Registered substances
Registered substances
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The new ECHA CHEM database has been released by ECHA. At first this system will contain only substances and data from REACH registration dossiers. For new and updated REACH registration data please check ECHA CHEM. See for more information on the transition to ECHA CHEM. More
Please be aware that REACH registration data here on the current Dissemination Platform is no longer maintained; it remains frozen as of 19th May 2023.
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Registered Substances Factsheets
Substances which have been registered and can be placed on the EEA market by those companies with a valid registration
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Registrant/Supplier | Address | Country | Registration Status | Name | EC / List no. | CAS no. | Last update year | Details |
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Janssen Pharmaceutica N.V. | Turnhoutseweg 30 2340 Beerse Belgium | Belgium | Active | (2S,3R,4S,5R,6R)-6-(acetoxymethyl)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-2-hydroxytetrahydro-2H-pyran-3,4,5-triyl triacetate | 921-285-6 | 1071929-02-6 | - | View substance registered dossier |
REACHLaw Ltd. | Aleksanterinkatu 19 00100 Helsinki Finland | Finland | Active | (2S,3R,4S,5S,6R)-2-(1,3-dihydroxypropan-2-yloxy)-6-(hydroxymethyl)oxane-3,4,5-triol | 824-773-6 | 22160-26-5 | - | View substance registered dossier |
bitop AG | Carlo-Schmid-Allee 5 44263 Dortmund Germany | Germany | Active | (2S,3R,4S,5S,6R)-2-(1,3-dihydroxypropan-2-yloxy)-6-(hydroxymethyl)oxane-3,4,5-triol | 824-773-6 | 22160-26-5 | 2018; 2021 | View substance registered dossier |
SK BIOTEK IRELAND LIMITED | Watery Lane Swords K67 AY91 Swords Co. Dublin Ireland | Ireland | Active | (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol with 2-butyne-1, 4-diol (1:1) | 619-496-0 | 960404-59-5 | 2014; 2017; 2022 | View substance registered dossier |
AstraZeneca | B 313:5 AZ GlobalSHE- Chem.Reg. 15185 Södertälje Sweden | Sweden | Active | (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol with 2-butyne-1, 4-diol (1:1) | 619-496-0 | 960404-59-5 | - | View substance registered dossier |
FINORGA SAS | 497 route de Givors 38670 CHASSE SUR RHONE France | France | Active | (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol with 2-butyne-1, 4-diol (1:1) | 619-496-0 | 960404-59-5 | 2021 | View substance registered dossier |
Warsaw University of Technology, Faculty of Chemistry, Laboratory of Technological Processes | Noakowskiego 3 00-664 Warszawa Poland | Poland | Cease Manufacture | (2S,3S)-2,3-Bis((4-methoxybenzoyl)oxy)succinic acid | 606-247-6 | 191605-10-4 | 2014 | View substance registered dossier |
MSD International GmbH (Ballydine Branch) | Ballydine - Kilsheelan 0 Clonmel Ireland | Ireland | Active | (2S,3S)-2,3-Bis[(4-methylbenzoyl)oxy]butanedioic acid — methyl {(4S)-8-fluoro-2-[4-(3methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4yl}acetate — ethyl acetate (1:1:1) | 947-432-4 | - | 2018; 2020 | View substance registered dossier |
Excella GmbH & Co. KG | Nuernberger Str. 12 90537 Feucht Germany | Germany | Active | (2S,3S)-2,3-Dihydroxysuccinic acid - (2S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide (1:2) | 954-871-5 | - | - | View substance registered dossier |
Bidachem S.p.A. | S.S. 11 Padana Superiore No. 8 24040 Fornovo San Giovanni BG Italy | Italy | Active | (2S,3S)-2,3-dihydroxysuccinic acid - 2-[(3R)-piperidin-3-yl]-1H-isoindole-1,3(2H)-dione (1:1) | 692-713-4 | 886588-62-1 | 2019 | View substance registered dossier |
Boehringer Ingelheim Pharma GmbH & Co. KG | Binger Strasse 173 55216 Ingelheim am Rhein Germany | Germany | Active | (2S,3S)-2,3-dihydroxysuccinic acid - 2-[(3R)-piperidin-3-yl]-1H-isoindole-1,3(2H)-dione (1:1) | 692-713-4 | 886588-62-1 | 2016; 2019 | View substance registered dossier |
