Registration Dossier
Registration Dossier
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EC number: 701-227-4 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro, cadmium telluride did not induce point mutations in S. typhimurium tester strains TA98, TA100, TA1535, TA1537, TA1538 and the E. coli strain WP2urvrA, both with and without metabolic activation. Cadmium telluride was negative in a chromosome aberration study with V79 hamster cells and in a gene mutation test using mouse lymphoma L5178Y cells.
Based on the negative results from the Ames test and Mouse lymphoma test, cadmium telluride is considered to be non-mutagenic and based on the chromosome aberration test, it is considered as non-clastogenic. Overall, cadmium telluride is considered to be non-genotoxic.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
For assessing the mutagenicity of CdZnS, reference has been made to toxicity data obtained by standard mutagenicity testing on CdTe, a sparingly soluble Cd-compound.
Bio-elution tests done in different artificial fluids, showed that the solubility of Cd in CdZnS is much lower than the solubility of Cd from CdTe. Substances with higher solubility are expected to penetrate more easily into the organism and therefore since cadmium telluride is not-genotoxic, it can be conluded that CdZnS is not genotoxic and no classification for mutagenicity is required.
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