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EC number: 836-681-3 | CAS number: 22421-66-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 Jan - 11 Feb 2015
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- Test done per China GLP criterion, not internationally recognized
Test material
- Reference substance name:
- 4-(2-acryloyloxy-ethoxy) benzophenone
- EC Number:
- 836-681-3
- Cas Number:
- 22421-66-5
- Molecular formula:
- C18H16O4
- IUPAC Name:
- 4-(2-acryloyloxy-ethoxy) benzophenone
Constituent 1
- Specific details on test material used for the study:
- Lot number: 30004
Appearance: Waxy, light yellow solid
Purity: 85.7%
Purity test date: 4 March 2015
Expiration date: 17 Jun 2015
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): A fresh sample of activate sludge was collected from the aeration tank of Shenyang Northern Sewage Treatment Plant 1 (conventional treatment plant for domestic waste) one day before the test. Coarse particles were removed by filtration throug a fine sieve and the sample was settled. The settled sludge was washed twice with mineral medium and then resuspended in mineral medium. The sludge was kept aerobic at 20.3 - 22.6 °C until use. On the day of the test, five samples were weighed, dried at 105 °C for 90 minutes, and then reweighed to obtain initial sludge concentration.
- Concentration of sludge: 3992 mg suspended solids/L - Duration of test (contact time):
- 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 45.8 mg/L
- Based on:
- test mat.
- Initial conc.:
- 99.1 mg/L
- Based on:
- ThOD
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Mineral medium per OECD301
- Test temperature: 20 ± 1 °C
- pH: final values, 7.29 - 7.61
- pH adjusted: no
- Suspended solids concentration: 30 mg SS/L
- Continuous darkness: yes
- Other: Inoculated mineral medium was prepared as a single batch and measured into individual BOD bottles. Solid test material was weighed into each bottles as needed.
TEST SYSTEM
- Culturing apparatus: BOD bottles with Lovibond ET999724A BOD-system OxiDirect (automated respirometer) for measurement of oxygen depletion. Bottles kept in incubator.
- Number of culture flasks/concentration: two for inoculum blank and test samples, one each for toxicity and reference substance.
- Details of trap for CO2 and volatile organics if used: KOH solution in seal gasket of bottles.
- Other: Temperature measured hourly in incubator. BOD values measured daily
CONTROL AND BLANK SYSTEM
- Inoculum blank: duplicate
- Abiotic sterile control: none
- Toxicity control: single, containing references substance (92.6 mg ThOD/L) and test substance (94.4 mg ThOD/L)
Reference substance
- Reference substance:
- benzoic acid, sodium salt
- Remarks:
- 91.9 mg ThOD/L
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- 55.5
- Sampling time:
- 20 d
- Remarks on result:
- other: result at end of 10-day window
- Parameter:
- % degradation (O2 consumption)
- Value:
- 69.6
- Sampling time:
- 28 d
- Details on results:
- Biodegradation of the reference substance attained 69.6% by day 3, 95.7% by day 14, and 103.3% by day 28.
Biodegradation of the toxicity control attained 51.6% by day 14, exceeding 25%.
