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Previous Testing Proposals

Previous Testing Proposals

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

 
[1,3-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide 218-664-7 2212-81-9
Bioaccumulation aquatic / sediment
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant
20/10/2016
20/10/2016
05/12/2016
05/12/2016
5,5'-dithiodi-1,3,4-thiadiazole-2(3H)-thione 276-763-0 72676-55-2 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 20/10/2016 05/12/2016
Bis(α,α-dimethylbenzyl) peroxide 201-279-3 80-43-3 Reproductive toxicity (pre-natal developmental toxicity 20/10/2016 05/12/2016
N-butyl-2,2,6,6-tetramethylpiperidin-4-amine 252-899-6 36177-92-1
Sub-chronic toxicity (90-day): ora
Reproductive toxicity (pre-natal developmental toxicity)
07/10/2016
07/10/2016
21/11/2016
21/11/2016
tert-pentyl hydroperoxide 222-321-7 3425-61-4
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
07/10/2016
07/10/2016
21/11/2016
21/11/2016
2-ethylhexyl 10-ethyl-4,4-dimethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate 260-829-0 57583-35-4
Sub-chronic toxicity (90-day): oral
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity
01/09/2016
01/09/2016
01/09/2016
17/10/2016
17/10/2016
17/10/2016
Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts 270-608-0 68457-79-4
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
01/09/2016
01/09/2016
01/09/2016
17/10/2016
17/10/2016
17/10/2016
4-hydroxy-4-methylpentan-2-one 204-626-7 123-42-2
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
01/09/2016
01/09/2016
17/10/2016
17/10/2016
Sodium dihydrogenorthophosphate 231-449-2 7558-80-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 01/09/2016 17/10/2016
cobalt dichloride 231-589-4 7646-79-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
18/07/2016
18/07/2016
01/09/2016
01/09/2016


1,2,4,5,7,8-Hexoxonane, 3,6,9-trimethyl-, 3,6,9-tris(Ethyl and Propyl) derivatives - - Sub-chronic toxicity (90-day): oral 30/06/2016 15/08/2016
boron orthophosphate - 13308-51-5 Reproductive toxicity (pre-natal developmental toxicity) 30/06/2016 15/08/2016
Fatty acids, tall-oil, di- and triesters with trimethylolpropane 941-376-4 -
Long-term toxicity to aquatic invertebrates
Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates.
Testing proposed with EC No 931-531-4.
31/05/2016
31/05/2016
31/05/2016
15/07/2016
15/07/2016
15/07/2016
((3-(sec-butyl)-4-(decyloxy)phenyl)methanetriyl)tribenzene 801-941-7 1404190-37-9
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
31/05/2016
31/05/2016
15/07/2016
15/07/2016
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with maleic anhydride and methacrylic acid 500-090-6 36425-16-8
Sub-chronic toxicity (90-day): oral || Note: testing proposed with a structurally related substance (small vinyl ester)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with a structurally related substance (small vinyl ester)
31/05/2016
31/05/2016
15/07/2016
15/07/2016
ASPHALT 232-490-9 8052-42-4
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
31/05/2016
31/05/2016
15/07/2016
15/07/2016
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, esters with acrylic acid 500-130-2 55818-57-0 Reproductive toxicity (pre-natal developmental toxicity) 31/05/2016 15/07/2016
ALCOHOLS, C11-14-ISO-, C13-RICH 271-235-6 68526-86-3 Sub-chronic toxicity (90-day): oral 31/05/2016 15/07/2016
ALCOHOLS, C7-9-ISO-, C8-RICH 271-231-4 68526-83-0 Sub-chronic toxicity (90-day): oral 31/05/2016 15/07/2016
Propylidynetrimethyl trimethacrylate 221-950-4 3290-92-4 Reproductive toxicity (pre-natal developmental toxicity) 31/05/2016 15/07/2016
