Previous Testing Proposals
Previous Testing Proposals
Previous Testing Proposals
This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.
To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.
Resin acids and Rosin acids, hydrogenated, esters with triethylene glycol | 271-996-4 | 68648-53-3 |
Reproductive toxicity (pre-natal developmental toxicity)|| Note: Testing proposed to be carried out with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5) and Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9) Sub-chronic toxicity (90-day): oral || Note: Testing proposed with Rosin, methyl ester (CAS RN 68186-14-1), Rosin, ethylene glycol ester (CAS RN 68512-65-2) and Rosin, triethylene glycol ester (CAS RN 8050-25-7) |
02/07/2013 02/07/2013 |
16/08/2013 16/08/2013 |
Details | |
Poly[oxy(methyl-1,2-ethanediyl)], a-hydro-omega-hydroxy-, ether with 2,6 bis{[(2-hydroxyethyl)amino]methyl}-4-nonylphenol | 614-668-1 | 68610-97-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
30/09/2015 30/09/2015 |
16/11/2015 16/11/2015 |
Details | |
9-Octadecenoic acid (Z)-, sulfonated, potassium salts | 271-843-1 | 68609-93-8 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
16/02/2015 16/02/2015 16/02/2015 |
02/04/2015 02/04/2015 02/04/2015 |
Details | |
1-Hexanol, 2-ethyl-, manuf. of, by-products from, distn. residues | 271-832-1 | 68609-68-7 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 26/03/2018 | 11/05/2018 | Details | |
1-Hexanol, 2-ethyl-, manuf. of, by-products from, distn. residues | 271-832-1 | 68609-68-7 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2011 15/07/2011 15/07/2011 |
29/08/2011 29/08/2011 29/08/2011 |
Details | |
Acetic acid, chloro-, sodium salt, reaction products with 4,5-dihydro-2-undecyl-1H-imidazole-1-ethanol and sodium hydroxide | 271-794-6 | 68608-66-2 | Long-term toxicity to fish | 18/02/2014 | 04/04/2014 | Details | |
Acetic acid, chloro-, sodium salt, reaction products with 4,5-dihydro-2-undecyl-1H-imidazole-1-ethanol and sodium hydroxide | 271-794-6 | 68608-66-2 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Alkylamidoamine glycinate majority C12, 14 (amphoacetate) EC 931-291-0
|| Note: Testing proposal is based on concern identified by the registrant Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Alkylamidoamine glycinate majority C12, 14 (amphoacetate) EC 931-291-0.
|| Note: Testing proposal is based on concern identified by the registrant |
19/10/2020 19/10/2020 |
03/12/2020 03/12/2020 |
Details | |
Acetic acid, chloro-, sodium salt, reaction products with 4,5-dihydro-2-undecyl-1H-imidazole-1-ethanol and sodium hydroxide | 271-794-6 | 68608-66-2 | Long-term toxicity to fish Sub-chronic toxicity (90-day): oral || Note: testing proposed with Reaction products of 1H-Imidazole- 1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid (EC 931-291-0) Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid (EC 931-291-0 | 29/02/2016 | 14/04/2016 | Details | |
Carboxylic acids, di-, C4-6 | 271-678-5 | 68603-87-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with adipic acid (EC 204-673-3) | 21/10/2021 | 07/12/2021 | Details | |
Alkanes, C12-14-iso- | 271-369-5 | 68551-19-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Hydrocarbons, C7-C9, isoalkanes (EC 921-728-3)
|| Note: testing proposed with Isohexadecane 2,2,4,4,6,8,8-heptamethylnonane (EC 224-506-8) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Hydrocarbons, C7-C9, isoalkanes (EC 921-728-3)
|| Note: testing proposed with Isohexadecane 2,2,4,4,6,8,8-heptamethylnonane (EC 224-506-8) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Hydrocarbons, C7-C9, isoalkanes (EC 921-728-3)
|| Note: testing proposed with Isohexadecane 2,2,4,4,6,8,8-heptamethylnonane (EC 224-506-8) |
