Previous Testing Proposals

Previous Testing Proposals

Previous Testing Proposals

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

There are currently no ongoing consultations.
 
Dimethyl (p-methoxybenzylidene)malonate 231-185-8 7443-25-6 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 23/03/2020 07/05/2020 Details
N-{2-[(phenylcarbamoyl)amino]phenyl}benzenesulfonamide 806-543-7 215917-77-4 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 30/11/2015 14/01/2016 Details
(3E)-2-chloro-3-(hydroxymethylene)cyclohexene-1-carbaldehyde 801-656-8 1416808-92-8 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 17/04/2015 04/06/2015 Details
2,2-dimethyl-3-oxopropyl acetate 811-188-6 16184-79-5 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 01/09/2017 16/10/2017 Details
[3-(2,3-epoxypropoxy)propyl]diethoxymethylsilane 220-780-8 2897-60-1 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 16/12/2016 30/01/2017 Details
Copper (2+), bis [N-{amino (imino-KN) methyl} urea-KO]-, nitrate (1:2) 800-038-5 1071838-81-7 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 23/01/2015 09/03/2015 Details
Dialkyl-methyl-dihydro-heteropolycyle 815-131-6 913171-06-9 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 23/03/2020 07/05/2020 Details
Diammonium hexachloroplatinate 240-973-0 16919-58-7 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 23/04/2018 07/06/2018 Details
Dihydrogen hexahydroxyplatinate, compound with 2-aminoethanol (1:2) 268-717-3 68133-90-4 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 04/10/2018 19/11/2018 Details
Dipotassium hexachloroplatinate 240-979-3 16921-30-5 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 26/03/2018 11/05/2018 Details
Everzol Red CDN Crude 483-940-8 - Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 31/01/2018 19/03/2018 Details
Tetraammineplatinum dichloride 237-706-5 13933-32-9 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 28/02/2018 16/04/2018 Details
4-tert-butylpyrocatechol 202-653-9 98-29-3
Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (extended one-generation reproductive toxicity study)
28/02/2018
28/02/2018
16/04/2018
16/04/2018
Details
Hexachloroplatinic acid 241-010-7 16941-12-1 Genetic toxicity in vivo || Note: testing proposed with Diammonium hexachloroplatinate (EC 241-010-7). Testing proposal is based on concern identified by the registrant. 26/03/2018 11/05/2018 Details
Dihydrogen hexahydroxyplatinate 257-471-2 51850-20-5 Genetic toxicity in vivo || Note: Testing proposed with dihydrogen hexahydroxyplatinate(IV), compound with 2-aminoethanol (1:2). Testing proposal is based on concern identified by the registrant. 28/02/2018 16/04/2018 Details
Tetraammineplatinum dinitrate 243-929-9 20634-12-2 Genetic toxicity in vivo || Note: testing proposed with tetraammineplatinum(II) dichloride. Testing proposal is based on concern identified by the registrant. 28/02/2018 16/04/2018 Details
p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline 225-716-2 5026-74-4
Genetic toxicity in vivo || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
15/07/2014
15/07/2014
15/07/2014
15/07/2014
29/08/2014
29/08/2014
29/08/2014
29/08/2014
Details
p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline 225-716-2 5026-74-4
Genetic toxicity in vivo || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with the m-isomer of the substance (CAS 71604-74-5)
15/07/2014
15/07/2014
15/07/2014
15/07/2014
29/08/2014
29/08/2014
29/08/2014
29/08/2014
Details
Propionaldehyde, reaction product with formaldehyde 701-281-9 - Genetic toxicity in vivo || Note: the EC/list number of the substance has been changed. 10/12/2018 24/01/2019 Details
Hexanal 200-624-5 66-25-1 Genetic toxicity in vivo “|| Note: Testing proposal is based on concern identified by the registrant.” 27/05/2019 11/07/2019 Details
4,4'-methylenebis[2,6-diethylaniline] 237-185-4 13680-35-8
Genetic toxicity in vivo
Long-term toxicity to fish
26/03/2018
26/03/2018
11/05/2018
11/05/2018
Details
2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane 219-863-1 2554-06-5
Genetic toxicity in vivo
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): inhalation
03/03/2014
03/03/2014
03/03/2014
03/03/2014
17/04/2014
17/04/2014
17/04/2014
17/04/2014
Details
3-hydroxy-2-(hydroxymethyl)-2-methylpropanal 242-393-3 18516-18-2