Reaction mass of C18 (unsatd.) fatty acid amides/esters of diethanolamine, C16-18 (even-numbered) fatty amine (..) 943-172-0 -
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (extended one-generation reproductive toxicity study)
17/05/2016
17/05/2016
17/05/2016
01/07/2016
01/07/2016
01/07/2016
Melamine 203-615-4 108-78-1 Reproductive toxicity (extended one-generation reproductive toxicity study) 17/05/2016 01/07/2016
Methylene-bis-4,1-(N-phenylene-N'-butylurea) 416-600-4 - Bioaccumulation aquatic / sediment 17/05/2016 01/07/2016
1,1,3,3-tetramethyldisiloxane 221-906-4 3277-26-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): inhalation
29/04/2016
29/04/2016
13/06/2016
13/06/2016
tris[2-[2-(2-methoxyethoxy)ethoxy]ethyl] orthoborate 250-418-4 30989-05-0
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
29/04/2016
29/04/2016
13/06/2016
13/06/2016
N,N''-propane-1,3-diylbis[N'-octadecylurea 252-667-4 35674-65-8 Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) 29/03/2016 13/05/2016
1-isopropyl-2,2-dimethyltrimethylene diisobutyrate 229-934-9 6846-50-0 Reproductive toxicity (pre-natal developmental toxicity) 14/03/2016 28/04/2016
2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol 620-540-6 1218787-32-6 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 2,2'-(Octadec-9-enylimino) bisethanol, CAS No 25307-17-9 14/03/2016 28/04/2016
Shale oils 269-646-0 68308-34-9 Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with Shale oils, heavy fractions (Registration No 01-2119756217-35-0000)” Sub-chronic toxicity (90-day): oral “|| Note: testing proposed with Shale oils, heavy fractions (Registration No 01-2119756217-35-0000)” 14/03/2016 28/04/2016
Shale oils, light 923-592-0 - Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with Shale oils, heavy fraction (Registration No 01-2119756217-35-0000)||” Sub-chronic toxicity (90-day): oral “|| Note: testing proposed with Shale oils, heavy fraction (Registration No 01-2119756217-35-0000)||” 14/03/2016 28/04/2016
2,2-dimethylpropane-1,3-diyl dibenzoate 224-081-9 4196-89-8 Reproductive toxicity (pre-natal developmental toxicity) 29/02/2016 14/04/2016
Acetic acid, chloro-, sodium salt, reaction products with 4,5-dihydro-2-undecyl-1H-imidazole-1-ethanol and sodium hydroxide 271-794-6 68608-66-2 Long-term toxicity to fish Sub-chronic toxicity (90-day): oral || Note: testing proposed with Reaction products of 1H-Imidazole- 1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid (EC 931-291-0) Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid (EC 931-291-0 29/02/2016 14/04/2016
N-butylbenzenesulphonamide 222-823-6 3622-84-2 Reproductive toxicity (pre-natal developmental toxicity) 29/02/2016 14/04/2016
2,2'-dimethyl-2,2'-azodipropiononitrile 201-132-3 78-67-1 Reproductive toxicity (pre-natal developmental toxicity) 03/02/2016 21/03/2016
2-(2-Ethoxyethoxy)-2-methylpropanee 257-196-8 51422-54-9 Sub-chronic toxicity (90 day): inhalation Reproductive toxicity (pre-natal developmental toxicity) 03/02/2016 21/03/2016
Esterification products of 4,4'-isopropylidenediphenol, ethoxylated and prop-2-enoic acid. 613-584-2 64401-02-1 Genetic toxicity in vivo 03/02/2016 21/03/2016
O,O,O-triphenyl phosphorothioate 209-909-9 597-82-0 Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: Testing proposal is based on concern identified by the registrant.” 03/02/2016 21/03/2016
Reaction mass of 1-(2,3-epoxypropoxy)-2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane 608-489-8 - Genetic toxicity in vivo 03/02/2016 21/03/2016
