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Previous Testing Proposals

Previous Testing Proposals

Previous Testing Proposals

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

 

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Page 4 of 21
100 Items per Page
Showing 301 - 400 of 2,011 results.
Name
EC Number
CAS Number
Hazard endpoint for which vertebrate testing was proposed
Date of publication to call for available information
Deadline for submitting information
Alternatives to vertebrate testing
 
Tetramethylammonium hydroxide 200-882-9 75-59-2 Long-term toxicity to fish 30/06/2023 14/08/2023 Details
Tetramethylammonium hydroxide 200-882-9 75-59-2 Sub-chronic toxicity (90-day): oral
// Note: testing proposed with Tetramethylammonium chloride (EC 200-880-8)
|| Note: Link to justification in the registration dossier not given as the information is confidential 		27/01/2020 12/03/2020 Details
Tetramethylammonium chloride 200-880-8 75-57-0 Sub-chronic toxicity (90-day): oral 29/04/2014 13/06/2014 Details
Nitromethane 200-876-6 75-52-5 Reproductive toxicity (pre-natal developmental toxicity) 04/04/2014 19/05/2014 Details
2-chloropropane 200-858-8 75-29-6 Reproductive toxicity (two-generation reproductive toxicity) 16/05/2011 30/06/2011 Details
2-chloropropane 200-858-8 75-29-6 Reproductive toxicity (extended one-generation reproductive toxicity study) 26/03/2018 11/05/2018 Details
Chloroethane 200-830-5 75-00-3
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
10/03/2017
10/03/2017
25/04/2017
25/04/2017
 Details
2-hydroxy-2-methylpropiophenone 231-272-0 7473-98-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day)
21/10/2019
15/03/2011
15/03/2011
15/03/2011
05/12/2019
29/04/2011
29/04/2011
29/04/2011
 Details
Lithium chloride 231-212-3 7447-41-8 Genetic toxicity in vivo 03/11/2023 18/12/2023 Details
Lithium chloride 231-212-3 7447-41-8 Reproductive toxicity (two-generation reproductive toxicity) 29/04/2011 14/06/2011 Details
tellurium dioxide 231-193-1 7446-07-3 Sub-chronic toxicity (90-day): oral 16/03/2015 30/04/2015 Details
Dimethyl (p-methoxybenzylidene)malonate 231-185-8 7443-25-6 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 23/03/2020 07/05/2020 Details
Bismuth 231-177-4 7440-69-9
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/04/2011
15/04/2011
30/05/2011
30/05/2011
 Details
Cobalt 231-158-0 7440-48-4
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4) || Note: Testing proposal is based on concern identified by the registrant.
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
21/09/2020
21/09/2020
05/11/2020
05/11/2020
 Details
Cobalt 231-158-0 7440-48-4
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/09/2011
02/09/2011
02/09/2011
17/10/2011
17/10/2011
17/10/2011
 Details
Silver 231-131-3 7440-22-4 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with silver(1+) acetate (CAS number 563-63-3) 27/09/2017 13/11/2017 Details
Silver 231-131-3 7440-22-4 Sub-chronic toxicity (90-day): oral 29/04/2011 14/06/2011 Details
Silicon 231-130-8 7440-21-3 Subchronic toxicity (90 day): inhalation 14/02/2011 31/03/2011 Details
Nickel 231-111-4 7440-02-0 Reproductive toxicity (extended one-generation reproductive toxicity study) 28/02/2019 15/04/2019 Details
Methylamine 200-820-0 74-89-5 Genetic toxicity in vivo 14/02/2011 31/03/2011 Details
Ethylene 200-815-3 74-85-1
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
30/09/2021
30/09/2021
15/11/2021
15/11/2021
 Details
N,N'-diphenyl-p-phenylenediamine 200-806-4 74-31-7
Genetic toxicity in vivo
|| Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (extended one-generation reproductive toxicity study)
|| Note: Testing proposal is based on concern identified by the registrant.