Genetic toxicity in vivo
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/06/2011
16/06/2011
16/06/2011
16/06/2011
01/08/2011
01/08/2011
01/08/2011
01/08/2011
Details
[4-[p,p'-bis(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium m-[[p-anilinophenyl]azo]benzenesulphonate 265-449-9 65113-55-5
Genetic toxicity in vivo
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
18/02/2014
18/02/2014
04/04/2014
04/04/2014
04/04/2014
04/04/2014
Details
Reaction mass of N-[2-(2-oxoimidazolidin-1-yl)ethyl]methacrylamide and methacrylic acid 934-058-1 -
Genetic toxicity in vivo
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
16/05/2014
16/05/2014
30/06/2014
30/06/2014
30/06/2014
30/06/2014
Details
Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid - -
Genetic toxicity in vivo
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/08/2011
16/08/2011
16/08/2011
16/08/2011
30/09/2011
30/09/2011
30/09/2011
30/09/2011
Details
Bis(2-chloroethoxy)methane 1,15-dichloro-3,5,8,11,13-penta-oxa pentadecane 1-(2-chloroethoxy)-2-(2-chloroethoxymethoxy)ethane 940-783-4 -
Genetic toxicity in vivo
Long-term toxicity to fish
Reproductive toxicity (two-generation reproductive toxicity) // Note: test to be performed with analogues substance 1-chloro-2-[(2-chloroethoxy)methoxy]ethane (EC 203-920-2 )
02/06/2014
02/06/2014
02/06/2014
17/07/2014
17/07/2014
17/07/2014
Details
3-trimethoxysilylpropyl methacrylate 219-785-8 2530-85-0
Genetic toxicity in vivo
Reproductive toxicity (extended one-generation reproductive toxicity study)
01/09/2017
01/09/2017
16/10/2017
16/10/2017
Details
3-(trimethoxysilyl)propyl isocyanate 239-415-9 15396-00-6
Genetic toxicity in vivo
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: it is proposed to use the information from an ongoing study with 3-(trimethoxysilyl)propylamine (EC 237-511-5)
30/09/2021
30/09/2021
15/11/2021
15/11/2021
Details
Fuels, diesel 269-822-7 68334-30-5
Genetic toxicity in vivo
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9)
Reproductive toxicity (pre-natal developmental toxicity)
07/07/2020
07/07/2020
07/07/2020
21/08/2020
21/08/2020
21/08/2020
Details
Distillates (petroleum), light hydrocracked 265-078-2 64741-77-1
Genetic toxicity in vivo
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Gas oils (petroleum), light vacuum (EC 265-059-9)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): dermal
07/07/2020
07/07/2020
07/07/2020
07/07/2020
21/08/2020
21/08/2020
21/08/2020
21/08/2020
Details
Fuel oil, no. 4 270-673-5 68476-31-3
Genetic toxicity in vivo
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Gas oils (petroleum), light vacuum, (EC 265-059-9)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): dermal
07/07/2020
07/07/2020
07/07/2020
07/07/2020
21/08/2020
21/08/2020
21/08/2020
21/08/2020
Details
4,4'-Isopropylidenediphenol, ethoxylated 500-082-2 32492-61-8
Genetic toxicity in vivo
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
16/06/2022
16/06/2022
16/06/2022
01/08/2022
01/08/2022
01/08/2022
Details
Perfluamine 206-420-2 338-83-0
Genetic toxicity in vivo
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
21/12/2021
21/12/2021
21/12/2021
04/02/2022
04/02/2022
04/02/2022
Details
Gas oils (petroleum), light vacuum 265-059-9 64741-58-8
Genetic toxicity in vivo
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90 day): dermal
Sub-chronic toxicity (90-day): oral
07/07/2020
07/07/2020
07/07/2020
07/07/2020
07/07/2020
21/08/2020
21/08/2020
21/08/2020
21/08/2020
21/08/2020
Details
Asphalt 232-490-9 8052-42-4
Genetic toxicity in vivo
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
04/12/2023
04/12/2023
04/12/2023
04/12/2023
18/01/2024
18/01/2024
18/01/2024
18/01/2024
Details
2-ethylhexyl 10-ethyl-4,4-dimethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate 260-829-0 57583-35-4
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity
Sub-chronic toxicity (90-day): oral
01/09/2016
01/09/2016
01/09/2016
17/10/2016
17/10/2016
17/10/2016
Details
2-ethylanthraquinone 201-535-4 84-51-5
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
18/02/2014
18/02/2014
04/04/2014
04/04/2014
Details
4,6-dichloro-N-(1,1,3,3-tetramethylbutyl)-1,3,5-triazin-2-amine 276-309-1 72058-41-4
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
23/11/2020
23/11/2020
07/01/2021
07/01/2021
Details
