Previous Testing Proposals
Previous Testing Proposals
Previous Testing Proposals
This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.
To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.
N-(3-aminopropyl)-N`-[3-(C16-18 (evennumbered), C18 unsaturated alkyl amino)propyl]propane-1,3-diamine | 628-862-9 | 1219458-11-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2011 15/07/2011 |
29/08/2011 29/08/2011 |
Details | |
2,6,10-trimethyldodecane | 622-542-2 | 3891-98-3 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 04/04/2014 |
Details | |
2,2'-(C16-18 (evennumbered, C18 unsaturated) alkyl imino) diethanol | 620-540-6 | 1218787-32-6 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 2,2'-(Octadec-9-enylimino) bisethanol, CAS No 25307-17-9 | 14/03/2016 | 28/04/2016 | Details | |
1,4-phenylene bis[(4-phenoxyphenyl)-methanone] | 620-097-9 | 54299-17-1 |
Bioaccumulation aquatic / sediment Long-term toxicity to fish |
22/11/2017 22/11/2017 |
08/01/2018 08/01/2018 |
Details | |
1,4-phenylenebis[(4-phenoxyphenyl)methanone] | 620-097-9 | 54299-17-1 | Bioaccumulation test in Fish, Reproductive toxicity (pre-natal developmental toxicity) | 24/02/2020 | 09/04/2020 | Details | |
2,2'-[hexane-1,6-diylbis(oxymethylene)]dioxirane | 618-939-5 | 933999-84-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/10/2017 | 11/12/2017 | Details | |
Reaction products of hexane-1,6-diol with 2-(chloromethyl)oxirane | 618-939-5 | 933999-84-9 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90 day): dermal |
18/11/2014 18/11/2014 18/11/2014 |
02/01/2015 02/01/2015 02/01/2015 |
Details | |
Renewable hydrocarbons (diesel type fraction) | 618-882-6 | 928771-01-1 | Reproductive toxicity (pre-natal developmental toxicity) | 01/09/2017 | 16/10/2017 | Details | |
Reaction products of di-, tri- and tetra-propoxylated propane-1,2-diol with ammonia | 618-561-0 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) | 28/02/2018 | 16/04/2018 | Details | |
2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene | 618-312-6 | 898566-17-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
31/01/2018 31/01/2018 |
19/03/2018 19/03/2018 |
Details | |
Propanenitrile, 3-[[4-[[5,6(or 6,7)-dichloro-2-benzothiazolyl]azo]phenyl]ethylamino]- | 616-632-0 | 78564-87-1 | Genetic toxicity in vivo | 26/10/2022 | 12/12/2022 | Details | |
Poly(oxy-1,2-ethanediyl), .alpha.-[3-[(carboxymethyl)methylamino]-2-hydroxypropyl]-.omega.-(4-nonylphenoxy)-, monosodium sal | 616-248-3 | 75627-31-5 |
Reproductive toxicity (pre-natal developmental toxicity Sub-chronic toxicity (90-day): oral |
23/12/2015 23/12/2015 |
03/02/2016 03/02/2016 |
Details | |
Reaction products of a polyol of pentaerythritol and propylene oxide, epichlorohydrin and hydrogen sulfide | 615-735-8 | 72244-98-5 |
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant Reproductive toxicity (pre-natal developmental toxicity) |
11/11/2016 11/11/2016 |
03/01/2017 03/01/2017 |
Details | |
Hydrocarbons, C9-unsaturated, polymerized | 615-276-3 | - |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
15/09/2011 15/09/2011 |
31/10/2011 31/10/2011 |
Details | |
Alcohols, C8-10, ethoxylated | 615-247-5 | 71060-57-6 |
Long-term toxicity to fish Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
22/09/2022 22/09/2022 22/09/2022 |
07/11/2022 07/11/2022 07/11/2022 |
Details | |
Poly[oxy(methyl-1,2-ethanediyl)], a-hydro-omega-hydroxy-, ether with 2,6 bis{[(2-hydroxyethyl)amino]methyl}-4-nonylphenol | 614-668-1 | 68610-97-9 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
30/09/2015 30/09/2015 |
16/11/2015 16/11/2015 |
Details | |
Amines, N-tallow alkyltrimethylenedi-, propoxylated | 614-637-2 | - |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/08/2011 16/08/2011 |
30/09/2011 30/09/2011 |
Details | |
Resin acids and Rosin acids, polymd., esters with glycerol | 614-523-2 | 68475-37-6 |