27/01/2020
27/01/2020
12/03/2020
12/03/2020
 Details
Butyl glycollate 230-991-7 7397-62-8 Sub-chronic toxicity (90-day): oral 15/04/2011 30/05/2011 Details
2-(2H-Benzotriazol-2-yl)-6-(1-methyl-1-phenylethyl)-4-(1,1,3,3-tetramethylbutyl)phenol 422-600-5 73936-91-1 Bioaccumulation aquatic / sediment 01/04/2022 16/05/2022 Details
Aluminum triformate 230-898-1 7360-53-4
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity study (90-day): oral
21/01/2011
21/01/2011
21/01/2011
07/03/2011
07/03/2011
07/03/2011
 Details
tetrapotassium pyrophosphate 230-785-7 7320-34-5 Sub-chronic toxicity (90 day): inhalation 01/07/2011 15/08/2011 Details
2,4,6-tri-tert-butylphenol 211-989-5 732-26-3 Reproductive toxicity (pre-natal developmental toxicity) 01/07/2021 16/08/2021 Details
Disodium oxybis[methylbenzenesulphonate] 277-242-0 73037-34-0 Reproductive toxicity (pre-natal developmental toxicity) 17/06/2014 01/08/2014 Details
7,7,9(or 7,9,9)-trimethyl-4,13-dioxo-3,14-dioxa-5,12-diazahexadecane-1,16-diyl bismethacrylate 276-957-5 72869-86-4 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 19/10/2020 03/12/2020 Details
5,5'-dithiodi-1,3,4-thiadiazole-2(3H)-thione 276-763-0 72676-55-2
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/12/2020
16/12/2020
01/02/2021
01/02/2021
 Details
5,5'-dithiodi-1,3,4-thiadiazole-2(3H)-thione 276-763-0 72676-55-2 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 20/10/2016 05/12/2016 Details
5,5'-dithiodi-1,3,4-thiadiazole-2(3H)-thione 276-763-0 72676-55-2 Long-term toxicity to fish 30/06/2023 14/08/2023 Details
Reaction products of a polyol of pentaerythritol and propylene oxide, epichlorohydrin and hydrogen sulfide 615-735-8 72244-98-5
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant
Reproductive toxicity (pre-natal developmental toxicity)
11/11/2016
11/11/2016
03/01/2017
03/01/2017
 Details
Iron, complexes with diazotized 5-amino-2-(phenylamino)benzenesulfonic acid monosodium salt coupled with 4-[(2-hydroxy-3,5-dinitrophenyl)azo]-1,3-benzenediol, diazotized 4-nitrobenzenamine and diazotized 3-aminobenzenesulfonic acid monosodium salt 276-464-5 72207-77-3 Genetic toxicity in vivo || Note: testing proposed with Acid Brown 360 (EC 946-788-8) 20/05/2021 05/07/2021 Details
4,6-dichloro-N-(1,1,3,3-tetramethylbutyl)-1,3,5-triazin-2-amine 276-309-1 72058-41-4
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
23/11/2020
23/11/2020
07/01/2021
07/01/2021
 Details
Bis(2,3-epoxypropyl) terephthalate 230-565-0 7195-44-0
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2012
16/05/2012
16/05/2012
02/07/2012
02/07/2012
02/07/2012
 Details
6-[(1-oxomethyloctyl)amino]hexanoic acid 276-173-3 71902-23-3 Reproductive toxicity (pre-natal developmental toxicity) 10/03/2017 25/04/2017 Details
Quaternary ammonium compounds, C12-18-alkylbis(hydroxyethyl)methyl, chlorides 276-038-9 71808-53-2
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2014
15/07/2014
29/08/2014
29/08/2014
 Details
Ethanol, 2,2'-iminobis-, N-C12-18-alkyl derivs. 276-014-8 71786-60-2 Reproductive toxicity (extended one-generation reproductive toxicity study) 25/06/2019 09/08/2019 Details
Ethanol, 2,2'-iminobis-, N-C12-18-alkyl derivs. 276-014-8 71786-60-2
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): oral
14/08/2014
14/08/2014
14/08/2014
28/09/2014
28/09/2014
28/09/2014
 Details
m-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline 275-662-9 71604-74-5
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
15/07/2014
15/07/2014
15/07/2014
15/07/2014
29/08/2014
29/08/2014
29/08/2014
29/08/2014
 Details
Alcohols, C8-10, ethoxylated 615-247-5 71060-57-6
Long-term toxicity to fish
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
22/09/2022
22/09/2022
22/09/2022
07/11/2022
07/11/2022
07/11/2022
 Details
[1α(E),2β]-1-(2,6,6-trimethylcyclohex-3-en-1-yl)but-2-en-1-one 275-156-8 71048-82-3 Reproductive toxicity (pre-natal developmental toxicity) 26/10/2022 12/12/2022 Details
Octasodium 2,2'-[1,4-phenylenebis[imino(6-chloro-1,3,5-triazine-4,2-diyl)imino(1-hydroxy-3,6-disulphonatonaphthalene-2,8-diyl)azo]]bisnaphthalene-1,5-disulphonate 275-108-6 71002-20-5 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant 16/12/2020 01/02/2021 Details
cobalt di(acetate) 200-755-8 71-48-7
Carcinogenicity || Note: testing proposed with Cobalt dichloride (EC 231-589-4) || Note: Testing proposal is based on concern identified by the registrant
Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) || Note: Testing proposal is based on concern identified by the registrant.
