Previous Testing Proposals
Previous Testing Proposals
Previous Testing Proposals
This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.
Further instructions
To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.
There are currently no ongoing consultations.
| N,N-dimethyl-alkyl-1-amines, reaction products with alkali hydroxide and chloroacetic acid | 939-682-8 | - |
Long-term toxicity to fish Reproductive toxicity (extended one-generation reproductive toxicity study) |
10/05/2022 10/05/2022 |
27/06/2022 27/06/2022 |
Details | |
| N,N-dimethyl-N'-(2,2,6,6-tetramethylpiperidin-4-yl)propane-1,3-diamine | 278-817-9 | 78014-16-1 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
26/08/2021 26/08/2021 26/08/2021 |
11/10/2021 11/10/2021 11/10/2021 |
Details | |
| N,N-dimethyldecan-1-amide | 238-405-1 | 14433-76-2 | Long-term toxicity to fish | 15/07/2011 | 29/08/2011 | Details | |
| N,N’-di[3-(p-toluene sulfonyl)oxy]phenyl urea | 876-151-9 | 2292123-68-1 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) |
03/04/2023 03/04/2023 |
22/05/2023 22/05/2023 |
Details | |
| N-(1,1-dimethyl-3-oxobutyl)acrylamide | 220-713-2 | 2873-97-4 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
03/03/2014 03/03/2014 |
17/04/2014 17/04/2014 |
Details | |
| N-(2-(4-amino-N-ethyl-m-toluidino)ethyl)methanesulphonamide sesquisulphate | 247-161-5 | 25646-71-3 | Genetic toxicity in vivo | 17/06/2020 | 03/08/2020 | Details | |
| N-(2-ethylhexyl)isononan-1-amide | 810-288-7 | 1700656-13-8 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
26/08/2021 26/08/2021 |
11/10/2021 11/10/2021 |
Details | |
| N-(2-hydroxyethyl)-N-[2-[(1-oxooctyl)amino]ethyl]-β-alanine | 264-761-2 | 64265-45-8 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Amphoacetates C8-C18 (EC 931-291-0) || Note: Testing proposal is based on concern identified by the registrant. | 25/05/2020 | 09/07/2020 | Details | |
| N-(2-hydroxyethyl)-N-[2-[(1-oxooctyl)amino]ethyl]-β-alanine | 264-761-2 | 64265-45-8 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Amphoacetates C8-C18 (EC 931-291-0) || Note: Testing proposal is based on concern identified by the registrant | 21/01/2021 | 08/03/2021 | Details | |
| N-(2-hydroxypropyl)oleamide | 203-828-2 | 111-05-7 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
14/08/2014 14/08/2014 14/08/2014 |
28/09/2014 28/09/2014 28/09/2014 |
Details | |
| N-(2-nitrophenyl)phosphoric triamide | 477-690-9 | - | Long-term toxicity to fish | 18/03/2021 | 03/05/2021 | Details | |
| N-(3-(trimethoxysilyl)propyl)ethylenediamine | 217-164-6 | 1760-24-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
03/03/2014 03/03/2014 |
17/04/2014 17/04/2014 |
Details | |
| N-(3-aminopropyl)-N'-C16-18 (evennumbered), C18 unsaturated alkyl -propane-1,3-diamine | 628-863-4 | 1219458-14-6 | Reproductive toxicity (pre-natal developmental toxicity) | 24/01/2019 | 11/03/2019 | Details | |
| N-(3-aminopropyl)-N'-C16-18 (evennumbered), C18 unsaturated alkyl -propane-1,3-diamine | 628-863-4 | - |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
29/07/2011 29/07/2011 |
12/09/2011 12/09/2011 |
Details | |
| N-(3-aminopropyl)-N`-[3-(C16-18 (evennumbered), C18 unsaturated alkyl amino)propyl]propane-1,3-diamine | 628-862-9 | 1219458-11-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2011 15/07/2011 |
29/08/2011 29/08/2011 |
Details | |
| N-(3-aminopropyl)iminodiethanol | 225-642-0 | 4985-85-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
