane | 219-137-4 | 2370-88-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/05/2020 | 09/07/2020 | Details | |
| 4,4'-isopropylidenedi-o-cresol | 201-240-0 | 79-97-0 | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
| [1,3-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide | 218-664-7 | 2212-81-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with [1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide CAS: 25155-25-3)” | 25/05/2020 | 09/07/2020 | Details | |
| Choline hydroxide | 204-625-1 | 123-41-1 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Choline chloride (EC 200-655-4) | 25/05/2020 | 09/07/2020 | Details | |
| Dichlorobis(η-cyclopentadienyl)titanium | 215-035-9 | 1271-19-8 | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
| Dimethoxymethylsilane | 240-914-9 | 16881-77-9 | Sub-chronic toxicity (90-day): oral | 25/05/2020 | 09/07/2020 | Details | |
| hexadecyltrimethoxysilane | 240-464-3 | 16415-12-6 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/05/2020 | 09/07/2020 | Details | |
| Lithium phosphorodifluoridate | 643-080-8 | 24389-25-1 | Reproductive toxicity (pre-natal developmental toxicity) | 25/05/2020 | 09/07/2020 | Details | |
| Lithium tetrafluoroborate, anhydrous | 238-178-9 | 14283-07-9 | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
| N-(2-hydroxyethyl)-N-[2-[(1-oxooctyl)amino]ethyl]-β-alanine | 264-761-2 | 64265-45-8 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Amphoacetates C8-C18 (EC 931-291-0) || Note: Testing proposal is based on concern identified by the registrant. | 25/05/2020 | 09/07/2020 | Details | |
| p-tert-butylstyrene | 217-126-9 | 1746-23-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. | 25/05/2020 | 09/07/2020 | Details | |
| Phosphoric acid, 2-ethylhexyl ester | 235-741-0 | 12645-31-7 | Reproductive toxicity (pre-natal developmental toxicity) | 25/05/2020 | 09/07/2020 | Details | |
| Platinum(IV) aqua hydroxo nitrato complexes | 701-319-4 | - | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
| Platinum, 1,3-diethenyl-1,1,3,3-tetramethyldisiloxane complexes | 701-315-2 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. | 25/05/2020 | 09/07/2020 | Details | |
| Reaction mass of 4,4,13,13-tetraethoxy-3,14-dioxa-8,9-dithia-4,13-disilahexadecane and 4,4,14,14-tetraethoxy-3,15-dioxa-8,9,10-trithia-4,14-disilaheptadecane | 915-748-1 | - | Sub-chronic toxicity (90-day): oral || Note: testing proposed with polysulfides, bis[3-(triethyoxysilyl)propyl (CAS No 211519-85-6) | 25/05/2020 | 09/07/2020 | Details | |
| Reaction mass of sodium 1-methoxy-1-oxohexadecane-2-sulphonate and sodium methyl 2-sulphooctadecanoate | 911-616-2 | - | Sub-chronic toxicity (90-day): oral | 25/05/2020 | 09/07/2020 | Details | |
| Sodium 1-hydroxyethanesulphonate | 213-037-4 | 918-04-7 | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
| triethoxy(methyl)silane | 217-983-9 | 2031-67-6 | Sub-chronic toxicity (90-day): oral | 25/05/2020 | 09/07/2020 | Details | |
| Zinc bis(benzenesulphinate) | 246-148-1 | 24308-84-7 | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
| Distillates (petroleum), hydrodesulfurized middle | 265-183-3 | 64742-80-9 | Genetic toxicity in vivo | 14/05/2020 | 29/06/2020 | Details | |
| Distillates (petroleum), hydrotreated middle | 265-148-2 | 64742-46-7 | Genetic toxicity in vivo | 14/05/2020 | 29/06/2020 | Details | |
| Gas oils (petroleum), hydrodesulfurized | 265-182-8 | 64742-79-6 | Genetic toxicity in vivo | 14/05/2020 | 29/06/2020 | Details | |
| Benzyldimethylamine | 203-149-1 | 103-83-3 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
23/03/2020 23/03/2020 23/03/2020 |
07/05/2020 07/05/2020 07/05/2020 |
Details | |
| (octahydro-4,7-methano-1H-indenediyl)bis(methylene) diacrylate | 255-901-3 | 42594-17-2 |
Reproductive toxicity (pre-natal developmental toxicity) Bioaccumulation test (Bioconcentration: Flow-through Fish Test) |
23/03/2020 23/03/2020 |
07/05/2020 07/05/2020 |
Details | |
| 4-(1,1-dimethylethyl)cyclohexyl acrylate | 282-104-8 | 84100-23-2 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
23/03/2020 23/03/2020 |
07/05/2020 07/05/2020 |
Details | |
| N,N''-(4-methyl-m-phenylene)bis[N',N'-dimethylurea] | 241-523-6 | 17526-94-2 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
23/03/2020 23/03/2020 |
07/05/2020 07/05/2020 |
Details | |
| Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid | 931-291-0 | - |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
23/03/2020 23/03/2020 |
07/05/2020 07/05/2020 |
Details | |
| (Z)-4-[C11-13 (branched) alkylamino]-4-oxo-2-butenoic acid | 701-116-0 | - | Reproductive toxicity (pre-natal developmental toxicity) | 23/03/2020 | 07/05/2020 | Details | |
| 1,4-bis(2,3-epoxypropoxy)butane | 219-371-7 | 2425-79-8 | Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with Reaction products of hexane-1,6-diol with 2-(chloromethyl)oxirane (1:2) (EC 618-939-5) | 23/03/2020 | 07/05/2020 |
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Details |
| 2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate | 224-116-8 | 4203-89-8 | Genetic toxicity in vivo | 23/03/2020 | 07/05/2020 | Details | |