21/09/2020
21/09/2020
05/11/2020
05/11/2020
 Details
Cobalt(II) diacetate 200-755-8 71-48-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
02/09/2011
02/09/2011
02/09/2011
17/10/2011
17/10/2011
17/10/2011
 Details
Phenol, 2-methoxy-, reaction products with 2,2-dimethyl-3-methylenebicyclo[2.2.1]heptane, hydrogenated 275-062-7 70955-71-4 Reproductive toxicity (extended one-generation reproductive toxicity study) 26/08/2021 11/10/2021 Details
Formaldehyde, reaction products with m-phenylenediamine, sodium sulfide (Na2S) and sulfur 274-986-8 70892-34-1 Genetic toxicity in vivo 15/01/2024 29/02/2024 Details
O-(2-ethylhexyl) O,O-tert-pentyl peroxycarbonate 274-919-2 70833-40-8
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
03/10/2023
03/10/2023
03/10/2023
17/11/2023
17/11/2023
17/11/2023
 Details
O-(2-ethylhexyl) O,O-tert-pentyl peroxycarbonate 274-919-2 70833-40-8
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
03/03/2014
03/03/2014
17/04/2014
17/04/2014
 Details
Terpenes and terpenoids, turpentine-oil, α-pinene fraction, oligomers. 500-245-8 70750-57-1 Reproductive toxicity (pre-natal developmental toxicity) 04/04/2014 19/05/2014 Details
[[(phosphonomethyl)imino]bis[ethylenenitrilobis(methylene)]]tetrakisphosphonic acid, ammonium salt 274-798-6 70714-66-8 Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Sodium salts of [[(phosphonomethyl)imino]bis[ethane-2,1-diylnitrilobis(methylene)]]tetrakisphosphonic acid (5-7 Na:1) (EC no. 701-216-4) 01/03/2023 17/04/2023 Details
3-(benzothiazol-2-yl)-7-(diethylamino)-2-oxo-2H-1-benzopyran-4-carbonitrile 274-668-9 70546-25-7 Genetic toxicity in vivo 19/10/2020 03/12/2020 Details
2-(2H-benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)phenol 274-570-6 70321-86-7 Bioaccumulation aquatic / sediment 15/07/2014 29/08/2014 Details
Disodium 4-[4-[[5-[(2-bromo-1-oxoallyl)amino]-2-sulphonatophenyl]azo]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-2,5-dichlorobenzenesulphonate 274-499-0 70247-70-0 Genetic toxicity in vivo 18/02/2021 05/04/2021 Details
Disodium [2,4-dihydro-4-[(2-hydroxy-5-nitrophenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-)][3-hydroxy-4-[(2-hydroxy-1-naphthyl)azo]-7-nitronaphthalene-1-sulphonato(3-)]chromate(2-) 274-490-1 70236-60-1 Genetic toxicity in vivo 21/10/2021 07/12/2021 Details
Disodium 6-amino-5-[[4-[(2-bromo-1-oxoallyl)amino]-2-sulphonatophenyl]azo]-4-hydroxynaphthalene-2-sulphonate 274-437-2 70210-40-1 Genetic toxicity in vivo 18/02/2021 05/04/2021 Details
Disodium 5-[[4-[(2-bromo-1-oxoallyl)amino]-2-sulphonatophenyl]azo]-4-hydroxy-6-(methylamino)naphthalene-2-sulphonate 274-436-7 70210-39-8 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 19/10/2020 03/12/2020 Details
Disodium 1-amino-4-[[4-[(2-bromo-1-oxoallyl)amino]-2-sulphonatophenyl]amino]-9,10-dihydro-9,10-dioxoanthracene-2-sulphonate 274-397-6 70209-99-3 Genetic toxicity in vivo 18/03/2021 03/05/2021 Details
Silsesquioxanes, phenyl - 70131-69-0 Long-term toxicity to fish 18/09/2014 03/11/2014 Details
2-(dimethylamino)-2-methylpropan-1-ol 230-279-6 7005-47-2 Reproductive toxicity (pre-natal developmental toxicity) 31/01/2014 17/03/2014 Details
Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) 230-257-6 6990-43-8
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
 Details
Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) 230-257-6 6990-43-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/12/2021
21/12/2021
21/12/2021
04/02/2022
04/02/2022
04/02/2022
 Details
(2-ethyl-2-methyl-1,3-dioxolan-4-yl)methyl prop-2-enoate 807-159-2 69701-99-1 Genetic toxicity in vivo 26/10/2022 12/12/2022 Details
Isopropylcyclohexane 211-792-4 696-29-7
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): inhalation
18/02/2014
18/02/2014
04/04/2014
04/04/2014
 Details