Reproductive toxicity (pre-natal developmental toxicity), || Note: testing proposed with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5), Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9) Sub-chronic toxicity (90-day): oral || Note: testing proposed with Rosin, methyl ester (CAS RN 68186-14-1), Rosin, ethylene glycol ester (CAS RN 68512-65-2), Rosin, triethylene glycol ester (CAS RN 8050-25-7) |
02/07/2013 02/07/2013 |
16/08/2013 16/08/2013 |
Details | |
2-Butyne-1,4-diol, polymer with 2-(chloromethyl)oxirane, brominated, dehydrochlorinated, methoxylated | 614-503-3 | - |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): inhalation |
15/04/2011 15/04/2011 15/04/2011 |
30/05/2011 30/05/2011 30/05/2011 |
Details | |
2-Butyne-1,4-diol, polymer with 2-(chloromethyl)oxirane, brominated, dehydrochlorinated, methoxylated | 614-503-3 | 68441-62-3 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposed on rabbit. Reproductive toxicity (two-generation reproductive toxicity) |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
2-Butyne-1,4-diol, polymer with 2-(chloromethyl)oxirane, brominated, dehydrochlorinated, methoxylateddehydrochlorinated, methoxylated | 614-503-3 | 68441-62-3 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 28/02/2018 | 16/04/2018 | Details | |
Fatty acids, C18-unsatd., dimers, reaction products with polyethylenepolyamines | 614-452-7 | 68410-23-1 |
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (CAS 68082-29-1) Sub-chronic toxicity (90-day): oral || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (CAS 68082-29-1) |
30/11/2015 30/11/2015 |
14/01/2016 14/01/2016 |
Details | |
Fatty acids, C18-unsatd., dimers, reaction products with polyethylenepolyamines | 614-452-7 | 68410-23-1 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine Sub-chronic toxicity (90-day): oral || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine |
28/02/2018 28/02/2018 |
16/04/2018 16/04/2018 |
Details | |
Fatty acids, C18-unsatd., dimers, polymers with oleic acid and triethylenetetramine | 614-339-2 | 68154-62-1 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (EC 500-191-5, CAS 68082-29-1) Sub-chronic toxicity (90-day): oral || Note: testing proposed with fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (EC 500-191-5, CAS 68082-29-1) |
16/10/2014 16/10/2014 |
01/12/2014 01/12/2014 |
Details | |
Linseed oil, polymerized | 614-114-9 | 67746-08-1 | Reproductive toxicity (pre-natal developmental toxicity) | 18/09/2014 | 03/11/2014 | Details | |
Resin acids and Rosin acids, polymd., esters with pentaerythritol | 613-868-6 | 65997-12-8 |
Reproductive toxicity (pre-natal developmental toxicity), || Note: Testing proposed to be carried out with Rosin, hydrogenated methyl ester (CAS RN 8050-15-5) and Rosin, hydrogenated glycerol ester (CAS RN 65997-13-9) Sub-chronic toxicity (90-day): oral || Note: Testing proposed with Rosin, methyl ester (CAS RN 68186-14-1), Rosin, ethylene glycol ester (CAS RN 68512-65-2) and Rosin, triethylene glycol ester (CAS RN 8050-25-7) |
02/07/2013 02/07/2013 |
16/08/2013 16/08/2013 |
Details | |
Poly [oxy(methyl-1,2-ethanediyl)] , a -hydro-w -hydroxy-, ether with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol (3:1), 3-[[3-dimethylamino) propyl]imino]butanoate | 613-645-3 | 646505-36-4 | Reproductive toxicity (pre-natal developmental toxicity) | 15/07/2014 | 29/08/2014 | Details | |
Esterification products of 4,4'-isopropylidenediphenol, ethoxylated and prop-2-enoic acid. | 613-584-2 | 64401-02-1 | Genetic toxicity in vivo | 03/02/2016 | 21/03/2016 | Details | |
Esterification products of 4,4'-isopropylidenediphenol, ethoxylated and prop-2-enoic acid. | 613-584-2 | 64401-02-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/11/2014 18/09/2014 |
02/01/2015 03/11/2014 |
Details | |
N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]-2-methyl-prop-2-enamide | 611-915-5 | 59941-98-9 | Genetic toxicity in vivo | 22/04/2021 | 07/06/2021 | Details | |
Oligomerisation reaction products of glyoxal and urea | 610-945-6 | 53037-34-6 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
03/03/2014 03/03/2014 |
