Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD Guideline 105
- Deviations:
- yes
- Remarks:
- OECD Guideline 105 is a water solubility test. To determine the solubility of the substance in octanol, a similar protocol was used using octanol as the solvent.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Mitsubishi-Chemical Food Corporation;
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: in refrigerator
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final preparation of a solid: pulverized - Key result
- Medium:
- n-octanol
- Solubility:
- >= 1 000 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: miscible in octanol
- Test substance stable:
- not determined
- Details on results:
- The pre-test solubility was incorrect as the test substance dissolution kinetics were slower than foreseen.
No precipitation was seen even after 10 g of test substance had been added. The solution became very viscous and could no longer be stirred. - Conclusions:
- The test substance is completely miscible in octanol.
- Executive summary:
The solubility of the test substance was determined in a study performed similarly to an OECD Guideline 105 water solublity study, but octanol was used as the solvent. Up to 10 g of test substance was added to 10 mL of water. The liquid became very viscous, but no precipitate was observed. The solubility of the test substance in octanol is at least 1 kg/L octanol. The test substance is completely miscible in octanol at 20 degrees C.
Reference
Description of key information
The solubility of the test substance was determined in a study performed similarly to an OECD Guideline 105 water solublity study, but octanol was used as the solvent. Up to 10 g of test substance was added to 10 mL of water. The liquid became very viscous, but no precipitate was observed. The solubility of the test substance in octanol is at least 1 kg/L octanol. The test substance is completely miscible in octanol at 20 degrees C.
Key value for chemical safety assessment
- Solubility in organic solvents at 20°C:
- 1 000 g/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