Cyclohex-1,2-ylenediamine 211-776-7 694-83-7 Genetic toxicity in vivo 22/09/2022 07/11/2022 Details
Dioctadecyl 3,3'-thiodipropionate 211-750-5 693-36-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 03/04/2023 22/05/2023 Details
Slags, silicomanganese-manufg. 273-733-9 69012-33-5 Reproductive toxicity (pre-natal developmental toxicity)|| Note: testing proposed with Slags, ferromanganese-manufg. CAS No 69012-28-8 (EC No 273-728-1) 25/10/2017 11/12/2017 Details
Slags, phosphorus-manufg. 273-732-3 69012-32-4
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): inhalation
01/07/2011
01/07/2011
01/07/2011
15/08/2011
15/08/2011
15/08/2011
 Details
Slags, ferromanganese-manufg. 273-728-1 69012-28-8 Reproductive toxicity (pre-natal developmental toxicity) 26/03/2018 11/05/2018 Details
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and pentyl) esters, zinc salts 273-527-9 68988-45-4
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
04/10/2018
04/10/2018
19/11/2018
19/11/2018
 Details
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Bu and pentyl) esters, zinc salts 273-527-9 68988-45-4
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with a read-across member of the ZDDP category(identity of test material not yet decided)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), and Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), and Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6)
21/12/2021
21/12/2021
21/12/2021
04/02/2022
04/02/2022
04/02/2022
 Details
Resin acids and Rosin acids, cobalt salts 273-321-9 68956-82-1 Genetic toxicity in vivo || Note: testing proposed with Cobalt sulphate (EC 233-334-2) 21/01/2021 08/03/2021 Details
Resin acids and Rosin acids, cobalt salts 273-321-9 68956-82-1 Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Neodecanoic acid, cobalt salt (EC no. 248-373-0) 28/11/2022 12/01/2023 Details
Octene, hydroformylation products, low-boiling 273-110-1 68938-03-4 Genetic toxicity in vivo 17/06/2014 01/08/2014 Details
Octene, hydroformylation products, low-boiling 273-110-1 68938-03-4 Reproductive toxicity (pre-natal developmental toxicity) 23/11/2020 07/01/2021 Details
Polysulfides, di-tert-Bu 273-103-3 68937-96-2 Bioaccumulation aquatic / sediment 01/07/2011 15/08/2011 Details
Phenol, isopropylated, phosphate (3:1) 273-066-3 68937-41-7
Bioaccumulation aquatic / sediment
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
29/07/2011
29/07/2011
29/07/2011
29/07/2011
29/07/2011
12/09/2011
12/09/2011
12/09/2011
12/09/2011
12/09/2011
 Details
Phenol, isopropylated, phosphate (3:1) 273-066-3 68937-41-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 26/03/2018 11/05/2018 Details
Phenol, isopropylated, phosphate (3:1) 273-066-3 68937-41-7 Reproductive toxicity (pre-natal developmental toxicity) 30/06/2023 14/08/2023 Details
Benzenamine, N-phenyl-, reaction products with styrene and 2,4,4-trimethylpentene 272-940-1 68921-45-9
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with the smallest aryl- and alkyl-substituted materials
Reproductive toxicity (two-generation reproductive toxicity) || Note: testing proposed with the smallest aryl- and alkyl-substituted materials
14/08/2014
14/08/2014
28/09/2014
28/09/2014
 Details
Fatty acids, tall-oil, reaction products with 2-[(2-aminoethyl)amino]ethanol 272-902-4 68919-76-6 Reproductive toxicity (pre-natal developmental toxicity) 10/03/2017 25/04/2017 Details
Fatty acids, tall-oil, reaction products with 2-[(2-aminoethyl)amino]ethanol 272-902-4 68919-76-6 Sub-chronic toxicity (90 day): oral 16/05/2014 30/06/2014 Details
Gas oils (petroleum), straight-run, high-boiling 272-818-8 68915-97-9 Reproductive toxicity (two-generation reproductive toxicity) 02/09/2011 17/10/2011 Details
Distillates (petroleum), heavy straight-run 272-817-2 68915-96-8 Reproductive toxicity (two-generation reproductive toxicity) 02/09/2011 17/10/2011 Details