23/11/2020 23/11/2020 23/11/2020 |
07/01/2021 07/01/2021 07/01/2021 |
Details | |
Alkanes, C10-13-iso- | 271-366-9 | 68551-17-7 | Reproductive toxicity (two-generation reproductive toxicity) | 25/06/2012 | 09/08/2012 | Details | |
Dodecene, hydroformylation products, low-boiling | 271-240-3 | 68526-92-1 | Sub-chronic toxicity (90-day): oral | 29/04/2014 | 13/06/2014 | Details | |
Dodecene, hydroformylation products, low-boiling | 271-240-3 | 68526-92-1 | Reproductive toxicity (pre-natal developmental toxicity) | 01/09/2017 | 16/10/2017 | Details | |
Dodecene, hydroformylation products, high boiling | 271-239-8 | 68526-91-0 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2011 15/07/2011 15/07/2011 |
29/08/2011 29/08/2011 29/08/2011 |
Details | |
Octene, hydroformylation products, high-boiling | 271-237-7 | 68526-89-6 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2011 15/07/2011 15/07/2011 |
29/08/2011 29/08/2011 29/08/2011 |
Details | |
Octene, hydroformylation products, high-boiling | 271-237-7 | 68526-89-6 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 23/04/2018 | 07/06/2018 | Details | |
ALCOHOLS, C11-14-ISO-, C13-RICH | 271-235-6 | 68526-86-3 | Sub-chronic toxicity (90-day): oral | 31/05/2016 | 15/07/2016 | Details | |
Alcohols, C11-14-iso-, C13-rich | 271-235-6 | 68526-86-3 | Reproductive toxicity (pre-natal developmental toxicity) | 21/12/2021 | 04/02/2022 | Details | |
Alcohols, C11-14-iso-, C13-rich | 271-235-6 | 68526-86-3 | Reproductive toxicity (pre-natal developmental toxicity) | 27/05/2019 | 11/07/2019 | Details | |
ALCOHOLS, C7-9-ISO-, C8-RICH | 271-231-4 | 68526-83-0 | Sub-chronic toxicity (90-day): oral | 31/05/2016 | 15/07/2016 | Details | |
Alkenes, C8-10, C9-rich | 271-212-0 | 68526-55-6 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
29/07/2011 29/07/2011 25/06/2012 |
12/09/2011 12/09/2011 09/08/2012 |
Details | |
Naphtha (petroleum), steam-cracked middle arom. | 271-138-9 | 68516-20-1 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: This substance belongs to a category. Testing proposed with Extracts (petroleum), heavy naphtha solvent (EC 265-099-7) and Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction (EC 270-728-3) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: This substance belongs to a category. Testing proposed with Extracts (petroleum), heavy naphtha solvent (EC 265-099-7) and Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction (EC 270-728-3) Sub-chronic toxicity (90-day): oral
|| Note: This substance belongs to a category. Testing proposed with Extracts (petroleum), heavy naphtha solvent (EC 265-099-7) and Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction (EC 270-728-3) |
22/04/2021 22/04/2021 22/04/2021 |
07/06/2021 07/06/2021 07/06/2021 |
Details | |
1,2-Benzenedicarboxylic acid, benzyl C7-9-branched and linear alkyl esters | 271-082-5 | 68515-40-2 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
16/06/2011 16/06/2011 |
01/08/2011 01/08/2011 |
Details | |
Resin acids and Rosin acids, esters with ethylene glycol | 270-986-7 | 68512-65-2 | Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, ethylene glycol ester (CAS RN 68512-65-2) | 02/07/2013 | 16/08/2013 | Details | |
Phenol, methylstyrenated | 270-966-8 | 68512-30-1 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
29/07/2011 29/07/2011 |
12/09/2011 12/09/2011 |
Details | |
Diethylmethylbenzenediamine | 270-877-4 | 68479-98-1 | Long-term toxicity to fish | 04/12/2023 | 18/01/2024 | Details | |
Diethylmethylbenzenediamine | 270-877-4 | 68479-98-1 | Reproductive toxicity (pre-natal developmental toxicity) | 29/07/2011 | 12/09/2011 | Details | |