AGC Pharma Chemicals Europe, S.L.U. | Camí de la Pomereda, 13 08380 Malgrat de Mar (Barcelona) Spain | Spain | Active | (2S,3S)-2,3-dihydroxysuccinic acid - 2-[(3R)-piperidin-3-yl]-1H-isoindole-1,3(2H)-dione (1:1) | 692-713-4 | 886588-62-1 | - | View substance registered dossier |
Zoetis Belgium S.A. | Rue Laid Burniat, 1 1348 Louvain-La-Neuve Belgium | Belgium | Active | (2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxy-phenyl)methyl]quinuclidin-3-amine | 831-973-7 | 147116-67-4 | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant French competent national authority. | - | - | Active | (2S,3S)-3-(2-Ethoxyphenoxy)-2-hydroxy-3-phenylpropylammonium methanesulfonate | 425-530-3 | 98769-75-6 | - | View substance registered dossier |
Sterling Pharma Solutions Ltd | Dudley NE23 7QG Cramlington Northumberland United Kingdom | United Kingdom | No longer Valid | (2S,3S)-3-(2-Ethoxyphenoxy)-2-hydroxy-3-phenylpropylammonium methanesulfonate | 425-530-3 | 98769-75-6 | 2021 | View substance registered dossier |
Envigo Consulting Limited | Woolley Road Alconbury PE28 4HS Huntingdon Cambridgeshire United Kingdom | United Kingdom | No longer Valid | (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride | 478-270-8 | - | 2021 | View substance registered dossier |
Janssen Pharmaceutica N.V. | Turnhoutseweg 30 2340 Beerse Belgium | Belgium | Cease Manufacture | (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride | 478-270-8 | - | 2019 | View substance registered dossier |
Envigo Consulting Limited | Woolley Road Alconbury PE28 4HS Huntingdon Cambridgeshire United Kingdom | United Kingdom | No longer Valid | (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride | 478-270-8 | - | 2021 | View substance registered dossier |
OLON Spa | Strada Rivoltana Km 6/7 20053 RODANO Milano Italy | Italy | Active | (2S,3S)-di-tert-butyl 3-ethyl-4-oxopyrrolidine-1,2-dicarboxylate | 942-044-1 | - | 2017 | View substance registered dossier |
Novartis Integrated Services Limited | Ringaskiddy P43 FR63 Ringaskiddy Co. Cork Ireland | Ireland | Active | (2S,3S,3aR,9aS)-3-hydroxy-2-(hydroxymethyl)-7-methyl-2,3,3a,9a-tertryhydro-6H-furo[2’,3’:4,5][1,3]oxazolo [3,2-a]pyrimidin-6-one | 700-330-1 | 433733-92-7 | 2008; 2010; 2019 | View substance registered dossier |
Evonik Operations GmbH | Rellinghauser Straße 1-11 45128 Essen Germany | Germany | Active | (2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-aminium sulfate | 917-270-9 | 29790-50-9 | - | View substance registered dossier |
[Confidential] | - | - | - | (2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-aminium sulfate | 917-270-9 | 29790-50-9 | - | View substance registered dossier |
N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Active | (2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-aminium sulfate | 917-270-9 | 29790-50-9 | 2020 | View substance registered dossier |
Evonik Operations GmbH | Rellinghauser Straße 1-11 45128 Essen Germany | Germany | Active | (2S,3S,4R)-2-aminooctadecane-1,3,4-triol | 439-210-6 | 554-62-1 | - | View substance registered dossier |
[Confidential] | - | - | - | (2S,3S,4R)-2-aminooctadecane-1,3,4-triol | 439-210-6 | 554-62-1 | - | View substance registered dossier |
SCC Scientific Consulting Company GmbH | Am Grenzgraben 11 55545 Bad Kreuznach Germany | Germany | Active | (2S,3S,4R)-2-aminooctadecane-1,3,4-triol | 439-210-6 | 554-62-1 | 2022 | View substance registered dossier |
N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Active | (2S,3S,4R)-2-aminooctadecane-1,3,4-triol | 439-210-6 | 554-62-1 | 2011 | View substance registered dossier |
Gilead Sciences Ireland UC | IDA Business &Technology Park Carrigtohill Cork Cork Ireland | Ireland | Active | (2S,3S,4R)-3-ethyl-4-hydroxy-2-(methoxycarbonyl)pyrrolidinium 4-methylbenzenesulfonate | 813-641-3 | 1799733-43-9 | - | View substance registered dossier |
OLON Spa | Strada Rivoltana Km 6/7 20053 RODANO Milano Italy | Italy | Active | (2S,3S,4R)-methyl 4-((3-(1,1-difluorobut-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)-3-ethylpyrrolidine-2-carboxylate 4-methylbenzenesulfonate | 942-021-6 | 1799733-71-3 | - | View substance registered dossier |
