ethyl 6-(4-aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxylate

Guidance on Safe Use

First-aid measures

Eye contact Rinse immediately with plenty of water for at least 15 minutes. Keep eye wide open while

rinsing. Obtain medical attention.

Skin contact Take off contaminated clothing and shoes immediately. Wash off immediately with plenty

of water for at least 15 minutes. Obtain medical attention. Discard contaminated clothing

or wash before re-use.

Inhalation Move to fresh air. Oxygen or artificial respiration if needed. Obtain medical attention.

Ingestion Do NOT induce vomiting. Consult a physician if necessary. Never give anything by

mouth to an unconscious person.

Notes to Physician Material not fully tested. Refer to Section 11.

Medical Surveillance Employees who are pregnant, are breast-feeding, or who are concerned with other

reproductive issues should be encouraged to consult with the occupational health physician

monitoring worker's health.

Fire-fighting measures

Flammable Properties Not available

Extinguishing Media Suitable extinguishing media: Dry chemical, Water spray, Foam

Unsuitable extinguishing media: Do NOT use water jet.

Protection of

Firefighters

Specific hazards: Not available

Protective equipment: Use personal protective equipment. In the event of fire, wear selfcontained

breathing apparatus.

Hazardous Combustion Products: carbon oxides (COx), nitrogen oxides (NOx)

Other information Decontaminate protective clothing and equipment before reuse.

Accidental release measures

Personal precautions Refer to protective measures listed in sections 7 and 8. Use personal protective equipment.

Examples include tightly fitting safety goggles, disposable lab coat of low permeability

with cuffs, double gloves and shoe covers. Wear respiratory protection. Depending on the

nature of the spill (quantity and extent of spill) additional protective clothing and

equipment such as a self-contained breathing apparatus may be needed.

Environmental

precautions

Prevent release to drains and waterways. Prevent release to the environment.

Containment Methods Wet down any dust to prevent generation of aerosols, if appropriate. Cover with suitable

material.

Cleanup Methods Spill prevention procedures and a spill response procedure should be implemented.

Contain and collect spillage and place in container for disposal according to local

regulations (see Section 13). Clean spill area with a deactivating solution (if available)

followed by detergent and water after spill pick-up. Handle waste materials, including

gloves, protective clothing, contaminated spill cleanup material, etc., as appropriate for

chemically and pharmacologically similar materials.

Handling and storage

Handling Precautions Highly potent material. Avoid exposure - obtain special instructions before use. Avoid

formation of dust and aerosols. Keep away from heat and sources of ignition. Prevent

release to drains and waterways.

Container

Requirements

Store in closed container under nitrogen.

Storage Conditions Store at room temperature in the original container. 15 - 30°C Keep away from heat,

sparks and flames. Protect against light. Avoid moisture.

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

Engineering

Controls and

Ventilation

Use process enclosures, containment technology, or other engineering controls to keep

airborne levels below recommended exposure limit. When handling quantities up to 3

milligrams, a standard laboratory with general laboratory dilution ventilation (e.g. 6-12 air

changes per hour) is appropriate. When handling quantities up to 1 kilogram, work in either a

standard laboratory (<500 g) or designated laboratory (500 g to <1 kg) using a fume hood,

biological safety cabinet(Class II, Type A2 with thimble connection, B1, or B2)or approved

vented enclosure. HEPA filtered exhaust preferred for fume hoods containing particularly

"dusty" operations. Quantities exceeding 1 kilogram should be handled in a designated

laboratory or containment facility using appropriate containment technology. A laminar

flow/powder containment booth or appropriate isolation technology should be considered for

handling more than 1 kilogram of active compound. HEPA filtered exhaust preferred. For

manufacturing and pilot plant operations, barrier/containment technology and direct coupling

(totally enclosed processes that create a barrier between the equipment and the room) with use

of double or split butterfly valves, hybrid unidirectional airflow/local exhaust ventilation

solutions (e.g. powder containment booth) should be used. Glove bags, isolator/glove box

systems are optional. HEPA filtration of exhaust from dry product handling areas is required.

Respiratory

protection

Use and selection of respiratory protection is based upon engineering controls in use and

potential for aerosol generation. When engineering controls are not sufficient control

exposure, wear an approved respirator with NIOSH Class 100 or high efficiency particulate

(HEPA) filters or cartridges (EN 140/EN 136) when exposures are up to 10 times the exposure

control guideline. Wear a loose-fitting (Tyvek or helmet type) HEPA powered-air purifying

respirator (PAPR) (EN 12941) when exposures are 10-25 times the exposure control

guideline. Wear a full facepiece negative pressure respirator with Class 100 or HEPA filters

(EN 136) when exposures are 25-50 times the exposure control guideline. Wear a tightfitting,

full facepiece HEPA PAPR (EN 12942) when exposures are 50-100 times the exposure

control guideline. Wear a hood-shroud HEPA PAPR (EN 12941) or full facepiece supplied

air respirator (EN 139) operated in a pressure demand or other positive pressure mode when

exposures are 100-1000 times the exposure control guideline.

Eye protection Safety glasses with side-shields are recommended (EN 166). Face shields or chemical safety

goggles (EN 166) may be required if splash potential exists or if corrosive materials are

present. Note: Choice of eye protection may be influenced by the type of respirator which is

selected.

Hand protection Wear gloves at all times when handling containers, including when unpacking, inspecting or

transporting within a facility. Impervious gloves are recommended. (EN 420, EN 374).

Double gloving for all manufacturing personnel potentially in direct contact with the

compound should be considered. If material is handled in solution, the solvent should also be

considered when selecting protective clothing material.

Skin and body

protection

Wear a laboratory coat (EN 340) when handling quantities up to 500 grams. For quantities up

to 1 kilogram, wear disposable laboratory coat (EN 340) or coverall of low permeability (EN

1149-1) . For quantities over 1 kilogram and manufacturing operations, wear disposable

coverall of low permeability (EN 1149-1) and disposable shoe covers.

Hygiene Wash hands and face before breaks and immediately after handling the product.

Environmental

exposure controls

Prevent release to drains and waterways.

Stability and reactivity

Stability

Chemical

Stability

Stable at room temperature.

Conditions to

avoid

Not available

Materials to

avoid

ketones

Hazardous

decomposition

products

Hazardous decomposition products formed under fire conditions.: carbon oxides (COx),

nitrogen oxides (NOx)

Hazardous

reactions

None known.

Sensitivity to static discharge/Dust exp.

Summary

Statements

Although material has not been specifically tested, fine dust suspended in air in sufficient

concentration and in the presence of an ignition source may pose a potential explosion hazard.

Provide appropriate bonding and grounding protection to control static charge. Powder

handling equipment such as dust collectors, dryers, and mills may require additional protective

measures (e.g. explosion venting, inerting, etc.).

Disposal considerations

Advice On Disposal And Packaging Disposal should be in accordance with applicable regional, national and local

laws and regulations. Local regulations may be more stringent than regional

or national requirements.

Other information This information presented only applies to the material as supplied.

Disposal by incineration is recommended.