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EC number: 947-924-9 | CAS number: -
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-12-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Key result
- Medium:
- n-octanol
- Solubility:
- 178.4 mg/L
- Temp.:
- 20 °C
- Test substance stable:
- not determined
- Conclusions:
- The solubility in n-octanol was determined to be 178.4 at 20 °C.
- Executive summary:
A study was conduted to determine the solubility of the test item in 1-octanol. Therefore 9 flasks were prepared containing 1 mg – 1 g of the test item and 20 mL of 1-octanol and were shaken for 24, 48 and 72 h respectively. After 24 h the test item concentration in 3 flasks were determine using a HPLC-ELSD method. The solubility in 1- octanol of the test item was determined to be 178.4 mg/L at 20 °C
Reference
The Table below shows the weighted samples (x mg/20 ml 1-Octanol), the sum of peak areas of the signals, the resulting 1 -Octanol solubility of the test item as well as the average and the standard deviation:
Flask |
Shaking Duration (h) |
Weighted sample in mg/20 mL |
Sum of peak areas of the signals |
1 -Octanol solubility of test item mg/L |
Average /day mg/L |
Average mg/L |
Standard deviation mg/L |
OCT-1 |
24 |
51.8 |
10261084 |
164.4 |
164.9 |
178.4 |
11 |
OCT-2 |
24 |
53.2 |
9354020 |
164.3 |
|||
OCT-3 |
24 |
54.8 |
9534447 |
166 |
|||
OCT-4 |
48 |
53.6 |
12098798 |
188.9 |
185.9 |
||
OCT-5 |
48 |
53.5 |
12525646 |
192.4 |
|||
OCT-6 |
48 |
52.8 |
10671628 |
176.5 |
|||
OCT-7 |
72 |
51 |
11363913 |
182.6 |
184.3 |
||
OCT-8 |
72 |
51.5 |
11711363 |
185.6 |
|||
OCT-9 |
72 |
54.2 |
11601139 |
184.6 |
Description of key information
The solubility in 1- octanol of the test item was determined to be 178.4 mg/L at 20 °C
Key value for chemical safety assessment
- Solubility in organic solvents at 20°C:
- 178.4 mg/L
Additional information
A study was conducted to determine the solubility of the test item in 1-octanol. Therefore 9 flasks were prepared containing 1 mg – 1 g of the test item and 20 mL of 1-octanol and were shaken for 24, 48 and 72 h respectively. After 24 h the test item concentration in 3 flasks were determine using a HPLC-ELSD method. The solubility in 1- octanol of the test item was determined to be 178.4 mg/L at 20 °C
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