Registration Dossier
Registration Dossier
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EC number: 701-177-3 | CAS number: -
Carcinogenicity
Administrative data
Description of key information
Study not required as triggers in Annex X, Section 8.9.1, Column 2, of Regulation (EC) No. 1907/2006 (REACH) are not met.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Additional information
According to Regulation (EC) No. 1907/2006 (REACH), Annex X, Section 8.9.1, Column 2, testing of carcinogenicity is not indicated, as several studies investigating the genetic toxicity of N-methyl-N-(C18-(unsaturated)alkanoyl)glycine (EC No. 701-177-3) in-vitro have shown that the substance is not genotoxic. Moreover, the subchronic repeated dose toxicity test via the oral route conducted revealed no substance-related adverse effects indicative for carcinogenicity such as hyperplasia or pre-neoplastic changes (e. g. metaplasia).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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