| 2-[[(butylamino)carbonyl]oxy]ethyl acrylate | 264-036-0 | 63225-53-6 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 23/03/2020 | 07/05/2020 | Details | |
| 2-isocyanatoethyl methacrylate | 250-284-7 | 30674-80-7 | Reproductive toxicity (pre-natal developmental toxicity) | 23/03/2020 | 07/05/2020 | Details | |
| 4-phenylbutenone | 204-555-1 | 122-57-6 | Genetic toxicity in vivo | 23/03/2020 | 07/05/2020 | Details | |
| Dialkyl-methyl-dihydro-heteropolycyle | 815-131-6 | 913171-06-9 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 23/03/2020 | 07/05/2020 | Details | |
| Dimethyl (p-methoxybenzylidene)malonate | 231-185-8 | 7443-25-6 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 23/03/2020 | 07/05/2020 | Details | |
| Dioctyltin dilaurate | 222-883-3 | 3648-18-8 | Reproductive toxicity (pre-natal developmental toxicity) | 23/03/2020 | 07/05/2020 | Details | |
| Reaction products of 2-hydroxyethyl methacrylate and diphosphorus pentaoxide | 810-703-1 | 1187441-10-6 | Genetic toxicity in vivo | 23/03/2020 | 07/05/2020 | Details | |
| tert-butyl perbenzoate | 210-382-2 | 614-45-9 | Long-term toxicity to fish | 23/03/2020 | 07/05/2020 | Details | |
| (1S)-1,5-anhydro-2,3,4,6-tetrakis-O-(2,2-dimethylpropanoyl)-1-(3-{[5-(4-fluorophenyl)-2-thienyl]methyl}-4-methylphenyl)-D-glucitol | 695-878-0 | 1283129-18-9 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| 2,3,4,6-tetrakis-O-(2,2-dimethylpropanoyl)-α-D-glucopyranosyl bromide | 686-241-8 | 81058-27-7 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| Dibutyl itaconate | 218-451-9 | 2155-60-4 |
Sub-chronic toxicity (90-day): oral Genetic toxicity in vivo |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| Etocrilene | 226-029-0 | 5232-99-5 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| Fluorobenzene | 207-321-7 | 462-06-6 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| N,N,2,8-tetramethyl-5,11-dioxa-2,8-diazatridecan-13-amine | 695-748-3 | 65286-55-7 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| N-{2-[(phenylcarbamoyl)amino]phenyl}benzenesulfonamide | 806-543-7 | 215917-77-4 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| reaction products of benzaldehyde diethylenetriamine and triethylenetetramine, hydrogenated | 846-447-2 | 1219458-07-7 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
24/02/2020 24/02/2020 |
09/04/2020 09/04/2020 |
Details | |
| 1,1'-(ethane-1,2-diyl)bis[pentabromobenzene] | 284-366-9 | 84852-53-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 24/02/2020 | 09/04/2020 | Details | |
| 1,4-phenylenebis[(4-phenoxyphenyl)methanone] | 620-097-9 | 54299-17-1 | Bioaccumulation test in Fish, Reproductive toxicity (pre-natal developmental toxicity) | 24/02/2020 | 09/04/2020 | Details | |
| 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate | 261-665-2 | 59219-71-5 | Sub-chronic toxicity (90-day): oral | 24/02/2020 | 09/04/2020 | Details | |
| 4-tert-butylcyclohexyl acetate | 250-954-9 | 32210-23-4 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with cis-4-tert-butylcyclohexyl acetate |
24/02/2020 | 09/04/2020 | Details | |
| Camphene | 201-234-8 | 79-92-5 | Sub-chronic toxicity (90-day): oral | 24/02/2020 | 09/04/2020 | Details | |
| 2-ethylhexyl 10-ethyl-4,4-dimethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate | 260-829-0 | 57583-35-4 |
Sub-chronic toxicity (90-day): oral Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 12/03/2020 |
Details | |
| Poly(oxy-1,2-ethanediyl), α-butyl-ω-hydroxy- | 500-012-0 | 9004-77-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with 2-(2-(2-methoxyethoxy)ethoxy)ethanol (EC 203-962-1). Reproductive toxicity (pre-natal developmental toxicity) – rats-
|| Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) Reproductive toxicity (pre-natal developmental toxicity) – rabbits
|| Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) |
27/01/2020 27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 12/03/2020 |
Details | |
| Reaction products of monoethanolamine and boric acid (1:1) | 701-025-6 | - |
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0) Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Reaction products of monoethanolamine and boric acid (1:3) (EC 701-024-0) |
27/01/2020 27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 12/03/2020 |
Details | |
| Reaction products of monoethanolamine and boric acid (1:3) | 701-024-0 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 12/03/2020 |
Details | |
| 1,1'-[[3-(dimethylamino)propyl]imino]bispropan-2-ol | 264-261-4 | 63469-23-8 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| 2,2'-isopropylidenebis(p-phenyleneoxy)diethanol | 212-985-6 | 901-44-0 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| 3-[[3-[[(2-cyanoethyl)amino]methyl]-3,5,5-trimethylcyclohexyl]amino]propiononitrile | 300-496-1 | 93940-97-7 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| Diethyl ethylphosphonate | 201-111-9 | 78-38-6 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| N,N'-diphenyl-p-phenylenediamine | 200-806-4 | 74-31-7 |