Gilead Sciences Ireland UC | IDA Business &Technology Park Carrigtohill Cork Cork Ireland | Ireland | Active | (2S,3S,4R)-methyl 4-((3-(1,1-difluorobut-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)-3-ethylpyrrolidine-2-carboxylate 4-methylbenzenesulfonate | 942-021-6 | 1799733-71-3 | - | View substance registered dossier |
Esteve Quimica, S.A. | Torre Esteve Passeig de la Zona Franca, 109, 4ª Planta 08038 Barcelona Barcelona Spain | Spain | Active | (2S,3S,4R)-methyl 4-((3-(1,1-difluorobut-3-en-1-yl)-7-methoxyquinoxalin-2-yl)oxy)-3-ethylpyrrolidine-2-carboxylate 4-methylbenzenesulfonate | 942-021-6 | 1799733-71-3 | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Cease Manufacture | (2S,3S,5R)-2-hexyl-3-hydroxy-5-(phenylmethoxy)-Hexadecanoic acid compd. with (S)-α-methylbenzenemethanamine (1:1) | 604-018-5 | 137433-01-3 | 2015 | View substance registered dossier |
Patheon Austria GmbH & Co KG | St. Peter Strasse 25 4020 Linz Austria | Austria | Cease Manufacture | (2S,3S,5R)-2-hexyl-3-hydroxy-5-(phenylmethoxy)-Hexadecanoic acid compd. with (S)-α-methylbenzenemethanamine (1:1) | 604-018-5 | 137433-01-3 | 2020 | View substance registered dossier |
FRESENIUS KABI iPSUM s.r.l. | Via Roma, 108 20060 Cassina de' Pecchi (MI) Italy | Italy | Active | (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide | 618-303-7 | 89786-04-9 | - | View substance registered dossier |
IBI - Istituto Biochimico Italiano Giovanni Lorenzini Spa | Via Fossignano, 2 04011 Aprilia (LT) Italy | Italy | Active | (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide | 618-303-7 | 89786-04-9 | - | View substance registered dossier |
AbbVie Srl | S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy | Italy | Active | (2S,3S,5S)-5-amino-2-(dibenzylamino)-1,6-diphenylhexan-3-ol succinate | 938-481-2 | - | - | View substance registered dossier |
Symrise AG | Mühlenfeldstraße 1 37603 Holzminden Germany | Germany | Active | (2S,4aR)-1,1,5,5-tetramethyl-1,3,4,5,6,7-hexahydro-2H-2,4a-methanonaphthalen-7-ol | 942-036-8 | 645413-57-6 | 2020 | View substance registered dossier |
Corden Pharma Latina S.p.A. | Via Murillo, 7 IT04013 Sermoneta (LT) Lazio Italy | Italy | Cease Manufacture | (2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester | 411-020-8 | - | 2017 | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant Italian competent national authority. | - | - | Active | (2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester | 411-020-8 | - | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. | - | - | Active | (2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester | 411-020-8 | - | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. | - | - | Active | (2S,4R)-1-benzoyl-4-hydroxy-pyrrolydin-2-carboxylic acid methyl ester | 411-020-8 | - | - | View substance registered dossier |
Symrise AG | Mühlenfeldstraße 1 37603 Holzminden Germany | Germany | Active | (2S,4R)-1-hexadecanoyl-4-hydroxy-pyrrolidine-2-carboxylic acid | 944-347-4 | - | - | View substance registered dossier |
Flamma S.p.a. | via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy | Italy | Active | (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid | 604-011-7 | 13726-69-7 | - | View substance registered dossier |
Evonik Operations GmbH | Rellinghauser Straße 1-11 45128 Essen Germany | Germany | Active | (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid | 604-011-7 | 13726-69-7 | 2019; 2022 | View substance registered dossier |
Lundbeck Pharmaceuticals Italy S.p.A | via quarta strada 2 35129 padova Italy | Italy | Active | (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid | 604-011-7 | 13726-69-7 | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2S,4S) 4-Hydroxymethyl-pyrrolidine-1,2-dicarboxylic acid 1-butyl ester 2-methyl ester | 807-618-7 | 1194059-42-1 | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2S,4S)-1-(tert-butoxycarbonyl)-4-(hydroxymethyl)pyrrolidine-2-carboxylic acid | 812-482-7 | 1643468-66-9 | - | View substance registered dossier |
