Previous Testing Proposals

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

Showing 51 - 100 of 1,996 results.

Name	EC Number	CAS Number	Hazard endpoint for which vertebrate testing was proposed	Date of publication to call for available information	Deadline for submitting information
1,1'-methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with butane-1,3-diol, 2,2'-oxydiethanol and propane-1,2-diol	701-173-1	-	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC 202-966-0)	01/04/2022	16/05/2022	Details
1,1'-methylenebis(4-isocyanatobenzene) and oligomeric reaction products of 1,1'-methylenebis(4-isocyanatobenzene) and oxydipropanol and oligomerization reaction products of oxydipropanol	701-041-3	-	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation	16/06/2022 16/06/2022 16/06/2022	01/08/2022 01/08/2022 01/08/2022	Details
1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl )-3-pentanone	436-710-6	756-13-8	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	22/04/2021 22/04/2021	07/06/2021 07/06/2021	Details
1,1,1,3,3,3-hexamethyldisilazane	213-668-5	999-97-3	Reproductive toxicity (extended one-generation reproductive toxicity study)\|\| Note: testing proposed with Hydroxytrimethylsilane (EC no. 213-914-1) Reproductive toxicity (pre-natal developmental toxicity)\|\| Note: testing proposed with Hydroxytrimethylsilane (EC no. 213-914-1)	16/06/2022 16/06/2022	01/08/2022 01/08/2022	Details
1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane	241-867-7	17928-28-8	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: testing proposed with decamethyltetrasiloxane (EC no. 205-491-7, CAS no. 141-62-8)	12/12/2014	26/01/2015	Details
1,1,1,3,5,5,5-heptamethyl-3-octyltrisiloxane	241-881-3	17955-88-3	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	17/06/2020 17/06/2020	03/08/2020 03/08/2020	Details
1,1,1,3,5,5,5-heptamethyltrisiloxane	217-496-1	1873-88-7	Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with Octamethyltrisiloxane, CAS 107-51-7 and 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7 Sub-chronic toxicity (90 day): inhalation Note: testing proposed with 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7.	25/06/2015 25/06/2015	10/08/2015 10/08/2015	Details
1,1,3,3-tetramethyl-1,3-divinyldisiloxane	220-099-6	2627-95-4	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	25/06/2015 25/06/2015	10/08/2015 10/08/2015	Details
1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate	244-894-2	22288-43-3	Reproductive toxicity (pre-natal developmental toxicity)	03/03/2014	17/04/2014	Details
1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate	244-894-2	22288-43-3	Genetic toxicity in vivo	10/05/2022	27/06/2022	Details
1,1,3,3-tetramethylbutyl hydroperoxide	227-369-2	5809-08-5	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	15/07/2014 15/07/2014	29/08/2014 29/08/2014	Details
1,1,3,3-tetramethylbutyl peroxyneodecanoate	257-077-0	51240-95-0	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: Testing proposal is based on concern identified by the registrant	01/09/2017	16/10/2017	Details
1,1,3,3-tetramethylbutyl peroxyneodecanoate	257-077-0	51240-95-0	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	02/06/2014 02/06/2014	17/07/2014 17/07/2014	Details
1,1,3,3-tetramethyldisiloxane	221-906-4	3277-26-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation	29/04/2016 29/04/2016	13/06/2016 13/06/2016	Details
1,1,4,4-tetramethylbutane-1,4-diyl bis(2-ethylperoxyhexanoate)	235-935-5	13052-09-0	Long-term toxicity to fish \|\| Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates	12/12/2014	26/01/2015	Details
1,10-decanediyl diacrylate	235-922-4	13048-34-5	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity)\|\|Note: testing proposed with Esterification products of acrylic acid with reaction products of 2,2-dimethylpropane-1,3-diol and methyloxirane (EC no. 701-440-2) Sub-chronic toxicity (90-day): oral\|\|Note: testing proposed with Esterification products of acrylic acid with reaction products of 2,2-dimethylpropane-1,3-diol and methyloxirane (EC no. 701-440-2)	06/06/2023 06/06/2023 06/06/2023	21/07/2023 21/07/2023 21/07/2023	Details
1,1`-(1,1-dimethyl-3-methylene-1,3-propanediyl)bisbenzene	228-846-8	6362-80-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/02/2014 18/02/2014	04/04/2014 04/04/2014	Details
1,2,3,4-tetrahydronaphthalene	204-340-2	119-64-2	Reproductive toxicity (extended one-generation reproductive toxicity study)	26/03/2018	11/05/2018	Details
1,2,3,4-tetrahydronaphthalene	204-340-2	119-64-2	Reproductive toxicity (two-generation reproductive toxicity)	16/06/2011	01/08/2011	Details
1,2,3,5,6,7-hexahydro-1,1,2,3,3-pentamethyl-4H-inden-4-one	251-649-3	33704-61-9	Reproductive toxicity (pre-natal developmental toxicity)	30/06/2023	14/08/2023	Details
1,2,3,6-tetrahydromethyl-3,6-methanophthalic anhydride	246-644-8	25134-21-8	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	03/11/2023 03/11/2023	18/12/2023 18/12/2023	Details
1,2,4,5,7,8-Hexoxonane, 3,6,9-trimethyl-, 3,6,9-tris(Ethyl and Propyl) derivatives	-	-	Sub-chronic toxicity (90-day): oral	30/06/2016	15/08/2016	Details
1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters	290-754-9	90218-76-1	Sub-chronic toxicity (90-day): oral	29/07/2011	12/09/2011	Details