17/04/2014 17/04/2014 |
Details | |
Poly[oxy(methyl-1,2-ethanediyl)], α,α'-(2,2-dimethyl-1,3-propanediyl)bis[ω-hydroxy-] | 610-848-9 | 52479-58-0 | Sub-chronic toxicity (90-day): oral | 18/09/2014 | 03/11/2014 | Details | |
Isononyl isononanoate | 609-993-0 | 42131-25-9 | Sub-chronic toxicity (90-day): oral | 18/09/2014 | 03/11/2014 | Details | |
D-glucopyranose, oligomeric, C10-16 glycosides (even numbered), carboxymethyl ethers, sodium salts | 609-542-8 | 383178-66-3 | Reproductive toxicity (pre-natal developmental toxicity) | 30/11/2015 | 14/01/2016 | Details | |
2-Propyn-1-ol, compd. with methyloxirane | 609-530-2 | 38172-91-7 | Sub-chronic toxicity (90-day): oral | 16/10/2014 | 01/12/2014 | Details | |
2-Oxepanone, polymer with 1,6-hexanediol | 609-271-5 | 36609-29-7 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 2-Oxepanone, polymer with 1,4-butanediol Sub-chronic toxicity (90-day): oral || Note: testing proposed with 2-Oxepanone, polymer with 1,4-butanediol |
16/10/2014 16/10/2014 |
01/12/2014 01/12/2014 |
Details | |
Propanamide, 2-hydroxy-N,N-dimethyl- | 609-066-0 | 35123-06-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 21/10/2021 | 07/12/2021 | Details | |
Propanamide, 2-hydroxy-N,N-dimethyl- | 609-066-0 | 35123-06-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 18/03/2021 | 03/05/2021 | Details | |
2-benzofuran-1,3-dione; 2-(2-hydroxyethoxy)ethanol | 608-744-3 | 32472-85-8 | Reproductive toxicity (pre-natal developmental toxicity) | 16/03/2015 | 30/04/2015 | Details | |
Hydroxyethylated 2-butyne-1,4-diol | 608-711-3 | 32167-31-0 | Sub-chronic toxicity (90-day): oral | 17/06/2014 | 01/08/2014 | Details | |
2-Oxepanone, polymer with 1,4-butanediol | 608-670-1 | 31831-53-5 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/05/2014 16/05/2014 |
30/06/2014 30/06/2014 |
Details | |
BICYCLO[3.1.1]HEPT-2-ENE,2,6,6-TRIMETHYL-,POLYMER WITH 6,6-DIMETHYL-2-METHYLENEBICYCLO[3.1.1]HEPTANE | 608-613-0 | - | Reproductive toxicity (pre-natal developmental toxicity) | 30/09/2021 | 15/11/2021 | Details | |
Reaction mass of 1-(2,3-epoxypropoxy)-2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane | 608-489-8 | - | Genetic toxicity in vivo | 03/02/2016 | 21/03/2016 | Details | |
Reaction mass of 1-(2,3-epoxypropoxy)-2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane | 608-489-8 | 30499-70-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
25/06/2015 25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 10/08/2015 |
Details | |
Fatty acids, C16-C18 and C18-unsatd., ME esters, epoxidized, reaction products with ethylen glycol | 606-712-3 | 211450-54-3 | Reproductive toxicity (pre-natal developmental toxicity) | 04/04/2014 | 19/05/2014 | Details | |
Fatty acids, tall-oil, reaction products with bisphenol A, epichlorohydrin, glycidyl tolyl ether and triethylenetetramine | 606-078-8 | 186321-96-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
04/04/2014 04/04/2014 |
19/05/2014 19/05/2014 |
Details | |
2-Hydroxy-5-nonyl(branched)-benzaldehyde oxime | 605-717-8 | 174333-80-3 | Long-term toxicity to fish | 22/06/2017 | 07/08/2017 | Details | |
Hexamethylene diisocyanate, oligomerisation product, blocked with 3,5-dimethyl-1H-pyrazole | 605-318-9 | 163206-31-3 | Sub-chronic toxicity (90 day): inhalation | 12/12/2014 | 26/01/2015 | Details | |
Condensation products of dimerised fatty acids, C18-unsaturated, with N,N-dimethyl-1,3-propanediamine and 1,3-propanediamine | 605-296-0 | 162627-17-0 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90 day): oral |
14/08/2014 14/08/2014 14/08/2014 |
28/09/2014 28/09/2014 28/09/2014 |
Details | |
Fatty acids, C16-C18 and C18-unsatd., ME esters, epoxidized | 605-143-8 | 158318-67-3 | Reproductive toxicity (pre-natal developmental toxicity) | 16/05/2014 | 30/06/2014 | Details | |
Disodium; 4-Amino-3-{4-[4-(2,4-diamino-phenylazo)-benzenesulfonylamino]-phenylazo}-5-hydroxy-6-phenylazo-naphthalene-2,7-disulfonate | 605-104-5 | 157577-99-6 | Genetic toxicity in vivo | 26/08/2021 | 11/10/2021 | Details | |