Boron, (benzenemethanamine)trifluoro-, (T-4)-, reaction products with Bu glycidyl ether | 270-821-9 | 68478-46-6 | Genetic toxicity in vivo | 03/05/2023 | 19/06/2023 | Details | |
Distillates (petroleum), cracked stripped steam-cracked petroleum distillates, C8-10 fraction | 270-728-3 | 68477-39-4 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: The substance belongs to a category (“Low Benzene Naphthas”). Testing is proposed with this substance and with Extracts (petroleum), heavy naphtha solvent (EC 265-099-7) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: The substance belongs to a category (“Low Benzene Naphthas”). Testing is proposed with this substance and with Extracts (petroleum), heavy naphtha solvent (EC 265-099-7) Sub-chronic toxicity (90-day): oral
|| Note: The substance belongs to a category (“Low Benzene Naphthas”). Testing is proposed with this substance and with Extracts (petroleum), heavy naphtha solvent (EC 265-099-7) |
22/04/2021 22/04/2021 22/04/2021 |
07/06/2021 07/06/2021 07/06/2021 |
Details | |
Fuels, diesel, no. 2 | 270-676-1 | 68476-34-6 |
Genetic toxicity in vivo
|| Note: testing proposed with
- Gas oils (petroleum), light vacuum (EC 265-059-9)
- Fuels, diesel (EC 269-822-7)
- Fuel oil, no. 4 (EC 270-673-5)
- Distillates (petroleum), light hydrocracked (EC 265-078-2) Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with
- Gas oils (petroleum), light vacuum (EC 265-059-9)
- Fuel oil, no. 4 (EC 270-673-5)
- Distillates (petroleum), light hydrocracked (EC 265-078-2)
- Fuels, diesel (EC 269-822-7) Sub-chronic toxicity (90 day): dermal
|| Note: testing proposed with
- Gas oils (petroleum), light vacuum (EC 265-059-9)
- Fuel oil, no. 4 (EC 270-673-5)
- Distillates (petroleum), light hydrocracked (EC 265-078-2) |
07/07/2020 07/07/2020 07/07/2020 07/07/2020 |
21/08/2020 21/08/2020 21/08/2020 21/08/2020 |
Details | |
Fuels, diesel, no. 2 | 270-676-1 | 68476-34-6 | Reproductive toxicity (two-generation reproductive toxicity) | 15/07/2011 | 29/08/2011 | Details | |
Fuel oil, no. 4 | 270-673-5 | 68476-31-3 | Reproductive toxicity (two-generation reproductive toxicity) | 16/08/2011 | 30/09/2011 | Details | |
Fuel oil, no. 4 | 270-673-5 | 68476-31-3 |
Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Gas oils (petroleum), light vacuum, (EC 265-059-9) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): dermal |
07/07/2020 07/07/2020 07/07/2020 07/07/2020 |
21/08/2020 21/08/2020 21/08/2020 21/08/2020 |
Details | |
Fuel oil, no. 2 | 270-671-4 | 68476-30-2 | Reproductive toxicity (two-generation reproductive toxicity) | 15/07/2011 | 29/08/2011 | Details | |
Fuel oil, no. 2 | 270-671-4 | 68476-30-2 |
Genetic toxicity in vivo
|| Note: testing proposed with
- Gas oils (petroleum), light vacuum (EC 265-059-9)
- Fuels, diesel (EC 269-822-7)
- Fuel oil, no. 4 (EC 270-673-5)
- Distillates (petroleum), light hydrocracked (EC 265-078-2) Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with
- Gas oils (petroleum), light vacuum (EC 265-059-9)
- Fuel oil, no. 4 (EC 270-673-5)
- Distillates (petroleum), light hydrocracked (EC 265-078-2)
- Fuels, diesel (EC 269-822-7) Sub-chronic toxicity (90 day): dermal
|| Note: testing proposed with
- Gas oils (petroleum), light vacuum (EC 265-059-9)
- Fuel oil, no. 4 (EC 270-673-5)
- Distillates (petroleum), light hydrocracked (EC 265-078-2) |
07/07/2020 07/07/2020 07/07/2020 07/07/2020 |
21/08/2020 21/08/2020 21/08/2020 21/08/2020 |
Details | |
Fatty acids, C18-unsatd., dimers, oligomeric reaction products with 1-chloro-2,3-epoxypropane | 500-215-4 | 68475-94-5 | Genetic toxicity in vivo | 18/02/2021 | 05/04/2021 | Details | |
Flue dust, portland cement | 270-659-9 | 68475-76-3 |
Genetic toxicity in vivo Sub-chronic toxicity (90 day): inhalation |