1,2,4-trimethylbenzene	202-436-9	95-63-6	Reproductive toxicity (pre-natal developmental toxicity)	03/10/2023	17/11/2023	Details
1,2-Benzenedicarboxylic acid, benzyl C7-9-branched and linear alkyl esters	701-339-3	-	Reproductive toxicity (pre-natal developmental toxicity)	25/05/2020	09/07/2020	Details
1,2-Benzenedicarboxylic acid, benzyl C7-9-branched and linear alkyl esters	271-082-5	68515-40-2	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	16/06/2011 16/06/2011	01/08/2011 01/08/2011	Details
1,2-diacetoxybut-3-ene	421-720-5	18085-02-4	Sub-chronic toxicity (90-day): oral	25/11/2021	10/01/2022	Details
1,2-dihydroxybenzene,pyrocatechol	204-427-5	120-80-9	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity)	15/04/2011 15/04/2011	30/05/2011 30/05/2011	Details
1,2-dimethylimidazole	217-101-2	1739-84-0	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	19/10/2020 19/10/2020	03/12/2020 03/12/2020	Details
1,2-dimethylimidazole	217-101-2	1739-84-0	Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity)	10/05/2022 10/05/2022	27/06/2022 27/06/2022	Details
1,2-Ethanediamine, N-(2-aminoethyl)-, reaction products with glycidyl tolyl ether	282-199-6	84144-79-6	Reproductive toxicity (pre-natal developmental toxicity) \|\| Note: Testing proposal is based on concern identified by the registrant.	18/03/2021	03/05/2021	Details
1,3,2-dioxathiolane 2,2-dioxide	600-809-4	1072-53-3	Genetic toxicity in vivo \|\| Note: Link to registration dossier not given as the dossier not yet disseminated \|\| Note: Testing proposal is based on concern identified by the registrant.	24/01/2019	11/03/2019	Details
1,3,3-trimethyl-N-(2-methylpropylidene)-5-[(2-methylpropylidene)amino]cyclohexanemethylamine	259-393-4	54914-37-3	Long-term toxicity to fish	03/10/2023	17/11/2023	Details
1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione	213-834-7	1025-15-6	Reproductive toxicity (pre-natal developmental toxicity)	25/09/2012	12/11/2012	Details
1,3,5-triazine-2,4,6(1H,3H,5H)-trithione, trisodium salt	241-749-5	17766-26-6	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	14/08/2014 14/08/2014	28/09/2014 28/09/2014	Details
1,3,5-tris(2,3-dibromopropyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione	257-913-4	52434-90-9	Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	03/04/2023 03/04/2023 03/04/2023	22/05/2023 22/05/2023 22/05/2023	Details
1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione (TGIC)	219-514-3	2451-62-9	Reproductive toxicity (two-generation reproductive toxicity)	19/11/2010	03/01/2011	Details
1,3,5-tris[3-(trimethoxysilyl)propyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione	247-465-8	26115-70-8	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	03/10/2023 03/10/2023	17/11/2023 17/11/2023	Details
1,3,5-tris[[4-tert-butyl-3-hydroxy-2,6-xylyl]methyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione	254-996-9	40601-76-1	Reproductive toxicity (pre-natal developmental toxicity) with Rat	24/07/2019	09/09/2019	Details
1,3- and 1,4-cyclohexandicarboxyaldehyde	482-020-3	-	Reproductive toxicity (pre-natal developmental toxicity)	15/07/2014	29/08/2014	Details
1,3-Benzenediamine, coupled with diazotized m-phenylenediamine, acetates	282-617-7	84281-74-3	Genetic toxicity in vivo	25/11/2021	10/01/2022	Details
1,3-Benzenedimethanamine, N-(2-phenylethyl) derivs.	445-790-1	-	Sub-chronic toxicity (90 day): inhalation	04/04/2014	19/05/2014	Details
1,3-Butanediol, reaction products with 1,1'-methylenebis[4-isocyanatobenzene], propylene glycol and tripropylene glycol	941-496-7	1689576-89-3	Reproductive toxicity (extended one-generation reproductive toxicity study) \|\| Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC 202-966-0)	01/04/2022	16/05/2022	Details
1,3-diethyldiphenylurea	201-645-2	85-98-3	Sub-chronic toxicity (90-day): oral	03/03/2014	17/04/2014	Details
1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione	258-904-8	53988-10-6	Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt (CAS: 61617-00-3) Reproductive toxicity (two-generation reproductive toxicity) Note: testing proposed with 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt (CAS: 61617-00-3)	15/04/2014 15/04/2014	30/05/2014 30/05/2014	Details
1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt	262-872-0	61617-00-3	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity)	15/04/2014 15/04/2014	30/05/2014 30/05/2014	Details
1,3-diisopropylbenzene	202-773-1	99-62-7	Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral	18/02/2014 18/02/2014	04/04/2014 04/04/2014	Details
1,3-dimethylimidazolidin-2-one	201-304-8	80-73-9	Reproductive toxicity (two-generation reproductive toxicity)	15/04/2014	30/05/2014	Details
1,3-dimethylimidazolidin-2-one	201-304-8	80-73-9	Reproductive toxicity (extended one-generation reproductive toxicity study) Sub-chronic toxicity (90-day): oral	10/05/2022 10/05/2022	27/06/2022 27/06/2022	Details
1,3-dioxepane	208-015-6	505-65-7	Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90 day): inhalation	15/07/2011 15/07/2011 15/07/2011	29/08/2011 29/08/2011 29/08/2011	Details

Showing 51 - 100 of 1,996 results.

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