Previous Testing Proposals

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

Showing 1,301 - 1,350 of 2,011 results.

Name	EC Number	CAS Number	Hazard endpoint for which vertebrate testing was proposed	Date of publication to call for available information	Deadline for submitting information
N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isophthalamide	419-710-0	-	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	12/12/2014 12/12/2014 12/12/2014	26/01/2015 26/01/2015 26/01/2015	Details
N,N'-bis(3-aminopropyl)ethylenediamine	234-147-9	10563-26-5	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/03/2021 18/03/2021	03/05/2021 03/05/2021	Details
N,N'-dimethyldiphenylthiuram disulphide	234-196-6	10591-84-1	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	16/08/2019 16/08/2019	30/09/2019 30/09/2019	Details
N,N'-diphenyl-p-phenylenediamine	200-806-4	74-31-7	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant. Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: Testing proposal is based on concern identified by the registrant.	27/01/2020 27/01/2020	12/03/2020 12/03/2020	Details
N,N'-ethane-1,2-diylbis(12-hydroxyoctadecan-1-amide)	204-613-6	123-26-2	Long-term toxicity to fish \|\| Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with: “Octadecanoic acid, 12-hydroxy-, reaction products with ethylenediamine”, CAS 100545-48-0 Sub-chronic toxicity (90 day): oral	30/09/2015 30/09/2015 30/09/2015	16/11/2015 16/11/2015 16/11/2015	Details
N,N'-hexane-1,6-diylbis(hexahydro-2-oxo-1H-azepine-1-carboxamide)	227-563-7	5888-87-9	Genetic toxicity in vivo	18/09/2014	03/11/2014	Details
N,N,2,8-tetramethyl-5,11-dioxa-2,8-diazatridecan-13-amine	695-748-3	65286-55-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	24/02/2020 24/02/2020	09/04/2020 09/04/2020	Details
N,N,N',N'-tetrakis(2,3-epoxypropyl)-m-xylene-α,α'-diamine	264-438-6	63738-22-7	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant.	27/01/2020	12/03/2020	Details
N,N,N',N'-tetramethyl-2,2'-oxybis(ethylamine)	221-220-5	3033-62-3	7.8.1 Toxicity to reproduction 7.8.2 Developmental toxicity / teratogenicity	08/03/2024 08/03/2024	22/04/2024 22/04/2024	Details
N,N,N',N'-tetramethylhexamethylenediamine	203-842-9	111-18-2	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	03/03/2014 03/03/2014	17/04/2014 17/04/2014	Details
N,N,N`,N`,N``-Pentamethyl-N-C16-18 (even numbered) C18 unsat.-alkyl-1,3-propanediammonium chloride	629-716-7	1211950-04-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/07/2011 15/07/2011	29/08/2011 29/08/2011	Details
N,N-bis(2-ethylhexyl)-5-methyl-1H-benzotriazole-1-methylamine, N,N-bis(2-ethylhexyl)-4-methyl-1H-benzotriazole-1-methylamine, 2H-Benzotriazole-2-methanamine, N,N-bis(2-ethylhexyl)-4-methyl-, 2H-Benzotriazole-2-methanamine, N,N-bis(2-ethylhexyl)-5-methyl-, 1H-Benzotriazole-1-methanamine, N,N-bis(2-ethylhexyl)-6-methyl-(Mixture)	939-700-4	-	Sub-chronic toxicity (90-day): oral	21/10/2019	05/12/2019	Details
N,N-bis[3-(dimethylamino)propyl]-N',N'-dimethylpropane-1,3-diamine	251-459-0	33329-35-0	Reproductive toxicity (two-generation reproductive toxicity) Note: testing proposed with structurally-related compound	29/04/2014	13/06/2014	Details
N,N-dimethyl-alkyl-1-amines, reaction products with alkali hydroxide and chloroacetic acid	939-682-8	-	Long-term toxicity to fish Reproductive toxicity (extended one-generation reproductive toxicity study)	10/05/2022 10/05/2022	27/06/2022 27/06/2022	Details
N,N-dimethyl-N'-(2,2,6,6-tetramethylpiperidin-4-yl)propane-1,3-diamine	278-817-9	78014-16-1	Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	26/08/2021 26/08/2021 26/08/2021	11/10/2021 11/10/2021 11/10/2021	Details