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: Testing proposal is based on concern identified by the registrant. |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| Reaction products of orthoboric acid with 2,2'-iminodiethanol (1:1) | 701-083-2 | - |
Sub-chronic toxicity (90-day): oral “||Note: testing proposed with MEA Polyborate (EC 701-025-6)” "Reproductive toxicity (pre-natal developmental toxicity)
“||Note: testing proposed with MEA Polyborate (EC 701-025-6)” |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| Sodium salts of [hexane-1,6-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid (4-7 Na:1) | 947-369-2 | - |
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Potassium salts of {hexane-1,6-iylbis[nitrilobis(methylene)]}tetrakisphosphonic acid (4-7:1); EC 701-184-1
|| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Potassium salts of {hexane-1,6-iylbis[nitrilobis(methylene)]}tetrakisphosphonic acid (4-7:1); EC 701-184-1
|| Note: Testing proposal is based on concern identified by the registrant. |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| tetrahydro-2-methylfuran | 202-507-4 | 96-47-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
27/01/2020 27/01/2020 |
12/03/2020 12/03/2020 |
Details | |
| 1-imino-1H-isoindol-3-amine | 222-426-8 | 3468-11-9 | Genetic toxicity in vivo | 27/01/2020 | 12/03/2020 | Details | |
| 2-(2-(2-butoxyethoxy)ethoxy)ethanol | 205-592-6 | 143-22-6 | Reproductive toxicity (pre-natal developmental toxicity): 1st PNDT on the registered substance 2nd PNDT with the registered substance // Note: Testing proposal for an EOGRTS proposed to be conducted with the analogue substance 2-(2-(2-methoxyethoxy)ethoxy)ethanol (EC 203-962-1, CAS 112-35-6) | 27/01/2020 | 12/03/2020 | Details | |
| 4,4'-[(isopropylidene)bis(p-phenyleneoxy)]diphthalic dianhydride | 253-781-7 | 38103-06-9 | Sub-chronic toxicity (90-day): oral | 27/01/2020 | 12/03/2020 | Details | |
| 4,4'-methylenebis[N-sec-butylaniline] | 226-122-6 | 5285-60-9 | Bioaccumulation aquatic / sediment | 27/01/2020 | 12/03/2020 | Details | |
| 4-chloroformylphthalic anhydride | 214-874-8 | 1204-28-0 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 27/01/2020 | 12/03/2020 | Details | |
| Diethyl bis(2-hydroxyethyl)aminomethylphosphonate | 220-482-8 | 2781-11-5 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 27/01/2020 | 12/03/2020 | Details | |
| Ethylenediamine, salt with phosphoric acid | 238-914-9 | 14852-17-6 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 27/01/2020 | 12/03/2020 | Details | |
| m-phenylene di(acetate) | 203-596-2 | 108-58-7 | Genetic toxicity in vivo | 27/01/2020 | 12/03/2020 | Details | |
| N,N,N',N'-tetrakis(2,3-epoxypropyl)-m-xylene-α,α'-diamine | 264-438-6 | 63738-22-7 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 27/01/2020 | 12/03/2020 | Details | |
| Reaction mass of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and 3,6,9,12-tetraoxahexadecan-1-ol | 907-996-4 | - | Reproductive toxicity (pre-natal developmental toxicity) 1st and 2nd PNDTs: || Note: testing proposed with 2-92-92-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) | 27/01/2020 | 12/03/2020 | Details | |
| Tetramethylammonium hydroxide | 200-882-9 | 75-59-2 | Sub-chronic toxicity (90-day): oral // Note: testing proposed with Tetramethylammonium chloride (EC 200-880-8) || Note: Link to justification in the registration dossier not given as the information is confidential | 27/01/2020 | 12/03/2020 | Details | |
| Reaction mass of dipotassium 2-(3,4-dimethyl-1H-pyrazol-1-yl) succinate and dipotassium 2-(4,5-dimethy-1H-pyrazol-1-yl) succinate | 950-225-1 | - |
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Reaction mass of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid (EC number 940-877-5, CAS number 2241455-89-8) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Reaction mass of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid (EC number 940-877-5, CAS number 2241455-89-8) |
17/12/2019 17/12/2019 |
31/01/2020 31/01/2020 |
Details | |
| 3-[(3-{[(3-acetoxy-2,2-dimethylpropylidene)amino]methyl}-3,5,5-trimethylcyclohexyl)imino]-2,2-dimethylpropyl acetate | 805-722-7 | 1064082-81-0 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 17/12/2019 | 31/01/2020 | Details | |
| isliFe | - | - | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 17/12/2019 | 31/01/2020 | Details | |
| Sodium hydrogen N-(1-oxotetradecyl)-L-glutamate | 253-981-4 | 38517-37-2 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with L-Glutamic acid, N-coco acyl derivs., disodium salts (CAS number: 68187-30-4; EC number: 269-085-1) || Note: Testing proposal is based on concern identified by the registrant. | 17/12/2019 | 31/01/2020 | Details | |
| 2,2'-(octylimino)bisethanol | 239-555-0 | 15520-05-5 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
25/11/2019 25/11/2019 |
09/01/2020 09/01/2020 |
Details | |
| 2,4,7,9-Tetramethyldec-5-yne-4,7-diol, ethoxylated | 500-022-5 | 9014-85-1 |
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with 2,4,7,9-Tetramethyl-5-decyne-4,7-diol (CAS number 126-86-3) || |
25/11/2019 | 09/01/2020 | Details | |
| 2-hydroxy-3-propyl-2H-furan-5-one | 821-451-7 | 78920-10-2 |