16/08/2011 16/08/2011 |
30/09/2011 30/09/2011 |
Details | |
Resin acids and Rosin acids, polymd., esters with glycerol | 614-523-2 | 68475-37-6 |
Reproductive toxicity (pre-natal developmental toxicity), || Note: testing proposed with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5), Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9) Sub-chronic toxicity (90-day): oral || Note: testing proposed with Rosin, methyl ester (CAS RN 68186-14-1), Rosin, ethylene glycol ester (CAS RN 68512-65-2), Rosin, triethylene glycol ester (CAS RN 8050-25-7) |
02/07/2013 02/07/2013 |
16/08/2013 16/08/2013 |
Details | |
1-isopropyl-2,2-dimethyltrimethylene diisobutyrate | 229-934-9 | 6846-50-0 | Reproductive toxicity (pre-natal developmental toxicity) | 14/03/2016 | 28/04/2016 | Details | |
Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts | 270-608-0 | 68457-79-4 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
01/09/2016 01/09/2016 01/09/2016 |
17/10/2016 17/10/2016 17/10/2016 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts | 270-608-0 | 68457-79-4 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with the substance, with Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with the substance, with Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5) |
21/12/2021 21/12/2021 21/12/2021 |
04/02/2022 04/02/2022 04/02/2022 |
Details | |
Cobalt, borate neodecanoate complexes | 270-601-2 | 68457-13-6 | Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) | 21/01/2021 | 08/03/2021 | Details | |
Cobalt, borate neodecanoate complexes | 270-601-2 | 68457-13-6 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
02/09/2011 02/09/2011 02/09/2011 |
17/10/2011 17/10/2011 17/10/2011 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu) esters, zinc salts | 270-478-5 | 68442-22-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category" Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“ |
04/10/2018 04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 19/11/2018 |
Details | |
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu) esters, zinc salts | 270-478-5 | 68442-22-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) and another relevant read-across member of the ZDDP category Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), and Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5) |
21/12/2021 21/12/2021 21/12/2021 |
04/02/2022 04/02/2022 04/02/2022 |
Details | |
2-Butyne-1,4-diol, polymer with 2-(chloromethyl)oxirane, brominated, dehydrochlorinated, methoxylated | 614-503-3 | 68441-62-3 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposed on rabbit. Reproductive toxicity (two-generation reproductive toxicity) |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
2-Butyne-1,4-diol, polymer with 2-(chloromethyl)oxirane, brominated, dehydrochlorinated, methoxylateddehydrochlorinated, methoxylated | 614-503-3 | 68441-62-3 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 28/02/2018 | 16/04/2018 | Details | |
Resin acids and Rosin acids, magnesium salts | 270-461-2 | 68440-56-2 |
Reproductive toxicity (pre-natal developmental toxicity)|| Note: testing proposed with Rosin (CAS 8050-09-7) Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with Rosin (CAS 8050-09-7) Sub-chronic toxicity (90-day): oral || Note: testing proposed with Rosin (CAS 8050-09-7); Rosin, hydrogenated (CAS 65997-06-0); and Rosin, reaction products with formaldehyde (CAS 91081-53-7) |
02/07/2013 02/07/2013 02/07/2013 |
16/08/2013 16/08/2013 16/08/2013 |
Details | |
Resin acids and Rosin acids, magnesium salts | 270-461-2 | 68440-56-2 | Reproductive toxicity (pre-natal developmental toxicity) | 06/03/2012 | 20/04/2012 | Details | |