14/08/2014 14/08/2014 |
28/09/2014 28/09/2014 |
Details | |
| N-(4-amino-9,10-dihydro-3-methoxy-9,10-dioxo-1-anthryl)-4-methylbenzenesulphonamide | 201-369-2 | 81-68-5 | Genetic toxicity in vivo | 20/05/2021 | 05/07/2021 | Details | |
| N-(C16-C18)alkyl(C16-C18)alkane-1-amine | 629-721-4 | - |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
16/06/2011 16/06/2011 16/06/2011 |
01/08/2011 01/08/2011 01/08/2011 |
Details | |
| N-(cyclohexylthio)phthalimide | 241-774-1 | 17796-82-6 |
Bioaccumulation: aquatic / sediment Long-term or reproductive toxicity to birds Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
01/07/2011 01/07/2011 01/07/2011 01/07/2011 17/12/2012 |
15/08/2011 15/08/2011 15/08/2011 15/08/2011 31/01/2013 |
Details | |
| N-(dimethylvinylsilyl)-1,1-dimethyl-1-vinylsilylamine | 231-701-1 | 7691-02-3 |
Reproductive toxicity (pre-natal developmental toxicity)
“|| Note: Testing proposed with hexamethyldisilazane (CAS 999-97-3)” Sub-chronic toxicity (90 day): inhalation
“|| Note: Testing proposed with hexamethyldisilazane (CAS 999-97-3)” |
12/12/2014 12/12/2014 |
26/01/2015 26/01/2015 |
Details | |
| N-[(3-methyl-1H-pyrazol-1-yl)methyl]acetamide; N-[(5-methyl-1H-pyrazol-1-yl)methyl]acetamide | 700-208-8 | - | Sub-chronic toxicity (90-day): oral | 04/10/2018 | 19/11/2018 | Details | |
| N-[2-(piperazin-1-yl)ethyl]C18-unsatured-alkylamide | 629-767-5 | - |
Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2011 15/07/2011 15/07/2011 |
29/08/2011 29/08/2011 29/08/2011 |
Details | |
| N-[2-[(2-bromo-4,6-dinitrophenyl)azo]-5-(diallylamino)-4-methoxyphenyl]acetamide | 257-486-4 | 51868-46-3 | Genetic toxicity in vivo | 26/10/2022 | 12/12/2022 | Details | |
| N-[2-[(2-cyano-4,6-dinitrophenyl)azo]-5-(diethylamino)phenyl]acetamide | 246-058-2 | 24170-60-3 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. | 23/11/2020 | 07/01/2021 | Details | |
| N-[3-(dimethoxymethylsilyl)-2-methylpropyl]ethylenediamine | 245-642-4 | 23410-40-4 |
Reproductive toxicity (pre-natal developmental toxicity) Note: Testing proposal is based on concern identified by the registrant. Testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC 217-164-6) Sub-chronic toxicity (90-day): oral Note: Testing proposal is based on concern identified by the registrant. Testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC 217-164-6) |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
| N-[3-(dimethoxymethylsilyl)propyl]ethylenediamine | 221-336-6 | 3069-29-2 |
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with N-(3-trimethoxysilyl)propyl)ethylenediamine CAS 1760-24-3. Sub-chronic toxicity (90-day): oral
Note: testing proposed with N-(3-trimethoxysilyl)propyl)ethylenediamine CAS 1760-24-3. |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
| N-[3-(dimethylamino)propyl] C 12-C18 alkylamide | 932-121-8 | 1147459-12-8 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
| N-[3-(dimethylamino)propyl]methacrylamide | 226-002-3 | 5205-93-6 | Reproductive toxicity (pre-natal developmental toxicity) | 29/04/2011 | 14/06/2011 | Details | |
| N-[3-(trimethoxysilyl)propyl]butylamine // Note: testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC No. 217-164-6) | 250-437-8 | 31024-56-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
| N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]-2-methyl-prop-2-enamide | 611-915-5 | 59941-98-9 | Genetic toxicity in vivo | 22/04/2021 | 07/06/2021 | Details | |