Gilead Sciences Ireland UC | IDA Business &Technology Park Carrigtohill Cork Cork Ireland | Ireland | Active | (2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidine-2-carboxylic acid | 807-416-9 | 1378388-16-9 | - | View substance registered dossier |
Derivados Químicos S.A. | Camino de Pliego, 150 30820 Alcantarilla Murcia Spain | Spain | Active | (2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidine-2-carboxylic acid | 807-416-9 | 1378388-16-9 | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2S,4S)-1-(tert-butoxycarbonyl)-4-(methoxymethyl)pyrrolidine-2-carboxylic acid | 807-416-9 | 1378388-16-9 | - | View substance registered dossier |
AbbVie Srl | S.R. 148 Pontina Km 52 snc 04011 Campoverde di Aprilia (LT) Italy | Italy | Active | (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one | 423-090-7 | 156732-13-7 | 2011; 2018 | View substance registered dossier |
ITELYUM Purification S.P.A. | Via S. Intini n. 2 27015 Landriano (PV) Italy | Italy | Active | (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one | 423-090-7 | 156732-13-7 | 2014 | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. | - | - | Active | (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one | 423-090-7 | 156732-13-7 | - | View substance registered dossier |
POLPHARMA | 19 Pelplińska 83-200 Starogard Gdański Poland | Poland | Cease Manufacture | (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one | 423-090-7 | 156732-13-7 | 2022 | View substance registered dossier |
Curia Italy S.r.l. | VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy | Italy | Active | (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one | 423-090-7 | 156732-13-7 | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant Italian competent national authority. | - | - | Active | (2S,4Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one | 423-090-7 | 156732-13-7 | - | View substance registered dossier |
N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Active | (2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxamide | 812-263-6 | 1416134-49-0 | - | View substance registered dossier |
Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. | - | - | Active | (2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide | 427-200-4 | 76646-91-8 | - | View substance registered dossier |
Pfizer Ireland Pharmaceuticals | n/a P43 X3336 Ringaskiddy Cork Ireland | Ireland | Active | (2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide | 427-200-4 | 76646-91-8 | - | View substance registered dossier |
ACS DOBFAR S.p.A | Viale Addetta 4/12 20067 Tribiano Milano Italy | Italy | Active | (2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide | 427-200-4 | 76646-91-8 | - | View substance registered dossier |
N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Active | (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide | 812-287-7 | 1192651-49-2 | - | View substance registered dossier |
Gilead Sciences Ireland UC | IDA Business &Technology Park Carrigtohill Cork Cork Ireland | Ireland | Active | (2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid | 811-415-9 | 1335316-40-9 | - | View substance registered dossier |
Flamma S.p.a. | via Bedeschi, 22 24040 Chignolo d'Isola Bergamo Italy | Italy | Active | (2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid | 811-415-9 | 1335316-40-9 | 2018 | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one | 255-799-0 | 42399-49-5 | 2018 | View substance registered dossier |
Cambrex Profarmaco Milano Srl | via Curiel, 34 20067 Paullo MI Italy | Italy | Active | (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one | 255-799-0 | 42399-49-5 | - | View substance registered dossier |
LusoChimica S.p.A. | Via Giotto, 9 23871 Lomagna (Lecco) Italy | Italy | Active | (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one | 255-799-0 | 42399-49-5 | - | View substance registered dossier |
Fermion Oy | Koivu-Mankkaan tie 6 A FI-02101 Espoo Finland | Finland | Active | (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one | 255-799-0 | 42399-49-5 | 2018 | View substance registered dossier |