1-Dodecene, dimer with 1-decene, hydrogenated | 604-766-2 | 151006-58-5 |
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: testing proposed with Dec-1-ene, homopolymer, hydrogenated Dec-1-ene, oligomers, hydrogenated (EC 500-183-1), 1-Decene, tetramer, mixed with 1-decene trimer, hydrogenated (EC 614-695-9) and 1-decene, dimer (EC 917-709-4) Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Dec-1-ene, homopolymer, hydrogenated Dec-1-ene, oligomers, hydrogenated (EC 500-183-1), 1-Dodecene, Dimer (EC 814-509-8) and 1-Decene, tetramer, mixed with 1-decene trimer, hydrogenated (EC 614-695-9) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with 1-Decene, tetramer, mixed with 1-decene trimer, hydrogenated (EC 614-695-9) and 1-Dodecene, dimer, hydrogenated (EC 604-768-3) |
01/07/2021 01/07/2021 01/07/2021 |
16/08/2021 16/08/2021 16/08/2021 |
Details | |
Cesium fluoroaluminate | 604-086-6 | 138577-01-2 | Genetic toxicity in vivo | 23/11/2020 | 07/01/2021 | Details | |
Copolymer of benzenamine and formaldehyde, hydrogenated | 603-894-6 | 135108-88-2 | Reproductive toxicity (pre-natal developmental toxicity) | 14/08/2014 | 28/09/2014 | Details | |
Benzene, 1,1'-oxybis-, tetrapropylene derivatives, sulfonated, sodium salts | 601-601-6 | 119345-04-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) with the Rabbit |
27/05/2019 27/05/2019 |
11/07/2019 11/07/2019 |
Details | |
4-trans-Propyl-4-trans-vinyl-[1,1-bicylohexyl] | 601-409-2 | 116020-44-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
Isononanoic acid, C16-18 (even numbered)-alkyl esters | 601-141-6 | 111937-03-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 18/06/2018 | 02/08/2018 | Details | |
Isononanoic acid, C16-18 (even numbered)-alkyl esters | 601-141-6 | 111937-03-2 | Sub-chronic toxicity (90-day): oral | 18/09/2014 | 03/11/2014 | Details | |
Isononanoic acid, C16-18 (even numbered)-alkyl esters | 601-141-6 | 111937-03-2 | Long-term toxicity to fish | 01/04/2022 | 16/05/2022 | Details | |
2-Propenoic acid, (1-methyl-1,2-ethanediyl) bis[oxy(methyl-2,1-ethanediyl)] ester, reaction products with diethylamine | 601-101-8 | 111497-86-0 | Reproductive toxicity (pre-natal developmental toxicity) | 02/06/2014 | 17/07/2014 | Details | |
2-Propenoic acid, 1,1'-[(1-methyl-1,2-ethanediyl)bis[oxy(methyl-2,1-ethanediyl)]] ester, reaction products with diethylamine | 601-101-8 | 111497-86-0 | Sub-chronic toxicity (90-day): oral | 18/02/2021 | 05/04/2021 | Details | |
1,3,2-dioxathiolane 2,2-dioxide | 600-809-4 | 1072-53-3 | Genetic toxicity in vivo || Note: Link to registration dossier not given as the dossier not yet disseminated || Note: Testing proposal is based on concern identified by the registrant. | 24/01/2019 | 11/03/2019 | Details | |
fatty acids, C16 and C18 unsatd., polymers with bisphenol A, Bu glycidyl ether, epichlorohydrin and triethylenetetramine | 600-687-2 | 105839-18-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
1,4-Cyclohexanedimethanol, reaction products with epichlorohydrin | 600-447-7 | 1035218-79-1 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: Link to registration dossier not given as the dossier not yet disseminated Sub-chronic toxicity (90 day): inhalation || Note: Link to registration dossier not given as the dossier not yet disseminated |
23/12/2015 23/12/2015 |
03/02/2016 03/02/2016 |
Details | |
1-Propanone, 2-hydroxy-2-methyl-, 1-(4-C10-13-alkylphenyl) derivs. | 600-033-6 | 1001416-18-7 | Reproductive toxicity (pre-natal developmental toxicity) | 18/02/2021 | 05/04/2021 | Details | |
Copolymer of acetonoxime and 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate | 600-028-9 | 1001254-87-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): dermal |
02/06/2014 02/06/2014 |
17/07/2014 17/07/2014 |
Details | |
Hexafluoropropene, oxidized, oligomers, reduced, fluorinated | 500-537-5 | 161075-00-9 | Bioaccumulation aquatic / sediment | 16/10/2014 | 01/12/2014 | Details | |