| N-acetylhexanelactam | 217-565-6 | 1888-91-1 | Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant | 17/06/2020 | 03/08/2020 | Details | |
| N-benzyl-N-C16-18 (even numbered)-alkyl-N-methyl-C16-18 (even numbered)-alkyl-1-aminium chloride | - | - |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
29/07/2011 29/07/2011 |
12/09/2011 12/09/2011 |
Details | |
| N-butyl 4-oxopentanoate | 218-143-4 | 2052-15-5 |
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with Levulinic acid (EC 204-649-2) Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with Levulinic acid (EC 204-649-2) |
23/11/2020 23/11/2020 |
07/01/2021 07/01/2021 |
Details | |
| N-butyl phenyl ether | 214-426-1 | 1126-79-0 | Long-term toxicity to fish | 03/04/2023 | 22/05/2023 | Details | |
| N-butyl-2,2,6,6-tetramethylpiperidin-4-amine | 252-899-6 | 36177-92-1 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): ora |
07/10/2016 07/10/2016 |
21/11/2016 21/11/2016 |
Details | |
| N-butylbenzenesulphonamide | 222-823-6 | 3622-84-2 | Reproductive toxicity (pre-natal developmental toxicity) | 14/02/2011 | 31/03/2011 | Details | |
| N-butylbenzenesulphonamide | 222-823-6 | 3622-84-2 | Reproductive toxicity (pre-natal developmental toxicity) | 29/02/2016 | 14/04/2016 | Details | |
| n-butyltin trichloride | 214-263-6 | 1118-46-3 | Reproductive toxicity (pre-natal developmental toxicity) | 29/04/2011 | 14/06/2011 | Details | |
| N-ethyl-2-pyrrolidone (NEP) | 220-250-6 | 2687-91-4 |
Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day) via the inhalatory route |
26/01/2011 26/01/2011 |
14/03/2011 14/03/2011 |
Details | |
| N-isopropylhydroxylamine | 225-791-1 | 5080-22-8 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 04/04/2014 |
Details | |
| n-methyl-n-[c18-(unsaturated)alkanoyl]glycine | 701-177-3 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) | 21/10/2021 | 07/12/2021 | Details | |
| N-methylaniline | 202-870-9 | 100-61-8 |
Long-term or reproductive toxicity to birds Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): dermal |
01/07/2011 01/07/2011 01/07/2011 01/07/2011 |
15/08/2011 15/08/2011 15/08/2011 15/08/2011 |
Details | |
| N-methylaniline | 202-870-9 | 100-61-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Sub-chronic toxicity (90 day): dermal |
23/04/2018 23/04/2018 |
07/06/2018 07/06/2018 |
Details | |
| N-octadecylstearamide | 236-276-6 | 13276-08-9 |
Long-term toxicity to fish Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (pre-natal developmental toxicity) |
17/04/2015 17/04/2015 17/04/2015 |
04/06/2015 04/06/2015 04/06/2015 |
Details | |
| N-pentan-2-ylidenehydroxylamine | 484-470-6 | 623-40-5 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
20/05/2021 20/05/2021 |
05/07/2021 05/07/2021 |
Details | |
| N-Phenyl-diethanolamine, reaction products with formaldehyde | 942-131-4 | - | Genetic toxicity in vivo | 26/08/2021 | 11/10/2021 | Details | |
| N-Phenyl-diethanolamine, reaction products with formaldehyde | 942-131-4 | - | Reproductive toxicity (pre-natal developmental toxicity) | 21/10/2021 | 07/12/2021 | Details | |
| N-phenyl-N-[(trichloromethyl)thio]benzenesulphonamide | 218-915-0 | 2280-49-1 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
| N-phenylmaleimide | 213-382-0 | 941-69-5 | Genetic toxicity in vivo | 29/04/2011 | 14/06/2011 | Details | |
| N-vinylformamide | 236-102-9 | 13162-05-5 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 01/11/2015 | 16/12/2015 | Details | |