Any other information on results incl. tables
Table 1. 28-Day Biodegradation Results of Inoculum Control (IC) and Test Substance (TS)
Day |
IC-1 DO demand (mgDO/L) |
IC-2 DO demand (mgDO/L) |
TS-1 DO demand (mgDO/L) |
TS-2 DO demand (mgDO/L) |
TS-1 BOD (mg DO/mg test item) |
TS-2 BOD(mg DO/mg test item) |
TS avg BOD(mg DO/mg test item) |
TS-1 %BOD |
TS-2 %BOD |
TS avg %BOD |
1 |
1 |
1 |
3 |
3 |
0.044 |
0.044 |
0.044 |
2.0 |
2.0 |
2.0 |
2 |
1 |
1 |
3 |
3 |
0.044 |
0.044 |
0.044 |
2.0 |
2.0 |
2.0 |
3 |
1 |
1 |
3 |
3 |
0.044 |
0.044 |
0.044 |
2.0 |
2.0 |
2.0 |
4 |
2 |
1 |
3 |
3 |
0.033 |
0.033 |
0.033 |
1.5 |
1.5 |
1.5 |
5 |
2 |
3 |
5 |
5 |
0.055 |
0.055 |
0.055 |
2.5 |
2.5 |
2.5 |
6 |
4 |
5 |
10 |
11 |
0.120 |
0.142 |
0.131 |
5.6 |
6.6 |
6.1 |
7 |
5 |
6 |
12 |
13 |
0.142 |
0.164 |
0.153 |
6.6 |
7.6 |
7.1 |
8 |
3 |
6 |
12 |
13 |
0.164 |
0.185 |
0.175 |
7.6 |
8.6 |
8.1 |
9 |
3 |
6 |
14 |
14 |
0.208 |
0.207 |
0.207 |
9.6 |
9.6 |
9.6 |
10 |
4 |
6 |
16 |
14 |
0.240 |
0.196 |
0.218 |
11.1 |
9.1 |
10.1 |
11 |
4 |
6 |
18 |
16 |
0.284 |
0.240 |
0.262 |
13.1 |
11.1 |
12.1 |
12 |
3 |
6 |
19 |
22 |
0.317 |
0.382 |
0.349 |
14.6 |
17.6 |
16.1 |
13 |
4 |
7 |
23 |
29 |
0.382 |
0.512 |
0.447 |
17.7 |
23.7 |
20.7 |
14 |
5 |
7 |
30 |
33 |
0.524 |
0.589 |
0.557 |
24.2 |
27.2 |
25.7 |
15 |
5 |
7 |
32 |
37 |
0.568 |
0.676 |
0.622 |
26.3 |
31.3 |
28.8 |
16 |
5 |
7 |
35 |
42 |
0.633 |
0.785 |
0.709 |
29.3 |
36.3 |
32.8 |
17 |
6 |
7 |
38 |
48 |
0.688 |
0.905 |
0.797 |
31.8 |
41.9 |
36.8 |
18 |
7 |
8 |
43 |
55 |
0.775 |
1.036 |
0.906 |
35.9 |
47.9 |
41.9 |
19 |
7 |
8 |
50 |
61 |
0.928 |
1.167 |
1.047 |
42.9 |
54.0 |
48.4 |
20 |
7 |
8 |
57 |
68 |
1.081 |
1.319 |
1.200 |
50.0 |
61.0 |
55.5 |
21 |
7 |
9 |
60 |
72 |
1.136 |
1.396 |
1.266 |
52.5 |
64.5 |
58.5 |
22 |
7 |
9 |
62 |
74 |
1.180 |
1.439 |
1.309 |
54.6 |
66.6 |
60.6 |
23 |
8 |
9 |
64 |
76 |
1.212 |
1.472 |
1.342 |
56.1 |
68.1 |
62.1 |
24 |
8 |
9 |
66 |
78 |
1.256 |
1.515 |
1.386 |
58.1 |
70.1 |
64.1 |
25 |
8 |
9 |
68 |
80 |
1.300 |
1.559 |
1.429 |
60.1 |
72.1 |
66.1 |
26 |
9 |
11 |
70 |
82 |
1.311 |
1.570 |
1.440 |
60.6 |
72.6 |
66.6 |
27 |
9 |
11 |
72 |
84 |
1.354 |
1.614 |
1.484 |
62.6 |
74.6 |
68.6 |
28 |
9 |
11 |
73 |
85 |
1.376 |
1.635 |
1.506 |
63.6 |
75.6 |
69.6 |
The difference of extremes of replicate values of the removal of the test item at the end of the test was 12%.