INTEROR | 49, rue d'Ostende F-62100 CALAIS France | France | Active | (2S-cis)-2-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid | 444-810-6 | - | 2014; 2021 | View substance registered dossier |
Zoetis Belgium S.A. | Rue Laid Burniat, 1 1348 Louvain-La-Neuve Belgium | Belgium | Active | (2S-cis)-2-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid | 444-810-6 | - | - | View substance registered dossier |
FINORGA - MOURENX | avenue du lac 64150 MOURENX France | France | Active | (2S-cis)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one | 255-795-9 | 42399-40-6 | - | View substance registered dossier |
Curia France SAS | ZI de Laville 47240 BON-ENCONTRE France | France | Active | (2S-trans)-3-amino-2-methyl-4-oxoazetidine-1-sulphonic acid | 279-393-8 | 80082-65-1 | - | View substance registered dossier |
Curia Italy S.r.l. | VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy | Italy | Active | (2S-trans)-3-amino-2-methyl-4-oxoazetidine-1-sulphonic acid | 279-393-8 | 80082-65-1 | - | View substance registered dossier |
Corden Pharma Latina S.p.A. | Via Murillo, 7 IT04013 Sermoneta (LT) Lazio Italy | Italy | Active | (2S-trans)-3-amino-2-methyl-4-oxoazetidine-1-sulphonic acid | 279-393-8 | 80082-65-1 | - | View substance registered dossier |
CHEMSAFE srl on behalf of AZO INTERNATIONAL CHEMICAL ltd | Via Ribes, 5 10010 Colleretto Giacosa TO Italy | Italy | Active | (2Z)-(5-amino-1,2,4-thiadiazol-3-yl)(ethoxyimino)acetic acid | 616-178-3 | 75028-24-9 | - | View substance registered dossier |
Fine and Performance Chemicals Ltd | Skutterskelfe TS15 0JR Hutton Rudby North Yorkshire United Kingdom | United Kingdom | No longer Valid | (2Z)-(5-amino-1,2,4-thiadiazol-3-yl)(ethoxyimino)acetic acid | 616-178-3 | 75028-24-9 | 2021 | View substance registered dossier |
Chemours Netherlands B.V._3 | Baanhoekweg 22 3313 LA Dordrecht Netherlands | Netherlands | Cease Manufacture | (2Z)-1,1,1,4,4,4-hexafluorobut-2-ene | 700-651-7 | 692-49-9 | 2021 | View substance registered dossier |
Chemours Netherlands B.V. | Baanhoekweg 22 3313 LA Dordrecht Netherlands | Netherlands | Active | (2Z)-1,1,1,4,4,4-hexafluorobut-2-ene | 700-651-7 | 692-49-9 | 2014; 2015; 2019 | View substance registered dossier |
ACS DOBFAR S.p.A | Viale Addetta 4/12 20067 Tribiano Milano Italy | Italy | Active | (2Z)-2-(2-{[(benzyloxy)carbonyl]amino}-1,3-thiazol-4-yl)-5-[(3-methylbut-2-en-1-yl)oxy]-5-oxopent-2-enoic acid | 889-755-2 | 102199-30-4 | - | View substance registered dossier |
ACS DOBFAR S.p.A | Viale Addetta 4/12 20067 Tribiano Milano Italy | Italy | Active | (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[2-methyl-1-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]oxyiminoacetic acid | 616-285-5 | 76028-96-1 | - | View substance registered dossier |
ChemLeader 11 Fine & Performance Chemicals Ltd | Długosza 67 43-188 Orzesze Poland | Poland | Active | (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[2-methyl-1-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]oxyiminoacetic acid | 616-285-5 | 76028-96-1 | - | View substance registered dossier |
Corden Pharma Latina S.p.A. | Via Murillo, 7 IT04013 Sermoneta (LT) Lazio Italy | Italy | Active | (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[2-methyl-1-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]oxyiminoacetic acid | 616-285-5 | 76028-96-1 | - | View substance registered dossier |
F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2Z)-2-chloro-3-(dimethylamino)-N,N-dimethylprop-2-en-1-iminium hexafluorophosphate | 619-785-1 | 249561-98-6 | - | View substance registered dossier |
Bayer AG | Kaiser-Wilhelm-Allee 1 51373 Leverkusen Germany | Germany | Active | (2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal | 813-789-9 | 152873-67-1 | 2020 | View substance registered dossier |
Minakem Dunkerque Production | 224 avenue de la Dordogne Zone d'entreprises du Nord Gracht 59640 DUNKERQUE France | France | Active | (2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal | 813-789-9 | 152873-67-1 | - | View substance registered dossier |