arbonohydrazide 207-837-2 497-18-7
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
18/02/2014
18/02/2014
04/04/2014
04/04/2014
Details
Diamminediisocyanatozinc 401-610-3 122012-52-6
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
10/05/2022
10/05/2022
27/06/2022
27/06/2022
Details
dimethoxydimethylsilane 214-189-4 1112-39-6
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
28/11/2022
28/11/2022
12/01/2023
12/01/2023
Details
N-phenyl-N-[(trichloromethyl)thio]benzenesulphonamide 218-915-0 2280-49-1
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
18/02/2014
18/02/2014
04/04/2014
04/04/2014
Details
Polyphosphoric acids, esters with triethanolamine, sodium salts 268-625-3 68131-72-6
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
15/04/2014
15/04/2014
30/05/2014
30/05/2014
Details
Product of Semi-Dry Absorption method of Flue Gas Desulphurization (SDA Product) 931-259-6 -
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
02/09/2011
02/09/2011
17/10/2011
17/10/2011
Details
Reaction mass of 2,2'-[(4-methylphenyl)imino]bisethanol and Ethanol 2-[[2-(2-hydroxyethoxy)ethyl](4-methylphenyl)amino]- 911-490-9 -
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
18/11/2014
18/11/2014
02/01/2015
02/01/2015
Details
2,2`-iminodi(ethylamine),N-(2-aminoethyl)ethane-1,2-diamine 203-865-4 111-40-0
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
05/04/2011
05/04/2011
05/04/2011
20/05/2011
20/05/2011
20/05/2011
Details
Slimes and Sludges, blast furnace and steelmaking 266-006-2 65996-73-8
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
15/09/2011
15/09/2011
15/09/2011
31/10/2011
31/10/2011
31/10/2011
Details
2,2-dimethylpropane-1,3-diyl cyclohex-4-ene-1,2-dicarboxylate 255-180-5 41026-17-9
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
16/05/2014
16/05/2014
30/06/2014
30/06/2014
30/06/2014
30/06/2014
Details
4,4'-Isopropylidenedicyclohexanol, oligomeric reaction products with 1-chloro-2,3-epoxypropane 500-070-7 30583-72-3
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/06/2014
02/06/2014
02/06/2014
02/06/2014
17/07/2014
17/07/2014
17/07/2014
17/07/2014
Details
m-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline 275-662-9 71604-74-5
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2014
15/07/2014
15/07/2014
15/07/2014
29/08/2014
29/08/2014
29/08/2014
29/08/2014
Details
p-tert-butylphenyl 1-(2,3-epoxy)propyl ether 221-453-2 3101-60-8
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
17/06/2014
17/06/2014
17/06/2014
17/06/2014
01/08/2014
01/08/2014
01/08/2014
01/08/2014
Details
Diisopentyl ether 208-857-4 544-01-4
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): inhalation
18/02/2014
18/02/2014
18/02/2014
04/04/2014
04/04/2014
04/04/2014
Details
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol 204-137-9 -
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/01/2012
16/01/2012
16/01/2012
01/03/2012
01/03/2012
01/03/2012
Details
1,3-diphenylpropane-1,3-dione 204-398-9 120-46-7
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/09/2014
18/09/2014
18/09/2014
03/11/2014
03/11/2014
03/11/2014
Details
1,6-hexanediyl-bis(2-(2-(1-ethylpentyl)-3-oxazolidinyl)ethyl)carbamate 925-259-5 140921-24-0
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
16/05/2014
30/06/2014
30/06/2014
30/06/2014
Details
2,2-dimethylpropane-1,3-diyl cyclohex-4-ene-1,2-dicarboxylate  255-180-5 41026-17-9
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/12/2016
16/12/2016
16/12/2016
30/01/2017
30/01/2017
30/01/2017
Details
2-ethylhexyl 10-ethyl-4,4-dimethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate 260-829-0 57583-35-4
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
27/01/2020
27/01/2020
27/01/2020
12/03/2020
12/03/2020
12/03/2020
Details
2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-octyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate 248-227-6 27107-89-7
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2011
16/05/2011
16/05/2011
30/06/2011
30/06/2011
30/06/2011
Details
3-(triethoxysilyl)propanethiol 238-883-1 14814-09-6
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/10/2014
16/10/2014
16/10/2014
01/12/2014
01/12/2014
01/12/2014
Details
3-hydroxy-2,2-dimethylpropyl 3-hydroxy-2,2-dimethylpropionate 214-222-2 1115-20-4
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
31/05/2011