Table 2. 28-Day Biodegradation Results of Toxicity Control (TC) and Procedural Control (PC)
Day |
TC DO demand (mgDO/L) |
PC DO demand (mgDO/L) |
TC BOD (mgDO/mg test item) |
PC BOD (mgDO/mg test item) |
TC %BOD |
PC %BOD |
1 |
40 |
46 |
0.393 |
0.815 |
20.5 |
48.9 |
2 |
54 |
56 |
0.534 |
0.996 |
27.9 |
59.8 |
3 |
68 |
65 |
0.675 |
1.159 |
35.3 |
69.6 |
4 |
76 |
70 |
0.751 |
1.241 |
39.2 |
74.5 |
5 |
85 |
78 |
0.831 |
1.368 |
43.4 |
82.1 |
6 |
91 |
84 |
0.871 |
1.440 |
45.5 |
86.5 |
7 |
93 |
87 |
0.882 |
1.476 |
46.1 |
88.6 |
8 |
95 |
88 |
0.912 |
1.513 |
47.6 |
90.8 |
9 |
96 |
87 |
0.922 |
1.494 |
48.2 |
89.7 |
10 |
98 |
89 |
0.937 |
1.522 |
49.0 |
91.4 |
11 |
100 |
91 |
0.957 |
1.558 |
50.0 |
93.5 |
12 |
101 |
92 |
0.972 |
1.585 |
50.8 |
95.2 |
13 |
103 |
93 |
0.982 |
1.585 |
51.3 |
95.2 |
14 |
104 |
94 |
0.987 |
1.594 |
51.6 |
95.7 |
15 |
106 |
95 |
1.007 |
1.612 |
52.6 |
96.8 |
16 |
108 |
97 |
1.028 |
1.648 |
53.7 |
99.0 |
17 |
110 |
97 |
1.043 |
1.639 |
54.5 |
98.4 |
18 |
112 |
98 |
1.053 |
1.639 |
55.0 |
98.4 |
19 |
115 |
99 |
1.083 |
1.657 |
56.6 |
99.5 |
20 |
118 |
100 |
1.113 |
1.676 |
58.2 |
100.6 |
21 |
123 |
101 |
1.159 |
1.685 |
60.5 |
101.1 |
22 |
129 |
101 |
1.219 |
1.685 |
63.7 |
101.1 |
23 |
137 |
102 |
1.295 |
1.694 |
67.6 |
101.7 |
24 |
145 |
101 |
1.375 |
1.676 |
71.9 |
100.6 |
25 |
149 |
102 |
1.415 |
1.694 |
74.0 |
101.7 |
26 |
153 |
104 |
1.441 |
1.703 |
75.3 |
102.2 |
27 |
155 |
104 |
1.461 |
1.703 |
76.3 |
102.2 |
28 |
157 |
105 |
1.481 |
1.721 |
77.4 |
103.3 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- oxygen uptake of the inoculum blank <60 mg/l in 28 days (10 mg/L), degradation of the reference substance reached pass level by day 14 (day 3), extremes of replicate BODs at the end of the test is less than 20% (12%).
- Interpretation of results:
- readily biodegradable, but failing 10-day window
- Conclusions:
- 69.6% BOD/ThOD in 28 days, 10 day window exceeded (OECD301F)
- Executive summary:
Aryloxyacrylate biodegradation was assessed according to guideline OECD 301F (manometric respirometry). Duplicate samples and a single toxicity control were tested with sodium benzoate as reference substance. The substance attained 10.1% average degradation on day 10 and exceeded 60% average degradation on day 22. The toxicity control result (52% BOD on day 14) showed that aryloxyacrylate is not inhibitory to biodegradation. Aryloxyacrylate is readily biodegradable but fails the 10-day window.
The test was conducted under an international test guideline and was compliant with local GLP criteria. While the study is otherwise of acceptable quality, local GHS is not accepted internationally. Therefore, the study was deemed reliable with restrictions and suitable for use in Risk Assessment, Classification & Labelling, and PBT Analysis.
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