Registration Dossier
Registration Dossier
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EC number: 701-197-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
General consideration
The scientifically accepted calculation tool EPIWIN (by US-EPA) was used to determine the phototransformation behaviour in air, hydrolysis, the biodegradation potential in water, aquatic bioaccumulation, soil adsorption and the substance specific Henry´s Law Constant (HLC). No GLP criteria are applicable for the usage of these tools, but due to the fact that they are scientifically accepted calculation methods the estimations performed are reliable with restrictions (Klimisch 2) and can be used for the chemical safety assessment. The corresponding software programs of EPIWIN were often used in two variations of the test substance: with and without chlorine in the main component.
Stability
The gas-phase reaction constants and half-lives in the atmosphere predicted by AOPWIN v1.92 differ only a little depending on chlorine and its appearance (Chemservice S.A., 2012). With chlorine the overall OH rate constant is 57.52E-12 cm³/molecules-sec with a half-life of 2.23 hours, whereas without chlorine the rate constant is predicted as 54.44E-12 cm³/molecules-sec with a half-life of 2.36 hours, assuming a 12 h day with an OH rate of 1.5E6 OH/cm³ and 25 °C.
Epoxides were detected as hydrolysable substance class by HYDROWIN v2.00 with half-lives of ~ 44 years and ~ 29 years for the main component with and without chlorine, respectively, at 25 °C and pH 7 (Chemservice S.A., 2012).
Biodegradation
An experiment in order to investigate the ready biodegradability of the test substance was performed according to OECD Guideline 301F, EU Method C.4 -D and US EPA Draft OPPTS 835.3110 over a prolonged time duration of 55 days (Eisner, 2013). At Exposure Day 28 and at test end after 55 days, the mean biodegradation of 1,2,3-Propanetriol, glycidyl ethers amounted to 13 % and 24 % of the COD, respectively. The pass level for ready biodegradability was not reached. In conclusion the test substance is not readily biodegradable.
The aquatic bioconcentration factor (BCF) was predicted as 3.16 L/kg wet-wt by the regression-based estimate of BCFBAF v3.01 (Chemservice GmbH, 2011), indicating that bioaccumulation in aquatic biota can be ruled out.
Transport and distribution
A low potential for soil adsorption is predicted by KOCWIN v2.00, since the organic-normalized sorption coefficient (Koc) was predicted as 10 L/kg (Chemservice GmbH, 2011).
Based on the Bond Method of HENRYWIN v3.20 the Henry´s Law Constant is predicted as 7.11E-12 Pa*m³/mol, whereas the Group Method estimation resulted in a Henry´s Law Constant of 4.72E-17 Pa*m³/mol for the main component with chlorine (Chemservice S.A., 2012). The Henry´s Law Constants for the component without chlorine are predicted as 2.15E-9 Pa*m³/mol and 2.37E-14 Pa*m³/mol concerning both methods, respectively.
Neither monitoring data nor field studies are available for the test substance.
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