31/05/2011
31/05/2011
15/07/2011
15/07/2011
15/07/2011
Details
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with fatty acids, C18-unsatd., dimers 500-180-5 67989-52-0
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
02/06/2014
02/06/2014
02/06/2014
17/07/2014
17/07/2014
17/07/2014
Details
7-hydroxycitronellal 203-518-7 107-75-5
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
31/01/2023
31/01/2023
31/01/2023
17/03/2023
17/03/2023
17/03/2023
Details
Amino functional alkoxysilanes 701-410-9 -
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/06/2022
16/06/2022
16/06/2022
01/08/2022
01/08/2022
01/08/2022
Details
Bisisobutyryl peroxide 222-340-0 3437-84-1
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
04/04/2014
04/04/2014
04/04/2014
19/05/2014
19/05/2014
19/05/2014
Details
Coconut oil, reaction products with polyethylene glycol and trimethylolpropane 640-964-5 -
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/09/2011
15/09/2011
15/09/2011
31/10/2011
31/10/2011
31/10/2011
Details
di-p-tolyl(2,4,6-trimethylbenzoyl)phosphine oxide 884-585-5 270586-78-2
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
30/06/2023
30/06/2023
30/06/2023
14/08/2023
14/08/2023
14/08/2023
Details
Dimethyl sebacate 203-431-4 106-79-6
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
31/01/2014
31/01/2014
31/01/2014
17/03/2014
17/03/2014
17/03/2014
Details
Formaldehyde, oligomeric reaction products with phenol and m-phenylenebis(methylamine) 500-137-0 57214-10-5
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
30/11/2015
30/11/2015
30/11/2015
14/01/2016
14/01/2016
14/01/2016
Details
Methanal, reaction products with 1,3-bis(aminomethyl)benzene and hydroxybenzen 701-207-5 1950616-36-0
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/05/2018
21/05/2018
21/05/2018
05/07/2018
05/07/2018
05/07/2018
Details
Methyl [3-(trimethoxysilyl)propyl]carbamate 245-659-7 23432-62-4
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
10/03/2017
10/03/2017
10/03/2017
25/04/2017
25/04/2017
25/04/2017
Details
N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isophthalamide 419-710-0 -
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
12/12/2014
12/12/2014
12/12/2014
26/01/2015
26/01/2015
26/01/2015
Details
N,N-dimethyl-N'-(2,2,6,6-tetramethylpiperidin-4-yl)propane-1,3-diamine 278-817-9 78014-16-1
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
26/08/2021
26/08/2021
26/08/2021
11/10/2021
11/10/2021
11/10/2021
Details
N-isopropylhydroxylamine 225-791-1 5080-22-8
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
18/02/2014
04/04/2014
04/04/2014
04/04/2014
Details
OO-tert-butyl O-(2-ethylhexyl) peroxycarbonate 252-029-5 34443-12-4
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/03/2014
21/03/2014
21/03/2014
05/05/2014
05/05/2014
05/05/2014
Details
tert-butyl 2-ethylperoxyhexanoate 221-110-7 3006-82-4
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/04/2011
15/04/2011
15/04/2011
30/05/2011
30/05/2011
30/05/2011
Details
tert-butyl 3,5,5-trimethylperoxyhexanoate 236-050-7 13122-18-4
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/04/2011
15/04/2011
15/04/2011
30/05/2011
30/05/2011
30/05/2011
Details
triethoxy(3-thiocyanatopropyl)silane 252-161-3 34708-08-2
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/10/2014
16/10/2014
16/10/2014
01/12/2014
01/12/2014
01/12/2014
Details
Vinylene carbonate 212-825-5 872-36-6
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
20/05/2021
20/05/2021
20/05/2021
05/07/2021
05/07/2021
05/07/2021
Details
Flue dust, portland cement 270-659-9 68475-76-3
Genetic toxicity in vivo
Sub-chronic toxicity (90 day): inhalation
16/08/2011
16/08/2011
30/09/2011
30/09/2011
Details
Dibutyl itaconate 218-451-9 2155-60-4
Genetic toxicity in vivo
Sub-chronic toxicity (90-day): oral
24/02/2020
24/02/2020
09/04/2020
09/04/2020
Details
Reaction mass of 2-(1,1-dimethylpropyl)anthraquinone and 2-(1,2-dimethylpropyl)anthraquinone 915-623-1 -
Genetic toxicity in vivo
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
04/04/2014
04/04/2014
Details
4-chloroformylphthalic anhydride 214-874-8 1204-28-0 Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant.
27/01/2020 12/03/2020 Details
Diethyl bis(2-hydroxyethyl)aminomethylphosphonate 220-482-8 2781-11-5 Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant.