N,N-dimethyldecan-1-amide	238-405-1	14433-76-2	Long-term toxicity to fish	15/07/2011	29/08/2011	Details
N,N’-di[3-(p-toluene sulfonyl)oxy]phenyl urea	876-151-9	2292123-68-1	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity)	03/04/2023 03/04/2023	22/05/2023 22/05/2023	Details
N-(1,1-dimethyl-3-oxobutyl)acrylamide	220-713-2	2873-97-4	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	03/03/2014 03/03/2014	17/04/2014 17/04/2014	Details
N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-hydroxy-4-[[2-methoxy-5-[(phenylamino)carbonyl]phenyl]azo]naphthalene-2-carboxamide	235-425-2	12225-06-8	7.5.2 Repeated dose toxicity: inhalation 7.8.2 Developmental toxicity / teratogenicity	08/03/2024 08/03/2024	22/04/2024 22/04/2024	Details
N-(2-(4-amino-N-ethyl-m-toluidino)ethyl)methanesulphonamide sesquisulphate	247-161-5	25646-71-3	Genetic toxicity in vivo	17/06/2020	03/08/2020	Details
N-(2-ethylhexyl)isononan-1-amide	810-288-7	1700656-13-8	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	26/08/2021 26/08/2021	11/10/2021 11/10/2021	Details
N-(2-hydroxyethyl)-N-[2-[(1-oxooctyl)amino]ethyl]-β-alanine	264-761-2	64265-45-8	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Amphoacetates C8-C18 (EC 931-291-0) \|\| Note: Testing proposal is based on concern identified by the registrant.	25/05/2020	09/07/2020	Details
N-(2-hydroxyethyl)-N-[2-[(1-oxooctyl)amino]ethyl]-β-alanine	264-761-2	64265-45-8	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Amphoacetates C8-C18 (EC 931-291-0) \|\| Note: Testing proposal is based on concern identified by the registrant	21/01/2021	08/03/2021	Details
N-(2-hydroxypropyl)oleamide	203-828-2	111-05-7	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	14/08/2014 14/08/2014 14/08/2014	28/09/2014 28/09/2014 28/09/2014	Details
N-(2-nitrophenyl)phosphoric triamide	477-690-9	-	Long-term toxicity to fish	18/03/2021	03/05/2021	Details
N-(3-(trimethoxysilyl)propyl)ethylenediamine	217-164-6	1760-24-3	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	03/03/2014 03/03/2014	17/04/2014 17/04/2014	Details
N-(3-aminopropyl)-N'-C16-18 (evennumbered), C18 unsaturated alkyl -propane-1,3-diamine	628-863-4	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	29/07/2011 29/07/2011	12/09/2011 12/09/2011	Details
N-(3-aminopropyl)-N'-C16-18 (evennumbered), C18 unsaturated alkyl -propane-1,3-diamine	628-863-4	1219458-14-6	Reproductive toxicity (pre-natal developmental toxicity)	24/01/2019	11/03/2019	Details
N-(3-aminopropyl)-N`-[3-(C16-18 (evennumbered), C18 unsaturated alkyl amino)propyl]propane-1,3-diamine	628-862-9	1219458-11-3	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/07/2011 15/07/2011	29/08/2011 29/08/2011	Details
N-(3-aminopropyl)iminodiethanol	225-642-0	4985-85-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	14/08/2014 14/08/2014	28/09/2014 28/09/2014	Details
N-(4-amino-9,10-dihydro-3-methoxy-9,10-dioxo-1-anthryl)-4-methylbenzenesulphonamide	201-369-2	81-68-5	Genetic toxicity in vivo	20/05/2021	05/07/2021	Details
N-(C16-C18)alkyl(C16-C18)alkane-1-amine	629-721-4	-	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral	16/06/2011 16/06/2011 16/06/2011	01/08/2011 01/08/2011 01/08/2011	Details
N-(cyclohexylthio)phthalimide	241-774-1	17796-82-6	Bioaccumulation: aquatic / sediment Long-term or reproductive toxicity to birds Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	01/07/2011 01/07/2011 01/07/2011 01/07/2011 17/12/2012	15/08/2011 15/08/2011 15/08/2011 15/08/2011 31/01/2013	Details
N-(dimethylvinylsilyl)-1,1-dimethyl-1-vinylsilylamine	231-701-1	7691-02-3	Reproductive toxicity (pre-natal developmental toxicity) “\|\| Note: Testing proposed with hexamethyldisilazane (CAS 999-97-3)” Sub-chronic toxicity (90 day): inhalation “\|\| Note: Testing proposed with hexamethyldisilazane (CAS 999-97-3)”	12/12/2014 12/12/2014	26/01/2015 26/01/2015	Details