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant. || |
25/11/2019 | 09/01/2020 | Details | |
| Heptanal | 203-898-4 | 111-71-7 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Heptanoic acid (CAS No. 111-14-8) |
25/11/2019 | 09/01/2020 | Details | |
| Hexaboron dizinc undecaoxide | 235-804-2 | 12767-90-7 |
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant. |
25/11/2019 | 09/01/2020 | Details | |
| Reaction mass of ethoxylated (= 3 moles) bisphenol A dimethacrylate and (1-methylethylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl) bismethacrylate | 939-702-5 | - | Long-term toxicity to fish | 25/11/2019 | 09/01/2020 | Details | |
| 2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with Propylene oxide and n-butyl glycidyl ether | 926-564-6 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
21/10/2019 21/10/2019 |
05/12/2019 05/12/2019 |
Details | |
| 2,2-bis[[(1-oxopentyl)oxy]methyl]propane-1,3-diyl divalerate | 239-937-7 | 15834-04-5 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 21/10/2019 | 05/12/2019 | Details | |
| 2-(2-(2-methoxyethoxy)ethoxy)ethanol | 203-962-1 | 112-35-6 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 21/10/2019 | 05/12/2019 | Details | |
| 2-(2-methoxyethoxy)ethanol | 203-906-6 | 111-77-3 | Reproductive toxicity (pre-natal developmental toxicity) | 21/10/2019 | 05/12/2019 | Details | |
| N,N-bis(2-ethylhexyl)-5-methyl-1H-benzotriazole-1-methylamine, N,N-bis(2-ethylhexyl)-4-methyl-1H-benzotriazole-1-methylamine, 2H-Benzotriazole-2-methanamine, N,N-bis(2-ethylhexyl)-4-methyl-, 2H-Benzotriazole-2-methanamine, N,N-bis(2-ethylhexyl)-5-methyl-, 1H-Benzotriazole-1-methanamine, N,N-bis(2-ethylhexyl)-6-methyl-(Mixture) | 939-700-4 | - | Sub-chronic toxicity (90-day): oral | 21/10/2019 | 05/12/2019 |
|
Details |
| Reaction mass of 2,2'-{methylenebis[(2,6-dimethyl-4,1-phenylene)oxymethylene]}dioxirane and 1,3-bis{4-[3,5-dimethyl-4-(oxiran-2-ylmethoxy)benzyl]-2,6-dimethylphenoxy}propan-2-ol and 3,3'-{methylenebis[(2,6-dimethyl-4,1-phenylene)oxy]}bis(1-{4-[3,5-dimethyl-4-(oxiran-2-ylmethoxy)benzyl]-2,6-dimethylphenoxy}propan-2-ol) | 941-357-0 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) | 21/10/2019 | 05/12/2019 | Details | |
| 2,4,7,9-tetramethyl-4,7-decanediol | 451-160-7 | 17913-76-7 |
Long-term toxicity to fish "|| Note: testing proposed with 2,4,7,9-tetramethyldec-5-yne-4,7-diol (EC 204-809-1, CAS 126-86-3) Reproductive toxicity (pre-natal developmental toxicity) |
17/09/2019 17/09/2019 |
01/11/2019 01/11/2019 |
Details | |
| Fatty acids, C18-unsatd., dimers, oligomeric reaction products with triethylenetetramine | 500-290-3 | 103758-99-2 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (CAS 68082-29-1; EC 500-191-5) Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (CAS 68082-29-1; EC 500-191-5) |
17/09/2019 17/09/2019 |
01/11/2019 01/11/2019 |
Details | |
| tetrasodium 7-[(E)-2-[2-(carbamoylamino)-4-{[4-chloro-6-({4-[2-(sulfooxy)ethanesulfonyl]phenyl}amino)-1,3,5-triazin-2-yl]amino}phenyl]diazen-1-yl]naphthalene-1,3,6-trisulfonate | 474-870-9 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
17/09/2019 17/09/2019 |
01/11/2019 01/11/2019 |
Details | |
| 1-aminopropan-2-ol | 201-162-7 | 78-96-6 | Reproductive toxicity (pre-natal developmental toxicity) | 17/09/2019 | 01/11/2019 | Details | |
| 2,2'-(cyclohexylimino)bisethanol | 224-809-5 | 4500-29-2 | Reproductive toxicity (pre-natal developmental toxicity) | 17/09/2019 | 01/11/2019 | Details | |
| Butanoic acid, 4-amino-4-oxo-2(or 3)-sulfo-,N-(C16-C18 (even numbered), C18 unsaturated alkyl)), disodium salts | 939-691-7 | - | Reproductive toxicity (pre-natal developmental toxicity) | 17/09/2019 | 01/11/2019 | Details | |
| Hydroxycyclohexyl phenyl ketone | 213-426-9 | 947-19-3 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 17/09/2019 | 01/11/2019 | Details | |
| Benzene, diethenyl- and Benzene, ethenylethyl- | 910-757-7 | - |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
16/08/2019 16/08/2019 |
30/09/2019 30/09/2019 |
Details | |
| N,N'-dimethyldiphenylthiuram disulphide | 234-196-6 | 10591-84-1 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
16/08/2019 16/08/2019 |
30/09/2019 30/09/2019 |
|
Details |
| Reaction mass of 1,3-Propanediol, 2-(hydroxymethyl)-2-[(methoxymethoxy)methyl]- and 1,3-dioxane-5,5-dimethanol | 911-819-6 | - |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
16/08/2019 16/08/2019 |
30/09/2019 30/09/2019 |
Details | |
| Sodium diisobutyldithiophosphinate | 236-419-2 | 13360-78-6 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) with Rat |
24/07/2019 24/07/2019 |
09/09/2019 09/09/2019 |
Details | |
| 1,3,5-tris[[4-tert-butyl-3-hydroxy-2,6-xylyl]methyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione | 254-996-9 | 40601-76-1 | Reproductive toxicity (pre-natal developmental toxicity) with Rat | 24/07/2019 | 09/09/2019 | Details | |
| 4-fluoro-1,3-dioxolan-2-one | 483-360-5 | 114435-02-8 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 24/07/2019 | 09/09/2019 | Details | |
