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EC number: 824-341-7 | CAS number: 357338-13-7
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 Jan 2019 - 05 Mar 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
Test material
- Reference substance name:
- (S)-2-(5-Oxo-3-propyl-1,2-dihydropyrrol-1-yl) butyramide
- Cas Number:
- 357338-13-7
- Molecular formula:
- C11H18N2O2
- IUPAC Name:
- (S)-2-(5-Oxo-3-propyl-1,2-dihydropyrrol-1-yl) butyramide
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Appearance: Off-white powder
- Storage condition of test material: In refrigerator protected from light
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- 223 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 335 g/L
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- >= 7.2 - <= 7.4
- Remarks on result:
- other: result is the mean of 48 and 72 h measurements.
- Details on results:
- The result of the preliminary test after 26 hours of stirring is comparable to the result obtained in the main study after stirring for 24 hours. Saturation factor in the main study is less than 2. This however is accepted since mixtures at higher nominal concentrations than used in the main study cannot be stirred anymore.
- No test item was detected in the pretreated sample from the blank water mixture.
- The 24-hour measurement was considerably lower than the 48- and 72- hour measurements - concentration analysed after 24, 48 and 72 hours of stirring: 176 g/L, 240 g/L and 2073 g/L, resp.
- Maximum difference was > 15% thus the water solubility of the test item was given as the mean value of the 48- and 72-hour measurements.
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the substance at 20°C was determined to be 223 g/L (flask method).
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