triethoxy(3-isocyanatopropyl)silane 246-467-6 24801-88-5 Genetic toxicity in vivo

Note: testing proposed with 3-(Trimethoxysilyl)propyl isocyanate (EC 239-415-9)
03/02/2016 21/03/2016
1,4-Cyclohexanedimethanol, reaction products with epichlorohydrin 600-447-7 1035218-79-1
Reproductive toxicity (pre-natal developmental toxicity) || Note: Link to registration dossier not given as the dossier not yet disseminated
Sub-chronic toxicity (90 day): inhalation || Note: Link to registration dossier not given as the dossier not yet disseminated
23/12/2015
23/12/2015
03/02/2016
03/02/2016
Poly(oxy-1,2-ethanediyl), .alpha.-[3-[(carboxymethyl)methylamino]-2-hydroxypropyl]-.omega.-(4-nonylphenoxy)-, monosodium sal 616-248-3 75627-31-5
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity
23/12/2015
23/12/2015
03/02/2016
03/02/2016
Amines, tallow alkyl, dodecylbenzenesulfonates 268-766-0 68139-94-6
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant
Reproductive toxicity (pre-natal developmental toxicity)
30/11/2015
30/11/2015
30/11/2015
14/01/2016
14/01/2016
14/01/2016
Formaldehyde, oligomeric reaction products with phenol and m-phenylenebis(methylamine) 500-137-0 57214-10-5
Sub-chronic toxicity (90-day): oral
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
30/11/2015
30/11/2015
30/11/2015
14/01/2016
14/01/2016
14/01/2016
2,4-Pentanedione, peroxide 253-384-9 37187-22-7
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
30/11/2015
30/11/2015
14/01/2016
14/01/2016
Distilled tall oil, magnesium salts 939-629-9 -
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
30/11/2015
30/11/2015
14/01/2016
14/01/2016
Fatty acids, C18-unsatd., dimers, reaction products with polyethylenepolyamines 614-452-7 68410-23-1
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (CAS 68082-29-1)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (CAS 68082-29-1)
30/11/2015
30/11/2015
14/01/2016
14/01/2016
orthoboric acid, compound with 2,2'-iminodiethanol 267-886-0 67952-33-4
Sub-chronic toxicity (90-day): oral || Note: testing proposed with MEA Polyborate
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with MEA Polyborate
30/11/2015
30/11/2015
14/01/2016
14/01/2016
Reaction mass of (2S-cis)-tetrahydro-4-methyl-2-(2-methyl-1-propenyl)-2H-pyran and Tetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyran (2R,4R) and Tetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyran (2S,4S) and (2R-cis)-tetrahydro-4-methyl-2-(2-methyl-1-propenyl)-2H-pyran 939-429-1 16409-43-1
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
30/11/2015
30/11/2015
14/01/2016
14/01/2016
(octadecanoato-O)oxoaluminium 236-521-7 13419-15-3 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Aluminum, benzoate C16-18 fatty acid complexes (CAS 94166-87-7) 30/11/2015 14/01/2016
2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-octyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate 248-227-6 27107-89-7 Genetic toxicity in vivo 30/11/2015 14/01/2016
[1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide 246-678-3 25155-25-3 Reproductive toxicity (pre-natal developmental toxicity) 30/11/2015 14/01/2016
D-glucopyranose, oligomeric, C10-16 glycosides (even numbered), carboxymethyl ethers, sodium salts 609-542-8 383178-66-3 Reproductive toxicity (pre-natal developmental toxicity) 30/11/2015 14/01/2016
Fats and Glyceridic oils, vegetable, winterized, reaction products with ammonia-ethanolamine reaction products 800-253-4 - Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates.

Link to registration dossier not given as the dossier not yet disseminated.