| Bis(2-chloroethyl) 3,3'-[(2,5-dimethyl-p-phenylene)bis[iminocarbonyl(2-hydroxy-1,3-naphthylene)azo]]di-p-toluate | 269-507-4 | 68259-05-2 | Sub-chronic toxicity (90 day): inhalation || Note: Testing proposal is based on concern identified by the registrant | 24/07/2019 | 09/09/2019 | Details | |
| Heptanoic acid | 203-838-7 | 111-14-8 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 24/07/2019 | 09/09/2019 | Details | |
| Reaction mass of trans-Cyclohexadecen-8-one, cis-Cyclohexadecen-8-one, trans-Cyclohexadecen-7-one, cis-Cyclohexadecen-7-one | 448-300-4 | 88642-03-9 | Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant. | 24/07/2019 | 09/09/2019 | Details | |
| Sodium dihydrogenorthophosphate | 231-449-2 | 7558-80-7 | Sub-chronic toxicity (90-day): oral | 24/07/2019 | 09/09/2019 | Details | |
| Sophorolipids: fermentation products of glucose and fatty acids, C18 (unsaturated), glycerol esters with yeast Candida Bombicola, partially hydrolysed | 941-809-7 | - | Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant. | 24/07/2019 | 09/09/2019 | Details | |
| Fatty acids, C12-14, α-sulfo, disodium salts | 942-523-5 | - |
Long-term toxicity to fish (OECD 212 – Registrant’s preference) Sub-chronic toxicity (90-day): oral on rodents Reproductive toxicity (pre-natal developmental toxicity) on rodents |
25/06/2019 25/06/2019 25/06/2019 |
09/08/2019 09/08/2019 09/08/2019 |
Details | |
| Asphalt | 232-490-9 | 8052-42-4 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
[note whilst the registrant has selected the drop down of a RaX TPE – it is not a RaX TPE – registered substance is being tested]” |
25/06/2019 | 09/08/2019 | Details | |
| Asphalt, oxidized | 265-196-4 | 64742-93-4 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/06/2019 | 09/08/2019 | Details | |
| Benzyltoluene | 248-654-8 | 27776-01-8 | Long-term toxicity to fish (OECD 210) | 25/06/2019 | 09/08/2019 | Details | |
| Di-tert-butyl 3,3,5-trimethylcyclohexylidene diperoxide | 229-782-3 | 6731-36-8 | Bioaccumulation aquatic / sediment | 25/06/2019 | 09/08/2019 | Details | |
| Ethanol, 2,2'-iminobis-, N-C12-18-alkyl derivs. | 276-014-8 | 71786-60-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/06/2019 | 09/08/2019 |
|
Details |
| Hexamethyldisiloxane | 203-492-7 | 107-46-0 | Reproductive toxicity (pre-natal developmental toxicity) with the rabbit via inhalation | 25/06/2019 | 09/08/2019 | Details | |
| pentasodium 5-{[4-chloro-6-({4-[2-(sulfooxy)ethanesulfonyl]phenyl}amino)-1,3,5-triazin-2-yl]amino}-3-[2-(1,5-disulfonaphthalen-2-yl)diazen-1-yl]-4-hydroxynaphthalene-2,7-disulfonate | 402-420-3 | 89157-03-9 | Sub-chronic toxicity (90-day): oral | 25/06/2019 | 09/08/2019 | Details | |
| Residues (petroleum), thermal cracked vacuum | 295-518-9 | 062-05-0 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Asphalt (CAS 8052-42-4) | 25/06/2019 | 09/08/2019 | Details | |
| Residues (petroleum), vacuum | 265-057-8 | 64741-56-6 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/06/2019 | 09/08/2019 | Details | |
| Strontium oxide | 215-219-9 | 1314-11-0 | Reproductive toxicity (pre-natal developmental toxicity) | 25/06/2019 | 09/08/2019 | Details | |
| Triisotridecyl phosphite | 278-758-9 | 77745-66-5 | Sub-chronic toxicity (90-day): oral | 25/06/2019 | 09/08/2019 | Details | |
| Reaction mass of Octadecanamide, 12-hydroxy-N-[2-[(1-oxodecyl)amino]ethyl]- and N,N'-ethane-1,2-diylbis(12-hydroxyoctadecan-1-amide) and Decanamide, N,N'-1,2-ethanediylbis- | 907-495-0 | - |
Reproductive toxicity (pre-natal developmental toxicity): in rat and rabbit Sub-chronic toxicity (90 day): inhalation Reproductive toxicity (extended one-generation reproductive toxicity study) |
27/05/2019 27/05/2019 27/05/2019 |
11/07/2019 11/07/2019 11/07/2019 |
Details | |
| Benzene, 1,1'-oxybis-, tetrapropylene derivatives, sulfonated, sodium salts | 601-601-6 | 119345-04-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) with the Rabbit |
27/05/2019 27/05/2019 |
11/07/2019 11/07/2019 |
Details | |
| Lithium bis(oxalato)borate | 456-990-3 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
27/05/2019 27/05/2019 |
11/07/2019 11/07/2019 |
Details | |
| Methylphosphonic acid | 213-607-2 | 993-13-5 |
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Methylphosphonic acid, compound with amidinourea (1:1) (EC 282-758-4) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Methylphosphonic acid, compound with amidinourea (1:1) (EC 282-758-4) |
27/05/2019 27/05/2019 |
11/07/2019 11/07/2019 |
Details | |
| tri{[(2s)-1-ethoxy-1-oxopropan-2-yl]oxy}(vinyl)silane | 701-301-6 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
27/05/2019 27/05/2019 |
11/07/2019 11/07/2019 |
Details | |
| [1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide | 246-678-3 | 25155-25-3 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 27/05/2019 | 11/07/2019 | Details | |
| Alcohols, C11-14-iso-, C13-rich | 271-235-6 | 68526-86-3 | Reproductive toxicity (pre-natal developmental toxicity) | 27/05/2019 | 11/07/2019 | Details | |
| Butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate | 401-100-0 | - | Sub-chronic toxicity (90-day): oral | 27/05/2019 | 11/07/2019 |
|
Details |
| Furan-2,5-dicarboxylic acid | 221-800-8 | 3238-40-2 | Reproductive toxicity (pre-natal developmental toxicity) | 27/05/2019 | 11/07/2019 | Details | |