Alcohols, C12-14, ethoxylated | 500-213-3 | 68439-50-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 26/10/2022 | 12/12/2022 | Details | |
dimethoxydiphenylsilane | 229-929-1 | 6843-66-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
Polysulfides, di-tert-nonyl | 270-336-2 | 68425-16-1 | Sub-chronic toxicity (90-day): oral | 06/09/2018 | 22/10/2018 | Details | |
Polysulfides, di-tert-dodecyl | 270-335-7 | 68425-15-0 | Bioaccumulation aquatic / sediment | 16/02/2015 | 02/04/2015 | Details | |
Polysulfides, di-tert-dodecyl | 270-335-7 | 68425-15-0 | Bioaccumulation aquatic / sediment | 01/07/2011 | 15/08/2011 | Details | |
Polysulfides, di-tert-dodecyl | 270-335-7 | 68425-15-0 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 18/03/2021 | 03/05/2021 | Details | |
Polysulfides, di-tert-dodecyl | 270-335-7 | 68425-15-0 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
31/01/2018 31/01/2018 31/01/2018 |
19/03/2018 19/03/2018 19/03/2018 |
Details | |
Fatty acids, lanolin | 270-302-7 | 68424-43-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/08/2011 16/08/2011 |
30/09/2011 30/09/2011 |
Details | |
Cashew, nutshell liq., oligomeric reaction products with 1-chloro-2,3-epoxypropane | - | 68413-24-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2014 15/07/2014 |
29/08/2014 29/08/2014 |
Details | |
Nonylphenol, branched, ethoxylated | 500-209-1 | 68412-54-4 | Reproductive toxicity (two-generation reproductive toxicity) | 29/07/2011 | 12/09/2011 | Details | |
Benzenamine, N-phenyl-, reaction products with 2,4,4-trimethylpentene | 270-128-1 | 68411-46-1 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/10/2017 | 11/12/2017 | Details | |
Benzenamine, N-phenyl-, reaction products with 2,4,4-trimethylpentene | 270-128-1 | 68411-46-1 |
Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity study (90-day): oral |
05/04/2011 05/04/2011 |
20/05/2011 20/05/2011 |
Details | |
Fatty acids, C18-unsatd., dimers, reaction products with polyethylenepolyamines | 614-452-7 | 68410-23-1 |
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (CAS 68082-29-1) Sub-chronic toxicity (90-day): oral || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (CAS 68082-29-1) |
30/11/2015 30/11/2015 |
14/01/2016 14/01/2016 |
Details | |
Fatty acids, C18-unsatd., dimers, reaction products with polyethylenepolyamines | 614-452-7 | 68410-23-1 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine Sub-chronic toxicity (90-day): oral || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine |
28/02/2018 28/02/2018 |
16/04/2018 16/04/2018 |
Details | |
Pyridine, alkyl derivs. | 269-929-9 | 68391-11-7 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 5-ethyl-2-methylpyridine | 04/04/2014 | 19/05/2014 | Details | |
Amides, C16-C18 (even) , N,N'-ethylenebis | 931-299-4 | 68390-94-3 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
01/03/2023 01/03/2023 |
17/04/2023 17/04/2023 |
Details | |
Resin acids and Rosin acids, calcium zinc salts | 269-825-3 | 68334-35-0 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposed with Rosin (CAS 8050-09-7) Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with Rosin (CAS 8050-09-7) Sub-chronic toxicity (90-day): oral || Note: testing proposed with Rosin (CAS 8050-09-7); Rosin, hydrogenated (CAS 65997-06-0); and Rosin, reaction products with formaldehyde (CAS 91081-53-7) |
02/07/2013 02/07/2013 02/07/2013 |
16/08/2013 16/08/2013 16/08/2013 |
Details | |
Resin acids and Rosin acids, calcium zinc salts | 269-825-3 | 68334-35-0 | Reproductive toxicity (pre-natal developmental toxicity) | 06/03/2012 | 20/04/2012 | Details | |
Fuels, diesel | 269-822-7 | 68334-30-5 | Reproductive toxicity (two-generation reproductive toxicity) | 16/08/2011 | 30/09/2011 | Details | |