30/11/2015 14/01/2016
Hydrochloric acid, reaction products with aniline and nitrobenzene, sulfonated, sodium salts 291-454-0 90411-76-0 Reproductive toxicity (pre-natal developmental toxicity) 30/11/2015 14/01/2016
N-{2-[(phenylcarbamoyl)amino]phenyl}benzenesulfonamide 806-543-7 215917-77-4 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 30/11/2015 14/01/2016
Reaction products of tryglycerides, C8-C18 (even numbered) and C18-unsaturated, glycerine and ethylene oxide 939-459-5 - Sub-chronic toxicity (90-day): oral 30/11/2015 14/01/2016
8,9,10-trinorborn-2-ene 207-866-0 498-66-8
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (extended one-generation reproductive toxicity study)
01/11/2015
01/11/2015
16/12/2015
16/12/2015
Amines, polyethylenepoly-, tetraethylenepentamine fraction 292-587-7 90640-66-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 01/11/2015 16/12/2015
N-vinylformamide 236-102-9 13162-05-5 Reproductive toxicity (extended one-generation reproductive toxicity study) 01/11/2015 16/12/2015
N,N'-ethane-1,2-diylbis(12-hydroxyoctadecan-1-amide) 204-613-6 123-26-2
Sub-chronic toxicity (90 day): oral
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with: “Octadecanoic acid, 12-hydroxy-, reaction products with ethylenediamine”, CAS 100545-48-0
Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates
30/09/2015
30/09/2015
30/09/2015
16/11/2015
16/11/2015
16/11/2015
Poly[oxy(methyl-1,2-ethanediyl)], a-hydro-omega-hydroxy-, ether with 2,6 bis{[(2-hydroxyethyl)amino]methyl}-4-nonylphenol 614-668-1 68610-97-9
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
30/09/2015
30/09/2015
16/11/2015
16/11/2015
2,2'-[oxybis(methylene)]-bis[2-ethylpropane-1,3-diol] 245-509-0 23235-61-2 Sub-chronic toxicity (90-day): oral 30/09/2015 16/11/2015
dihydro-3-(tripropenyl)furan-2,5-dione 295-556-6 92077-08-2 Reproductive toxicity (pre-natal developmental toxicity) 30/09/2015 16/11/2015
sodium toluene-4-sulphonate 211-522-5 657-84-1 Reproductive toxicity (extended one-generation reproductive toxicity study) 30/09/2015 16/11/2015
tetraethylammonium hydroxide 201-073-3 77-98-5 Sub-chronic toxicity (90-day): oral || Note: testing proposed with N,N,N-trimethylmethanaminium chloride (EC 200-880-8; CAS 75-57-0) 30/09/2015 16/11/2015
Esterification products of 4,4'-Isopropylidenediphenol, ethoxylated and prop-2-enoic acid and 3,5,5-trimethylhexanoic acide 919-846-5 -
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with an analogous substance
31/08/2015
31/08/2015
15/10/2015
15/10/2015
Tri(isopropyl)silyl acrylate 457-670-6 157859-20-6
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
31/08/2015
31/08/2015
15/10/2015
15/10/2015
Tri(isopropyl)silyl acrylate 457-670-6 157859-20-6
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
31/08/2015
31/08/2015
15/10/2015
15/10/2015
3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one 241-753-7 17772-51-9 Reproductive toxicity (pre-natal developmental toxicity) 31/08/2015 15/10/2015
N,N'-(methylenedi-p-phenylene)bis[hexahydro-2-oxo-1H-azepine-1-carboxamide] 258-981-8 54112-23-1 Long-term toxicity to fish
Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates.
31/08/2015 15/10/2015
trimethoxyoctylsilane 221-338-7 3069-40-7 Sub-chronic toxicity (90-day): oral || Note: testing proposed with triethoxy(2,4,4-trimethylpentyl)silane (CAS 35435-21-3) 07/08/2015 22/09/2015
Urea, N-octyl-N'-[4-[[4-[[(octylamino)carbonyl]amino]phenyl]methyl]phenyl]-Urea, N-[4-[[4[(octadecylamino)carbonyl]amino]phenyl]methyl]phenyl]-N’-octyl 445-760-8 -
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
31/07/2015
31/07/2015
14/09/2015
14/09/2015
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol 204-137-9 116-37-0 Reproductive toxicity (pre-natal developmental toxicity) 31/07/2015 14/09/2015
Reaction mass of 1-(2,3-epoxypropoxy)-2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane 608-489-8 30499-70-8
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
25/06/2015
25/06/2015
25/06/2015
10/08/2015
10/08/2015
10/08/2015
1,1,1,3,5,5,5-heptamethyltrisiloxane 217-496-1 1873-88-7
Sub-chronic toxicity (90 day): inhalation
Note: testing proposed with 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7.