| Hexanal | 200-624-5 | 66-25-1 | Genetic toxicity in vivo “|| Note: Testing proposal is based on concern identified by the registrant.” | 27/05/2019 | 11/07/2019 | Details | |
| Reaction mass of 2,2'-[(4-methylphenyl)imino]bisethanol and Ethanol 2-[[2-(2-hydroxyethoxy)ethyl](4-methylphenyl)amino]- | 911-490-9 | - | Sub-chronic toxicity (90-day): oral | 27/05/2019 | 11/07/2019 | Details | |
| Reaction mass of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and 3,6,9,12-tetraoxahexadecan-1-ol | 907-996-4 | - | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) | 27/05/2019 | 11/07/2019 | Details | |
| Reaction Mass of Benzyl (1R,1S) 2,2,4-trimethyl-1-[(2-methylpropanoyl)oxy]pentan-3-yl benzene-1,2-dicarboxylate and Benzyl (3R,3S) 2,2,4-trimethyl-3-[(2-methylpropanoyl)oxy]pentyl benzene-1,2-dicarboxylate | 701-008-3 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) | 27/05/2019 | 11/07/2019 | Details | |
| Sodium hydroxymethanesulphinate | 205-739-4 | 149-44-0 | Reproductive toxicity (pre-natal developmental toxicity) | 27/05/2019 | 11/07/2019 | Details | |
| Isobutyric acid, monoester with 2,2,4-trimethylpentane-1,3-diol | 246-771-9 | 25265-77-4 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
26/04/2019 26/04/2019 26/04/2019 |
10/06/2019 10/06/2019 10/06/2019 |
Details | |
| Zinc, O,O-mixed (iso-Bu), (iso-Pr), (pentyl) phosphorodithioate | 820-225-5 | 101747-77-7 |
Sub-chronic toxicity (90-day): oral “|| Note: testing proposed with [Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts] (EC 270-608-0) Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with [Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts] (EC 270-608-0) Reproductive toxicity (pre-natal developmental toxicity) “|| Note: testing proposed with [Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts] (EC 270-608-0) |
26/04/2019 26/04/2019 26/04/2019 |
10/06/2019 10/06/2019 10/06/2019 |
Details | |
| 3-(trimethoxysilyl)propylamine | 237-511-5 | 13822-56-5 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
26/04/2019 26/04/2019 |
10/06/2019 10/06/2019 |
Details | |
| Biphenyl-4,4'-diol | 202-200-5 | 92-88-6 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
26/04/2019 26/04/2019 |
10/06/2019 10/06/2019 |
Details | |
| Ethylenediamine, propoxylated | 500-035-6 | 25214-63-5 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
26/04/2019 26/04/2019 |
10/06/2019 10/06/2019 |
Details | |
| 2-Propyn-1-ol, reaction product with 1-2.5 moles of oxirane | 941-793-1 | - | Reproductive toxicity (pre-natal developmental toxicity) | 26/04/2019 | 10/06/2019 | Details | |
| 3-trimethoxysilylpropyl methacrylate | 219-785-8 | 2530-85-0 | Reproductive toxicity (pre-natal developmental toxicity) | 26/04/2019 | 10/06/2019 | Details | |
| Propylidynetrimethyl trimethacrylate | 221-950-4 | 3290-92-4 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 26/04/2019 | 10/06/2019 | Details | |
| Strontium neodecanoate | 812-724-1 | 106705-37-7 | Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with [Strontium oxide] (EC 215-219-9) | 26/04/2019 | 10/06/2019 | Details | |
| Perfluamine | 206-420-2 | 338-83-0 |
Genetic toxicity in vivo (Mammalian Erythrocyte Micronucleus Test) Genetic toxicity in vivo (In vivo Mammalian Alkaline Comet Assay) Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
29/03/2019 29/03/2019 29/03/2019 29/03/2019 |
13/05/2019 13/05/2019 13/05/2019 13/05/2019 |
Details | |
| Reaction mass of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid | 940-877-5 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
29/03/2019 29/03/2019 |
13/05/2019 13/05/2019 |
Details | |
| Distillates (petroleum), hydrodesulfurized middle | 265-183-3 | 64742-80-9 |
Sub-chronic toxicity (90 day): dermal Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
28/02/2019 28/02/2019 28/02/2019 |
15/04/2019 15/04/2019 15/04/2019 |
Details | |
| Distillates (petroleum), hydrotreated middle | 265-148-2 | 64742-46-7 |
Sub-chronic toxicity (90 day): dermal Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
28/02/2019 28/02/2019 28/02/2019 |
15/04/2019 15/04/2019 15/04/2019 |
Details | |
| Extracts (petroleum), deasphalted vacuum residue solvent | 295-332-8 | 91995-70-9 |
Sub-chronic toxicity (90 day): dermal Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
28/02/2019 28/02/2019 28/02/2019 |
15/04/2019 15/04/2019 15/04/2019 |
Details | |
| Extracts (petroleum), residual oil solvent | 265-110-5 | 64742-10-5 |
Sub-chronic toxicity (90 day): dermal Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
28/02/2019 28/02/2019 28/02/2019 |
15/04/2019 15/04/2019 15/04/2019 |
Details | |
| Gas oils (petroleum), hydrodesulfurized | 265-182-8 | 64742-79-6 |
Sub-chronic toxicity (90 day): dermal Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
28/02/2019 28/02/2019 28/02/2019 |
15/04/2019 15/04/2019 15/04/2019 |
Details | |
| 3a,4,7,7a-tetrahydro-4,7-methanoindene | 201-052-9 | 77-73-6 | Reproductive toxicity (pre-natal developmental toxicity) | 28/02/2019 | 15/04/2019 | Details | |