Fatty acids, tall-oil, reaction products with formaldehyde and (Z)-N-9-octadecenyl-1,3-propanediamine 272-789-1 68911-83-1 Reproductive toxicity (two-generation reproductive toxicity) || Note: Testing proposal is based on concern identified by the registrant. 15/07/2014 29/08/2014 Details
Hydrocarbons, C12-30, olefin-rich, ethylene polymn. by-product 272-762-4 68911-05-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/08/2011
16/08/2011
25/06/2012
30/09/2011
30/09/2011
09/08/2012
 Details
Quaternary ammonium compounds, bis(hydrogenated tallow alkyl)dimethyl, chlorides, reaction products with polyethylenepolyamines and tall-oil fatty acids, humates hydrochlorides 272-745-1 68910-55-4
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90 day): inhalation
23/01/2015
23/01/2015
23/01/2015
23/01/2015
09/03/2015
09/03/2015
09/03/2015
09/03/2015
 Details
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts 272-723-1 68909-93-3
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with the substance, with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with the substance, with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5)
21/12/2021
21/12/2021
21/12/2021
04/02/2022
04/02/2022
04/02/2022
 Details
Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts 272-723-1 68909-93-3
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Reproductive toxicity (pre-natal developmental toxicity) || Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Sub-chronic toxicity (90-day): oral || Note: substance to be tested is Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0; CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
 Details
Allyl (cyclohexyloxy)acetate 272-657-3 68901-15-5
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
10/08/2018
10/08/2018
24/09/2018
24/09/2018
 Details
Kieselguhr, soda ash flux-calcined 272-489-0 68855-54-9 Sub-chronic toxicity (90 day): inhalation 01/07/2011 15/08/2011 Details
Distillates (petroleum), full-range straight-run middle 272-341-5 68814-87-9 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Distillates (petroleum), heavy straight-run (EC 272-817-2) (CAS 68915-96-8) 21/01/2021 08/03/2021 Details
Distillates (petroleum), full-range straight-run middle 272-341-5 68814-87-9 Reproductive toxicity (two-generation reproductive toxicity) 02/09/2011 17/10/2011 Details
Phosphorodithioic acid, mixed O,O-bis(sec-Bu and 1,3-dimethylbutyl) esters, zinc salts 272-238-5 68784-31-6
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with another ZDDP read-across category member depending on the outcome of the other testing proposals
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1)
21/12/2021
21/12/2021
21/12/2021
04/02/2022
04/02/2022
04/02/2022
 Details
Phosphorodithioic acid, mixed O,O-bis(sec-Bu and 1,3-dimethylbutyl) esters, zinc salts 272-238-5 68784-31-6
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category"
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing Proposed according to a plan for the ZDDP category"
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
 Details
2,5-Furandione, dihydro-, mono-C15-20-alkenyl derivs. 272-221-2 68784-12-3 Reproductive toxicity (two-generation reproductive toxicity) 02/02/2012 19/03/2012 Details
2,5-Furandione, dihydro-, mono-C15-20-alkenyl derivs. 272-221-2 68784-12-3 6.1.2 Long-term toxicity to fish 08/03/2024 22/04/2024 Details
2,5-Furandione, dihydro-, mono-C15-20-alkenyl derivs. 272-221-2 68784-12-3 Reproductive toxicity (pre-natal developmental toxicity) 29/07/2011 12/09/2011 Details
2,5-Furandione, dihydro-, mono-C15-20-alkenyl derivs. 272-221-2 68784-12-3 Reproductive toxicity (pre-natal developmental toxicity) 26/08/2021 11/10/2021 Details
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