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with Octamethyltrisiloxane, CAS 107-51-7 and 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7
25/06/2015
25/06/2015
10/08/2015
10/08/2015
1,1,3,3-tetramethyl-1,3-divinyldisiloxane 220-099-6 2627-95-4
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
25/06/2015
25/06/2015
10/08/2015
10/08/2015
4-trans-Propyl-4-trans-vinyl-[1,1-bicylohexyl] 601-409-2 116020-44-1
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
25/06/2015
25/06/2015
10/08/2015
10/08/2015
dichloro(diphenyl)silane 201-251-0 80-10-4
Sub-chronic toxicity (90-day): oral
Note: testing proposed with dimethoxy(diphenyl)silane (EC 229-929-1, CAS 6843-66-9)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with dimethoxy(diphenyl)silane (EC 229-929-1, CAS 6843-66-9)
25/06/2015
25/06/2015
10/08/2015
10/08/2015
dimethoxydiphenylsilane 229-929-1 6843-66-9
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
25/06/2015
25/06/2015
10/08/2015
10/08/2015
N-[3-(dimethoxymethylsilyl)-2-methylpropyl]ethylenediamine 245-642-4 23410-40-4
Sub-chronic toxicity (90-day): oral
Note: Testing proposal is based on concern identified by the registrant. Testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC 217-164-6)
Reproductive toxicity (pre-natal developmental toxicity)
Note: Testing proposal is based on concern identified by the registrant. Testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC 217-164-6)
25/06/2015
25/06/2015
10/08/2015
10/08/2015
N-[3-(dimethoxymethylsilyl)propyl]ethylenediamine 221-336-6 3069-29-2
Sub-chronic toxicity (90-day): oral
Note: testing proposed with N-(3-trimethoxysilyl)propyl)ethylenediamine CAS 1760-24-3.
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with N-(3-trimethoxysilyl)propyl)ethylenediamine CAS 1760-24-3.
25/06/2015
25/06/2015
10/08/2015
10/08/2015
Reaction mass of 6-Amino-5-(4-substituted-sulfophenylazo)-1-hydroxy-2-[2-alkoxy-5-alkyl- (substitutedsulfonyl)-phenylazo]-naphthalene-sulfonic acid, potassium/sodium salt and 6-Amino-1-hydroxy-2-[2-alkoxy-5-alkyl- (substitutedsulfonyl)-phenylazo]-5-[sulfo- (substitutedsulfonyl)-phenylazo]-naphthalene-sulfonic acid, potassium/sodium salt 445-040-3 -
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
25/06/2015
25/06/2015
10/08/2015
10/08/2015
Reaction mass of [[(2-hydroxyethyl)imino]dimethylene]bisphosphonic acid, sodium salt and 4-(Phosphonomethyl)-2-hydroxy-2-oxo-1,4,2-oxazaphosphorinane, sodium salt 939-513-8 -
Sub-chronic toxicity (90-day): oral
Note: testing proposed either the registered substance or a read-across substance, which would be the acid form of the registered substance
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed either the registered substance or a read-across substance, which would be the acid form of the registered substance
25/06/2015
25/06/2015
10/08/2015
10/08/2015
trichloro(hexadecyl)silane 227-575-2 5894-60-0
Sub-chronic toxicity (90-day): oral
Note: testing proposed with hexadecyl(trimethoxy)silane (EC 240-464-3, CAS 16415-12-6)
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with hexadecyl(trimethoxy)silane (EC 240-464-3, CAS 16415-12-6)
25/06/2015
25/06/2015
10/08/2015
10/08/2015
Ureidopropyltrialkoxysilane 449-160-7 116912-64-2
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
25/06/2015
25/06/2015
10/08/2015
10/08/2015
1,1'-dithiobis[hexahydro-2H-azepin-2-one] 245-910-0 23847-08-7 Reproductive toxicity (pre-natal developmental toxicity) 25/06/2015 10/08/2015
A mixture of: cis-tetrahydro-2-isobutyl-4-methylpyran-4-ol; trans-tetrahydro-2-isobutyl-4-methylpyran-4-ol 405-040-6 63500-71-0 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/06/2015 10/08/2015
Aluminum, benzoate C16-18-fatty acids complexes 303-385-6 94166-87-7 Reproductive toxicity (pre-natal developmental toxicity) 25/06/2015 10/08/2015
butan-2-one O,O',O''-(vinylsilylidyne)trioxime 218-747-8 2224-33-1 Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with Butan-2-one O,O',O''-(methylsilylidyne)trioxime (CAS 22984-54-9).