Fuels, diesel | 269-822-7 | 68334-30-5 |
Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9) Reproductive toxicity (pre-natal developmental toxicity) |
07/07/2020 07/07/2020 07/07/2020 |
21/08/2020 21/08/2020 21/08/2020 |
Details | |
Shale oils | 269-646-0 | 68308-34-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with Shale oils, heavy fractions (Registration No 01-2119756217-35-0000)” Sub-chronic toxicity (90-day): oral “|| Note: testing proposed with Shale oils, heavy fractions (Registration No 01-2119756217-35-0000)” | 14/03/2016 | 28/04/2016 | Details | |
Shale oils | 269-646-0 | 68308-34-9 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
17/11/2011 17/11/2011 17/11/2011 |
02/01/2012 02/01/2012 02/01/2012 |
Details | |
14H-benz[4,5]isoquino[2,1-a]perimidin-14-one | 229-904-5 | 6829-22-7 | Genetic toxicity in vivo | 19/10/2020 | 03/12/2020 | Details | |
Bis(2-chloroethyl) 3,3'-[(2,5-dimethyl-p-phenylene)bis[iminocarbonyl(2-hydroxy-1,3-naphthylene)azo]]di-p-toluate | 269-507-4 | 68259-05-2 | Sub-chronic toxicity (90 day): inhalation || Note: Testing proposal is based on concern identified by the registrant | 24/07/2019 | 09/09/2019 | Details | |
Resin acids and Rosin acids, maleated, sodium salts | 269-228-8 | 68201-60-5 |
Reproductive toxicity (pre-natal developmental toxicity) //Note: Testing proposed with Rosin, fumarated (CAS RN 65997-04-7) and Rosin, maleated (CAS RN 8050-28-0) Reproductive toxicity (two-generation reproductive toxicity) //Note: Testing proposed with Rosin, Fumarated (CAS RN 65997-04-7) Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, fumarated (CAS RN 65997-04-7) and Rosin, maleated (CAS RN 8050-28-0) |
02/07/2013 02/07/2013 02/07/2013 |
16/08/2013 16/08/2013 16/08/2013 |
Details | |
Trimethylolpropane Diallyl Ether / 2,2-bis(allyloxymethyl)butan-1-ol / 2,2-bis[(allyloxy)methyl]butan-1-ol | 211-661-1 | 682-09-7 |
Reproductive toxicity (pre-natal developmental toxicity) subchronic toxicity (90-day) |
26/01/2011 26/01/2011 |
14/03/2011 14/03/2011 |
Details | |
l-Glutamic acid, N-coco acyl derivs., disodium salts | 269-085-1 | 68187-30-4 | Reproductive toxicity (pre-natal developmental toxicity) | 18/09/2014 | 03/11/2014 | Details | |
l-Glutamic acid, N-coco acyl derivs., disodium salts | 269-085-1 | 68187-30-4 | Sub-chronic toxicity (90-day): oral | 22/09/2022 | 07/11/2022 | Details | |
Resin acids and Rosin acids, Me esters | 269-035-9 | 68186-14-1 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposed to be carried out with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5) and Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9) Sub-chronic toxicity (90-day): oral || Note: Testing proposed with Rosin, methyl ester (CAS RN 68186-14-1) |
02/07/2013 02/07/2013 |
16/08/2013 16/08/2013 |
Details | |
Benzene-1,2,4-tricarboxylic acid 1,2-anhydride, oligomeric reaction products with ethane-1,2-diol and glycerol | 500-199-9 | 68183-39-1 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
16/02/2015 16/02/2015 16/02/2015 |
02/04/2015 02/04/2015 02/04/2015 |
Details | |
Fatty acids, C18-unsatd., dimers, polymers with oleic acid and triethylenetetramine | 614-339-2 | 68154-62-1 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (EC 500-191-5, CAS 68082-29-1) Sub-chronic toxicity (90-day): oral || Note: testing proposed with fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (EC 500-191-5, CAS 68082-29-1) |
16/10/2014 16/10/2014 |
01/12/2014 01/12/2014 |
Details | |
Resin acids and Rosin acids, esters with diethylene glycol | 268-884-2 | 68153-38-8 |