| Hydrocarbons, C16-C18, isoalkanes,<2% aromatics | 948-766-3 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) | 28/02/2019 | 15/04/2019 | Details | |
| Nickel | 231-111-4 | 7440-02-0 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 28/02/2019 | 15/04/2019 | Details | |
| Reaction products of acrylic acid with 2,2'-[oxybis(methylene)]bis[2-ethylpropane-1,3-diol] | 830-217-3 | 1393932-71-2 |
Sub-chronic toxicity (90-day): oral || Note: Link to registration dossier not given as the dossier not yet disseminated Reproductive toxicity (pre-natal developmental toxicity) || Note: Link to registration dossier not given as the dossier not yet disseminated |
24/01/2019 24/01/2019 |
11/03/2019 11/03/2019 |
Details | |
| 1,3,2-dioxathiolane 2,2-dioxide | 600-809-4 | 1072-53-3 | Genetic toxicity in vivo || Note: Link to registration dossier not given as the dossier not yet disseminated || Note: Testing proposal is based on concern identified by the registrant. | 24/01/2019 | 11/03/2019 | Details | |
| N-(3-aminopropyl)-N'-C16-18 (evennumbered), C18 unsaturated alkyl -propane-1,3-diamine | 628-863-4 | 1219458-14-6 | Reproductive toxicity (pre-natal developmental toxicity) | 24/01/2019 | 11/03/2019 | Details | |
| Reaction mass of N,N,N',N'-tetrabutylmethylenediamine and dibutylamine | 948-040-6 | - | Genetic toxicity in vivo || Note: Link to registration dossier not given as the dossier not yet disseminated. || Note: Testing proposal is based on concern identified by the registrant. | 24/01/2019 | 11/03/2019 | Details | |
| benzyl butyl cis-cyclohexane-1,2-dicarboxylate | 701-279-8 | 1931129-39-3 |
Long-term toxicity to fish || Note: Link to the registration dossier not given as the dossier not yet disseminated. || Note: this substance was previously registered, identified and disseminated with EC No. 810-685-5 Sub-chronic toxicity (90-day): oral || Note: Link to registration dossier not given as the dossier not yet disseminated. || Note: this substance was previously registered, identified and disseminated with EC No. 810-685-5 Reproductive toxicity (pre-natal developmental toxicity) || Note: Link to registration dossier not given as the dossier not yet disseminated. || Note: this substance was previously registered, identified and disseminated with EC No. 810-685-5 |
10/12/2018 10/12/2018 10/12/2018 |
24/01/2019 24/01/2019 24/01/2019 |
Details | |
| hexamolybdenum(3+) tris((dioctylcarbamothioyl)sulfanide) tris((ditridecylcarbamothioyl)sulfanide) hexahydrate hexasulfanediide | 441-570-4 | - |
Bioaccumulation aquatic / sediment || Note: Link to registration dossier not given as the dossier not yet disseminated. Sub-chronic toxicity (90-day): oral || Note: Link to registration dossier not given as the dossier not yet disseminated. Reproductive toxicity (pre-natal developmental toxicity) || Note: Link to registration dossier not given as the dossier not yet disseminated. |
10/12/2018 10/12/2018 10/12/2018 |
24/01/2019 24/01/2019 24/01/2019 |
Details | |
| 1,4-Cyclohexanedicarboxylic acid, 1,4-diisononyl ester | 701-012-5 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
10/12/2018 10/12/2018 |
24/01/2019 24/01/2019 |
Details | |
| 4-oxovaleric acid | 204-649-2 | 123-76-2 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
10/12/2018 10/12/2018 |
24/01/2019 24/01/2019 |
Details | |
| Propionaldehyde, reaction product with formaldehyde | 701-281-9 | - | Genetic toxicity in vivo || Note: the EC/list number of the substance has been changed. | 10/12/2018 | 24/01/2019 | Details | |
| Fatty acids, C12-14, α-sulfo, disodium salts | 942-523-5 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
02/11/2018 02/11/2018 |
17/12/2018 17/12/2018 |
Details | |
| 1-Dodecene, dimers | 814-509-8 | 62132-67-6 | Reproductive toxicity (pre-natal developmental toxicity) | 02/11/2018 | 17/12/2018 | Details | |
| 2,2,4,4,6,8,8-heptamethylnonane | 224-506-8 | 4390-04-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with two substances in a grouping approach: Icosane (EC 204-015-1) and Hydrocarbons, C14-C19, iso-alkanes, cyclics; aromatics <2% (920-114-2) | 02/11/2018 | 17/12/2018 | Details | |
| Alkane-alpha,omega-diyl bis{[(trimethoxysilyl)propyl]carbamate}_M2 | 700-904-1 | 1350725-68-6 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Methyl [3-(trimethoxysilyl) propyl]carbamate CAS 23432-62-4 | 02/11/2018 | 17/12/2018 | Details | |
| Alkenes, C13-14, hydroformylation products, distn. residues | 292-429-7 | 90622-29-0 | Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with Alkenes, C11-12, hydroformylation products, distn. residues (EC 292-427-6) | 02/11/2018 | 17/12/2018 | Details | |
| Alkenes, C7-9, hydroformylation products, distn. residues, heavy cracked fraction | 308-482-7 | 98072-31-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 02/11/2018 | 17/12/2018 | Details | |
| Diethyl ether | 200-467-2 | 60-29-7 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 02/11/2018 | 17/12/2018 | Details | |
| Hydrocarbons, C14-C16, n-alkanes, <2% aromatics | 921-535-4 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) | 02/11/2018 | 17/12/2018 | Details | |