Fatty acids, tall oil, oligomeric reaction products with maleic anhydride and rosin, calcium magnesium zinc salts, consisting of mainly calcium, magnesium, zinc salts of maleated rosin, fatty acids and rosin | 500-451-8 | 160901-14-4 |
Reproductive toxicity (pre-natal developmental toxicity) //Note: to be tested with Rosin, maleated (CAS RN 8050-28-0) Reproductive toxicity (two-generation reproductive toxicity) //Note: Testing proposed with Rosin, Fumarated (CAS RN 65997-04-7) Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin, fumarated (CAS RN 65997-04-7) and Rosin, maleated (CAS RN 8050-28-0) |
02/07/2013 02/07/2013 02/07/2013 |
16/08/2013 16/08/2013 16/08/2013 |
Details | |
Fatty acids, tall-oil, oligomeric reaction products with maleic anhydride and rosin, calcium magnesium zinc salts | 500-451-8 | 160901-14-4 | Reproductive toxicity (pre-natal developmental toxicity) | 06/03/2012 | 20/04/2012 | Details | |
Propylidynetrimethanol, ethoxylated, esters with acrylic acid, reaction products with diethylamine | 500-425-6 | 159034-91-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
26/08/2021 26/08/2021 |
11/10/2021 11/10/2021 |
Details | |
Propylidynetrimethanol, ethoxylated, esters with acrylic acid, reaction products with diethylamine | 500-425-6 | 159034-91-0 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 16/12/2020 | 01/02/2021 | Details | |
Alcohols, C16-18 and C18-unsatd., ethoxylated, sulfates, sodium salts | 500-345-1 | 157627-95-7 | Reproductive toxicity (pre-natal developmental toxicity) | 30/06/2023 | 14/08/2023 | Details | |
4,4'-Isopropylidenediphenol, ethoxylated, esters with fatty acids, coco | 500-303-2 | 115340-85-7 | Genetic toxicity in vivo | 21/01/2021 | 08/03/2021 | Details | |
Phenol, 4,4'-(1-methylethylidene)bis-, oligomeric reaction products with 2-(chloromethyl)oxirane, reaction products with 1,3-benzenedimethanamine | 500-302-7 | 113930-69-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/04/2014 15/04/2014 |
30/05/2014 30/05/2014 |
Details | |
4,4'-Methylenediphenyl diisocyanate, oligomeric reaction products with 2,4'-diisocyanatodiphenylmethane | 500-297-1 | 109331-54-6 | Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no. 202-966-0) | 31/01/2023 | 17/03/2023 | Details | |
Fatty acids, C18-unsatd., dimers, oligomeric reaction products with triethylenetetramine | 500-290-3 | 103758-99-2 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (CAS 68082-29-1; EC 500-191-5) Sub-chronic toxicity (90-day): oral || Note: testing proposed with Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (CAS 68082-29-1; EC 500-191-5) |
17/09/2019 17/09/2019 |
01/11/2019 01/11/2019 |
Details | |
Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and tetraethylenepentamine | 500-289-8 | 103758-98-1 |
Reproductive toxicity (pre-natal developmental toxicity) ||Note: testing proposed with [Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine] (CAS 68082-29-1) Sub-chronic toxicity (90-day): oral ||Note: testing proposed with [Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine] (CAS 68082-29-1) |
16/03/2015 16/03/2015 |
30/04/2015 30/04/2015 |
Details | |
3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate, oligomers, reaction products with 2-butanone oxime | 500-287-7 | 103170-26-9 | Sub-chronic toxicity (90 day): inhalation | 12/12/2014 | 26/01/2015 | Details | |
2,3-Epoxypropyl neodecanoate, oligomeric reaction products with toluene-4-sulfonic acid | 500-281-4 | 98362-33-5 |
Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2014 15/07/2014 15/07/2014 |
29/08/2014 29/08/2014 29/08/2014 |
Details | |
Terpenes and terpenoids, turpentine-oil, α-pinene fraction, oligomers. | 500-245-8 | 70750-57-1 | Reproductive toxicity (pre-natal developmental toxicity) | 04/04/2014 | 19/05/2014 | Details | |
Fatty acids, C18-unsatd., dimers, oligomeric reaction products with 1-chloro-2,3-epoxypropane | 500-215-4 | 68475-94-5 | Genetic toxicity in vivo | 18/02/2021 | 05/04/2021 | Details | |