Reproductive toxicity (pre-natal developmental toxicity), || Note: testing proposed with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5), Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9) Sub-chronic toxicity (90-day): oral || Note: testing proposed with Rosin, methyl ester (CAS RN 68186-14-1), Rosin, ethylene glycol ester (CAS RN 68512-65-2), Rosin, triethylene glycol ester (CAS RN 8050-25-7) |
02/07/2013 02/07/2013 |
16/08/2013 16/08/2013 |
Details | |
Tall oil, maleated | 268-859-6 | 68152-93-2 |
Bioaccumulation aquatic / sediment Long-term toxicity to fish |
04/10/2018 04/10/2018 |
19/11/2018 19/11/2018 |
Details | |
Amines, tallow alkyl, dodecylbenzenesulfonates | 268-766-0 | 68139-94-6 |
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
30/11/2015 30/11/2015 30/11/2015 |
14/01/2016 14/01/2016 14/01/2016 |
Details | |
Dihydrogen hexahydroxyplatinate, compound with 2-aminoethanol (1:2) | 268-717-3 | 68133-90-4 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 04/10/2018 | 19/11/2018 | Details | |
Dihydrogen hexahydroxyplatinate, compound with 2-aminoethanol (1:2) | 268-717-3 | 68133-90-4 | Genetic toxicity in vivo | 21/12/2021 | 04/02/2022 | Details | |
Amines, polyethylenepoly- | 268-626-9 | 68131-73-7 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 22/11/2017 | 08/01/2018 | Details | |
Amines, polyethylenepoly- | 268-626-9 | 68131-73-7 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 01/09/2017 | 16/10/2017 | Details | |
Amines, polyethylenepoly- | 268-626-9 | 68131-73-7 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
28/02/2011 28/02/2011 |
14/04/2011 14/04/2011 |
Details | |
Polyphosphoric acids, esters with triethanolamine, sodium salts | 268-625-3 | 68131-72-6 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
15/04/2014 15/04/2014 |
30/05/2014 30/05/2014 |
Details | |
Sulfite liquors and Cooking liquors, green | 268-612-2 | 68131-30-6 | Genetic toxicity in vivo | 31/05/2011 | 15/07/2011 | Details | |
Naphthenic acids, reaction products with diethylenetriamine | 268-610-1 | 68131-13-5 | Reproductive toxicity (pre-natal developmental toxicity) | 18/09/2014 | 03/11/2014 | Details | |
Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine | 500-191-5 | 68082-29-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
04/04/2014 04/04/2014 |
19/05/2014 19/05/2014 |
Details | |
Amines, C16-22-alkyl | 268-215-4 | 68037-92-3 | Reproductive toxicity (pre-natal developmental toxicity) | 16/05/2014 | 30/06/2014 | Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with 2-methylimidazole | 500-181-0 | 68002-42-6 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
Mercaptoacetic acid | 200-677-4 | 68-11-1 | Long-term toxicity to fish | 31/01/2023 | 17/03/2023 | Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with fatty acids, C18-unsatd., dimers | 500-180-5 | 67989-52-0 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
02/06/2014 02/06/2014 02/06/2014 |
17/07/2014 17/07/2014 17/07/2014 |
Details | |
orthoboric acid, compound with 2,2'-iminodiethanol | 267-886-0 | 67952-33-4 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with MEA Polyborate Sub-chronic toxicity (90-day): oral || Note: testing proposed with MEA Polyborate |
30/11/2015 30/11/2015 |
14/01/2016 14/01/2016 |
Details | |
[3aR-(3aα,5aβ,9aα,9bβ)]-dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan | 229-861-2 | 6790-58-5 | Long-term toxicity to fish | 22/09/2022 | 07/11/2022 | Details | |
Fatty acids, tall-oil, reaction products with triethanolamine | 267-053-1 | 67784-78-5 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
29/07/2011 29/07/2011 29/07/2011 29/07/2011 |
12/09/2011 12/09/2011 12/09/2011 12/09/2011 |
Details | |
Linseed oil, polymerized | 614-114-9 | 67746-08-1 | Reproductive toxicity (pre-natal developmental toxicity) | 18/09/2014 | 03/11/2014 | Details | |