25/06/2015 10/08/2015
dodecamethylpentasiloxane 205-492-2 141-63-9 Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with Decamethyltetrasiloxane (EC 205-491-7).
25/06/2015 10/08/2015
octyltrichlorosilane 226-112-1 5283-66-9 Sub-chronic toxicity (90-day): oral || Note: testing proposed with triethoxy(2,4,4-trimethylpentyl)silane (EC 252-558-1, CAS 35435-21-3) 25/06/2015 10/08/2015
potassium 4-isopropylbenzenesulphonate 629-764-9 164524-02-1 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/06/2015 10/08/2015
Reaction mass of sodium hydrogen N-(1-oxooctadecyl)-L-glutamate and stearic acid 939-201-1 - Reproductive toxicity (pre-natal developmental toxicity) 25/06/2015 10/08/2015
Sodium N-lauroylsarcosinate 205-281-5 137-16-6 Reproductive toxicity (pre-natal developmental toxicity) 25/06/2015 10/08/2015
triethoxy(phenyl)silane 212-305-8 780-69-8 Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with trimethoxy(phenyl)silane (EC 221-066-9, CAS 2996-92-1)
25/06/2015 10/08/2015
trimethoxy(2,4,4-trimethylpentyl)silane 251-995-5 34396-03-7 Sub-chronic toxicity (90-day): oral
Note: testing proposed with triethoxy(2,4,4-trimethylpentyl)silane (EC 252-558-1, CAS 35435-21-3) "
25/06/2015 10/08/2015
6'-(dibutylamino)-3'-methyl-2'-(phenylamino)spiro[isobenzofuran-1(3H),9-(9H)-xanthen]-3-one 403-830-5 89331-94-2 Bioaccumulation aquatic / sediment 12/06/2015 27/07/2015
[[(phosphonomethyl)imino]bis[hexamethylenenitrilobis(methylene)]]tetrakisphosphonic acid 252-156-6 34690-00-1
Sub-chronic toxicity (90-day): oral || Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant.
20/05/2015
20/05/2015
06/07/2015
06/07/2015
Phosphoric acid, mixed esters with Bu alc. and ethylene glycol 284-716-0 84962-20-9
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphoric acid, butyl ester; CAS No. 12788-93-1
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphoric acid, butyl ester; CAS No. 12788-93-1
20/05/2015
20/05/2015
06/07/2015
06/07/2015
Reaction mass of methyl dihydrogen phosphate and orthophosphoric acid and dimethyl hydrogen phosphate 908-996-7 -
Sub-chronic toxicity (90-day): oral || Note: Testing is proposed with Phosphoric acid, butyl ester (CAS 12788-93-1).
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing is proposed with Phosphoric acid, butyl ester (CAS 12788-93-1).
20/05/2015
20/05/2015
06/07/2015
06/07/2015



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