Alcohols, C12-14, ethoxylated | 500-213-3 | 68439-50-9 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 26/10/2022 | 12/12/2022 | Details | |
Nonylphenol, branched, ethoxylated | 500-209-1 | 68412-54-4 | Reproductive toxicity (two-generation reproductive toxicity) | 29/07/2011 | 12/09/2011 | Details | |
Benzene-1,2,4-tricarboxylic acid 1,2-anhydride, oligomeric reaction products with ethane-1,2-diol and glycerol | 500-199-9 | 68183-39-1 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
16/02/2015 16/02/2015 16/02/2015 |
02/04/2015 02/04/2015 02/04/2015 |
Details | |
Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine | 500-191-5 | 68082-29-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
04/04/2014 04/04/2014 |
19/05/2014 19/05/2014 |
Details | |
Fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine | 500-191-5 | - |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
28/02/2018 28/02/2018 |
16/04/2018 16/04/2018 |
Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with 2-methylimidazole | 500-181-0 | 68002-42-6 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with fatty acids, C18-unsatd., dimers | 500-180-5 | 67989-52-0 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
02/06/2014 02/06/2014 02/06/2014 |
17/07/2014 17/07/2014 17/07/2014 |
Details | |
Rosin, oligomers | 500-163-2 | 65997-05-9 | Sub-chronic toxicity (90-day): oral //Note: Testing proposed with Rosin (CAS RN 8050-09-7), Rosin, hydrogenated (CAS RN 65997-06-0), and Rosin, reaction products with formaldehyde (CAS RN 91081-53-7) | 02/07/2013 | 16/08/2013 | Details | |
Formaldehyde, oligomeric reaction products with phenol and m-phenylenebis(methylamine) | 500-137-0 | 57214-10-5 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
30/11/2015 30/11/2015 30/11/2015 |
14/01/2016 14/01/2016 14/01/2016 |
Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, esters with acrylic acid | 500-130-2 | 55818-57-0 | Reproductive toxicity (pre-natal developmental toxicity) | 31/05/2016 | 15/07/2016 | Details | |
Glycerol, propoxylated, esters with acrylic acid | 500-114-5 | 52408-84-1 | Sub-chronic toxicity (90-day): oral | 22/11/2017 | 08/01/2018 | Details | |
2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane | 500-107-7 | 40039-93-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
27/09/2017 27/09/2017 27/09/2017 |
13/11/2017 13/11/2017 13/11/2017 |
Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with 3-aminomethyl-3,5,5-trimethylcyclohexylamine | 500-101-4 | 38294-64-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/04/2014 15/04/2014 |
30/05/2014 30/05/2014 |
Details | |
2-Oxepanone, polymer with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol | 500-099-5 | 37625-56-2 | Reproductive toxicity (pre-natal developmental toxicity) | 15/07/2011 | 29/08/2011 | Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with maleic anhydride and methacrylic acid | 500-090-6 | 36425-16-8 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with a structurally related substance (small vinyl ester) Sub-chronic toxicity (90-day): oral || Note: testing proposed with a structurally related substance (small vinyl ester) |
31/05/2016 31/05/2016 |
15/07/2016 15/07/2016 |
Details | |
4,4`-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with methacrylic acid | 500-089-0 | 36425-15-7 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
01/07/2011 01/07/2011 01/07/2011 |
15/08/2011 15/08/2011 15/08/2011 |
Details | |
4,4'-Isopropylidenediphenol, ethoxylated | 500-082-2 | 32492-61-8 |
Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
16/06/2022 16/06/2022 16/06/2022 |
01/08/2022 01/08/2022 01/08/2022 |
Details | |
4,4'-Isopropylidenediphenol, ethoxylated | 500-082-2 | - |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
21/05/2018 21/05/2018 21/05/2018 |
05/07/2018 05/07/2018 05/07/2018 |
Details | |
Formaldehyde, oligomeric reaction products with aniline and phosgene | 500-079-6 | 32055-14-4 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC 202-966-0) | 01/04/2022 | 16/05/2022 | Details | |