| Hydrocarbons, C14-C17, n-alkanes, <2% aromatics | 917-828-1 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with two substances in a group: Icosane (EC 204-018-1) and Hydrocarbons, C14-C19, isoalkanes, cyclics, < 2% aromatics (920-114-2) | 02/11/2018 | 17/12/2018 | Details | |
| Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts | 283-392-8 | 84605-29-8 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
| Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and iso-Pr) esters, zinc salts | 288-917-4 | 85940-28-9 |
"Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) ""Testing proposed according to a plan for the ZDDP category.“
" Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
| Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu) esters, zinc salts | 270-478-5 | 68442-22-8 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
| Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts | 272-723-1 | 68909-93-3 |
Sub-chronic toxicity (90-day): oral || Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
| Phosphorodithioic acid, mixed O,O-bis(sec-Bu and 1,3-dimethylbutyl) esters, zinc salts | 272-238-5 | 68784-31-6 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
| Zinc bis(O,O-diisooctyl) bis(dithiophosphate) | 249-109-7 | 28629-66-5 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
| Zinc bis[bis(tetrapropylenephenyl)] bis(hydrogen dithiophosphate) | 234-277-6 | 11059-65-7 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
| zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) | 224-235-5 | 4259-15-8 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
| Zinc bis[O-(6-methylheptyl)] bis[O-(sec-butyl)] bis(dithiophosphate) | 298-577-9 | 93819-94-4 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
| Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) | 230-257-6 | 6990-43-8 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
| Zinc O,O,O',O'-tetrakis(1,3-dimethylbutyl) bis(phosphorodithioate) | 218-679-9 | 2215-35-2 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category. |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
| Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and pentyl) esters, zinc salts | 273-527-9 | 68988-45-4 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" |
04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 |
Details | |
| Tall oil, maleated | 268-859-6 | 68152-93-2 |
Bioaccumulation aquatic / sediment Long-term toxicity to fish |
04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 |
Details | |
| Zinc bis[bis(dodecylphenyl)] bis(dithiophosphate) | 259-048-8 | 54261-67-5 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 |
|
Details |
| Zinc bis[O-(2-ethylhexyl)] bis[O-(isobutyl)] bis(dithiophosphate) | 247-810-2 | 26566-95-0 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category" |
04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 |
Details | |
| Dihydrogen hexahydroxyplatinate, compound with 2-aminoethanol (1:2) | 268-717-3 | 68133-90-4 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 04/10/2018 | 19/11/2018 | Details | |
| N-[(3-methyl-1H-pyrazol-1-yl)methyl]acetamide; N-[(5-methyl-1H-pyrazol-1-yl)methyl]acetamide | 700-208-8 | - | Sub-chronic toxicity (90-day): oral | 04/10/2018 | 19/11/2018 | Details | |
| C14-16 (even numbered) and C16 (branched) saturated and unsaturated aliphatic hydrocarbons | 700-762-0 | - |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with an analogue substance. Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with an analogue substance. Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with an analogue substance. |
01/10/2018 01/10/2018 01/10/2018 |
15/11/2018 15/11/2018 15/11/2018 |
Details | |
| Pleuromulin | 204-747-5 | 125-65-5 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
06/09/2018 06/09/2018 06/09/2018 |
22/10/2018 22/10/2018 22/10/2018 |
Details | |
| Reaction mass of 2-ethyl-2-(methoxymethyl)-propane-1,3-diol and 2-ethylpropane-1,3-diol | 938-572-7 | - |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
06/09/2018 06/09/2018 |
22/10/2018 22/10/2018 |
Details | |
| 2-(2-thienyl)ethyl toluene-p-sulphonate | 254-911-5 | 40412-06-4 | Genetic toxicity in vivo | 06/09/2018 | 22/10/2018 | Details | |
| 4,4'-isopropylidenedicyclohexanol | 201-244-2 | 80-04-6 | Reproductive toxicity (pre-natal developmental toxicity) | 06/09/2018 | 22/10/2018 | Details | |
| 5-Methoxy-2-tetralone | 457-080-9 | - | Genetic toxicity in vivo | 06/09/2018 | 22/10/2018 | Details | |
| Polysulfides, di-tert-nonyl | 270-336-2 | 68425-16-1 | Sub-chronic toxicity (90-day): oral | 06/09/2018 | 22/10/2018 | Details | |
| Soybean oil, oligomerized | 701-252-0 | - | Reproductive toxicity (pre-natal developmental toxicity) | 06/09/2018 | 22/10/2018 | Details | |
| (6R-trans)-7-amino-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 261-491-7 | 58909-56-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. |
10/08/2018 10/08/2018 10/08/2018 |
24/09/2018 24/09/2018 24/09/2018 |
Details | |
| 3-acetoxymethylen-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 213-485-0 | 957-68-6 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. |
10/08/2018 10/08/2018 10/08/2018 |
24/09/2018 24/09/2018 24/09/2018 |
Details | |