MINAKEM Beuvry Production SAS | 145, Chemin des Lilas 59310 Beuvry-la-Forêt France | France | Active | (2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal | 813-789-9 | 152873-67-1 | - | View substance registered dossier |
PMC ISOCHEM | 32 rue Lavoisier 91710 VERT LE PETIT France | France | Active | (2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal | 813-789-9 | 152873-67-1 | - | View substance registered dossier |
Evotec DS Germany GmbH | Kantstrasse 2 33790 Halle/ Westf. Germany | Germany | Active | (2Z)-2-fluoro-3-(morpholin-4-yl)prop-2-enal | 813-789-9 | 152873-67-1 | - | View substance registered dossier |
FIRMENICH GRASSE SAS OR 2 | Parc Industriel Les Bois de Grasse 06130 Grasse France | France | Active | (2Z)-2-phenylhex-2-enenitrile | 482-160-5 | 130786-09-3 | 2020; 2022 | View substance registered dossier |
FIRMENICH GRASSE SAS OR 1 | Parc Industriel Les Bois de Grasse 06130 Grasse France | France | Active | (2Z)-2-phenylhex-2-enenitrile | 482-160-5 | 130786-09-3 | 2020 | View substance registered dossier |
In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).
ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.
As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).
In the portal results table are presented:
- Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
- Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
- Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
- Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
- Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
- Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
- Link to the full factsheet.
A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.
RELATED INFORMATION
- Registered substances information
- How to determine what will be published (Data Submission Manual 15)
- Understanding REACH Regulation
- Q&A on registered substances
- What is an Infocard? [PDF]
- What is a Registered substance Factsheet? [PDF]
- eChemPortal
- REACH study results download
- REACH Regulation
- ECHA Legal notice
Welcome to the REACH Registered Substance Factsheets
Here you will find details from REACH registrations submitted to ECHA. Registrations under REACH can be submitted either jointly – where a group of legal entities pool their data – or individually. The set of details from each published joint or individual submission is presented as a row in the results table. For each row there is also an ‘eye’ icon leading to the detailed factsheet which contains the entire public dataset, following the IUCLID format.
Note that there can be more than one joint or individual submission for the same substance, thus there can be cases where one substance is covered by many REACH registered substance factsheets.
Note too, that as mentioned in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission.
Finally, please note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).
All substances table
The “All substances” table gives an overview of all the REACH registered substance factsheets on file at ECHA. Since this covers all data ever submitted since the entry into force of the REACH Regulation, there are some substances which are no longer considered registered under REACH in the EU / EEA. These can be for example substances that were registered only in the UK; since Brexit they are no longer registered in the EU / EEA.
The following columns are presented in the “All substances” table:
- Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
- Registration status – indicating the calculated registration status for the whole factsheet: Active – is being manufactured or imported to the EEA by one or more registrants; Cease Manufacture - is no longer being manufactured or imported above 1 tone per calendar year. All registrants of the substance have reported a cease of manufacture or import; or No longer valid - no longer considered registered under REACH and not currently allowed to be manufactured or imported to the EEA, until the substance is registered again.
- Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
- Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
- Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
- Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
- ‘Eye’ icon linking to the full factsheet.
Searching
The search for REACH registered substance factsheets is divided into logically separated blocks of related search filters. Note that the search works so that if you provide filters in different blocks, then the results returned must match the filters in block 1 AND those in block 2 etc. Searches are conducted on all the public data included in all published REACH registrations.
Substance identity
In this block you can search by substance identifiers, under filters for Name, EC / List number, and CAS number. Full or partial identifiers can be used. And under the Name filter you can search by any substance name of any kind from any source. Other numerical identifiers such as Harmonised C&L Index number, or PIC CN code can also optionally be used.
Administrative data
In this block you can search by administrative information relating to REACH registered substance factsheets:
- Registration type – picklist of Full, Intermediate, NONS
- Registration status – picklist of Active, Cease Manufacture, No longer valid
- Submission type – Individual or Joint
- Country in which registered – picklist of current and former EU / EEA member states from which REACH registrations were received
- First published date – the date when a REACH registration factsheet was first published
- Last update date – the last date when any registrant / supplier submission contributing to a given REACH registration factsheet was submitted
- Last update year – the year in which any registrant / supplier last made an update submission included in a given REACH registration factsheet
- Registrant / supplier name – where available and not claimed confidential
- Registration number – where available and not claimed confidential
- Registrant address – where available and not claimed confidential
Substance data
In this block you can search by substance related data from REACH registered substance factsheets:
- Tonnage band – picklist of Tonnage range, Tonnage Confidential, Intermediate use only
- Selected total tonnage band range – available only if Tonnage range is selected, and allows to filter REACH registered substance factsheets within any selected min and max value
- Substance has nanoform – picklist of Yes, No
- PBT assessment outcome – picklist of all possible PBT assessment outcomes
- CSA performed – picklist of Yes, No
Use and exposure
In this block you can search by elements relating to how use and exposure are encoded in REACH registrations.
Under the Life cycle option you can select one or more life cycle stages. The search results returned will include only factsheets containing uses reported under the selected life cycle stages.
Under the Category option there are modal popups for each of the use descriptor categories – Product, Sector of use, Process, Environmental release, and Article categories. In each of these are multi select picklists for all the related descriptor codes. The search results returned will include only factsheets containing uses which include the selected descriptor codes.
Note that the Life cycle and Category options work together, so that if a life cycle stage and Category options are both selected the search results will include factsheets containing specific uses in the selected life cycle stage, and where the use includes the selected descriptor codes.
With the search operator option you can select to refine how the search works. AND refines results and returns only those factsheets where ALL the search filter criteria are met. OR broadens the results and returns factsheets where ANY of the selected search filter criteria are met.
The factsheets
There is always a detailed factsheet per joint or individual submission, and it is generated based primarily on the IUCLID format.
The factsheet header begins with the identity of the substance in question, to which the factsheet is linked. The substance identity should always be aligned with that shown in the related substance Infocard. Note that since the Infocard refreshes daily, whereas the factsheet sometimes refreshes on a slower pace, sometimes the data may be out of alignment. In such cases it will always realign as quickly as possible.
The substance identification is enriched with the data provided in the relevant IUCLID section of the primary submitted dossier – either the joint submission lead, or the single individual submission.
In this section are also provided the type of substance, all other identifiers such as trade names, common names, other names etc, as well as all distinct submitted compositions for the substance.
Next is a page covering administrative type information from the data submitted, including:
Registration details, on the total tonnage band informed to ECHA, the registration type, first published and last updated dates, and whether a chemical safety assessment has been performed.
Registrant / supplier details, giving the identity and status of registrants / suppliers, except where the identity has been claimed confidential.
Registration numbers, giving again the identity and status of registration numbers, except where claimed confidential.
Contact persons responsible for the SDS, giving the non-confidential SDS contacts provided to ECHA.
The remainder of the factsheet faithfully follows the IUCLID structure, covering the C&L and PBT, Manufacture, use, and exposure, Physical and chemical properties, Environmental fate and pathways, Ecotoxicological information, Toxicological information, Analytical methods (if available), Guidance on safe use, Assessment reports, and Reference substances.