27/01/2020 12/03/2020 Details
N,N,N',N'-tetrakis(2,3-epoxypropyl)-m-xylene-α,α'-diamine 264-438-6 63738-22-7 Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant.
27/01/2020 12/03/2020 Details
N,N'-diphenyl-p-phenylenediamine 200-806-4 74-31-7
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: Testing proposal is based on concern identified by the registrant.
27/01/2020
27/01/2020
12/03/2020
12/03/2020
Details
triethoxy(3-isocyanatopropyl)silane 246-467-6 24801-88-5 Genetic toxicity in vivo

Note: testing proposed with 3-(Trimethoxysilyl)propyl isocyanate (EC 239-415-9)
03/02/2016 21/03/2016 Details
tetraammine platinum (II) hydrogen carbonate 426-730-3 123439-82-7 Genetic toxicity in vivo|| Note: Testing proposed with tetraammineplatinum(II) dichloride. Testing proposal is based on concern identified by the registrant. 25/10/2017 11/12/2017 Details
Reaction mass of trientine and trientine, mono- and di-propoxylated 942-835-1 - Genetic toxicity in vivo||Note: testing proposed with [Amines, polyethylenepoly-, triethylenetetramine fraction] (EC no. 292-588-2) 03/10/2023 17/11/2023 Details
Residues (petroleum), thermal cracked vacuum 295-518-9 92062-05-0
Genetic toxicity in vivo||Note: testing proposed with Asphalt (EC no. 232-490-9)
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Asphalt (EC no. 232-490-9)
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Asphalt (EC no. 232-490-9)
Sub-chronic toxicity (90-day): oral||Note: testing proposed with Asphalt (EC no. 232-490-9)
04/12/2023
04/12/2023
04/12/2023
04/12/2023
18/01/2024
18/01/2024
18/01/2024
18/01/2024
Details
Residues (petroleum), vacuum 265-057-8 64741-56-6
Genetic toxicity in vivo||Note: testing proposed with Asphalt (EC no. 232-490-9)
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Asphalt (EC no. 232-490-9)
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Asphalt (EC no. 232-490-9)
Sub-chronic toxicity (90-day): oral||Note: testing proposed with Asphalt (EC no. 232-490-9)
04/12/2023
04/12/2023
04/12/2023
04/12/2023
18/01/2024
18/01/2024
18/01/2024
18/01/2024
Details
Reaction products of boric acid and calcium dihydroxide and lithium hydroxide 701-453-3 - Genetic toxicity in vivo||Note: testing proposed with diboron calcium tetraoxide (EC no. 237-224-5) 22/09/2022 07/11/2022 Details
Slimes and Sludges, blast furnace and steelmaking 266-006-2 65996-73-8 Genetic toxicity in vivo||Note: testing proposed with Iron (EC no. 231-096-4), Calcium oxide (EC no. 215-138-9), Magnesium oxide (EC no. 215-171-9), Zinc (EC no. 231-175-3) and Manganese (EC no. 231-105-1) 30/06/2023 14/08/2023 Details
Trimethylamine, N-oxide 214-675-6 1184-78-7 Genetic toxicity in vivo||Note: testing proposed with Reference substance 001 [CAS No. 62637-93-8] 06/06/2023 21/07/2023 Details
2-aminoethanol, monoester with boric acid 233-829-3 10377-81-8
Long-term or reproductive toxicity to birds
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
01/07/2011
01/07/2011
01/07/2011
15/08/2011
15/08/2011
15/08/2011
Details
Orthoboric acid, compound with 2-aminoethanol 247-421-8 26038-87-9
Long-term or reproductive toxicity to birds
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
15/09/2011
15/09/2011
15/09/2011
31/10/2011
31/10/2011
31/10/2011
Details
N-methylaniline 202-870-9 100-61-8
Long-term or reproductive toxicity to birds
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): dermal
01/07/2011
01/07/2011
01/07/2011
01/07/2011
15/08/2011
15/08/2011
15/08/2011
15/08/2011
Details
p-phenylenediammine 203-404-7 106-50-3 Long-term toxicity testing to fish 26/01/2011 14/03/2011 Details
Fatty acids, tall-oil, di- and triesters with trimethylolpropane 941-376-4 -
Long-term toxicity to aquatic invertebrates
Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates.
Testing proposed with EC No 931-531-4.
31/05/2016
31/05/2016
31/05/2016
15/07/2016
15/07/2016
15/07/2016
Details
1,3,3-trimethyl-N-(2-methylpropylidene)-5-[(2-methylpropylidene)amino]cyclohexanemethylamine 259-393-4 54914-37-3 Long-term toxicity to fish 03/10/2023 17/11/2023 Details