N-[(3-methyl-1H-pyrazol-1-yl)methyl]acetamide; N-[(5-methyl-1H-pyrazol-1-yl)methyl]acetamide	700-208-8	-	Sub-chronic toxicity (90-day): oral	04/10/2018	19/11/2018	Details
N-[2-(piperazin-1-yl)ethyl]C18-unsatured-alkylamide	629-767-5	-	Bioaccumulation aquatic / sediment Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/07/2011 15/07/2011 15/07/2011	29/08/2011 29/08/2011 29/08/2011	Details
N-[2-[(2-bromo-4,6-dinitrophenyl)azo]-5-(diallylamino)-4-methoxyphenyl]acetamide	257-486-4	51868-46-3	Genetic toxicity in vivo	26/10/2022	12/12/2022	Details
N-[2-[(2-cyano-4,6-dinitrophenyl)azo]-5-(diethylamino)phenyl]acetamide	246-058-2	24170-60-3	Genetic toxicity in vivo \|\| Note: Testing proposal is based on concern identified by the registrant.	23/11/2020	07/01/2021	Details
N-[3-(dimethoxymethylsilyl)-2-methylpropyl]ethylenediamine	245-642-4	23410-40-4	Reproductive toxicity (pre-natal developmental toxicity) Note: Testing proposal is based on concern identified by the registrant. Testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC 217-164-6) Sub-chronic toxicity (90-day): oral Note: Testing proposal is based on concern identified by the registrant. Testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC 217-164-6)	25/06/2015 25/06/2015	10/08/2015 10/08/2015	Details
N-[3-(dimethoxymethylsilyl)propyl]ethylenediamine	221-336-6	3069-29-2	Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with N-(3-trimethoxysilyl)propyl)ethylenediamine CAS 1760-24-3. Sub-chronic toxicity (90-day): oral Note: testing proposed with N-(3-trimethoxysilyl)propyl)ethylenediamine CAS 1760-24-3.	25/06/2015 25/06/2015	10/08/2015 10/08/2015	Details
N-[3-(dimethylamino)propyl] C 12-C18 alkylamide	932-121-8	1147459-12-8	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/09/2014 18/09/2014	03/11/2014 03/11/2014	Details
N-[3-(dimethylamino)propyl]methacrylamide	226-002-3	5205-93-6	Reproductive toxicity (pre-natal developmental toxicity)	29/04/2011	14/06/2011	Details
N-[3-(trimethoxysilyl)propyl]butylamine // Note: testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC No. 217-164-6)	250-437-8	31024-56-3	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/09/2014 18/09/2014	03/11/2014 03/11/2014	Details
N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]-2-methyl-prop-2-enamide	611-915-5	59941-98-9	Genetic toxicity in vivo	22/04/2021	07/06/2021	Details
N-acetylhexanelactam	217-565-6	1888-91-1	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: Testing proposal is based on concern identified by the registrant	17/06/2020	03/08/2020	Details
N-benzyl-N-C16-18 (even numbered)-alkyl-N-methyl-C16-18 (even numbered)-alkyl-1-aminium chloride	-	-	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	29/07/2011 29/07/2011	12/09/2011 12/09/2011	Details
N-butyl 4-oxopentanoate	218-143-4	2052-15-5	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with Levulinic acid (EC 204-649-2) Sub-chronic toxicity (90-day): oral \|\| Note: testing proposed with Levulinic acid (EC 204-649-2)	23/11/2020 23/11/2020	07/01/2021 07/01/2021	Details
N-butyl phenyl ether	214-426-1	1126-79-0	Long-term toxicity to fish	03/04/2023	22/05/2023	Details
N-butyl-2,2,6,6-tetramethylpiperidin-4-amine	252-899-6	36177-92-1	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): ora	07/10/2016 07/10/2016	21/11/2016 21/11/2016	Details
N-butylbenzenesulphonamide	222-823-6	3622-84-2	Reproductive toxicity (pre-natal developmental toxicity)	29/02/2016	14/04/2016	Details

Showing 1,301 - 1,350 of 2,011 results.

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