Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 945-544-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD₅₀ > 5000 mg/kg bw, similar to OECD Guideline 423 (Dow Corning Corporation, 1980c).
Acute dermal toxicity: LD₅₀ > 2000 mg/kg bw, similar to OECD Guideline 402 (Dow Corning Corporation, 1980d).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Oral
Reaction Mass of bis(trimethoxysilylpropyl)methylphosphonate and (trimethoxysilylpropyl)methylmethylphosphonate has been tested in an acute oral toxicity study conducted according to a guideline equivalent to OECD TG 401. The undiluted test substance was administered by gavage to 5 male and 5 female rats at 5000 mg/kg. All rats exhibited weakness and drowsiness for several hours after the treatment. One female rat died after one hour but the remaining animals appeared normal at 48 hours after treatment, and all remaining animals survived the 14 day observation period. Under the test conditions, the test substance has a very low acute oral toxicity. The LD50 was determined to be greater than 5000 mg/kg bw (Dow Corning Corporation 1980c).
Dermal
In an acute dermal toxicity study Reaction Mass of bis(trimethoxysilylpropyl)methylphosphonate and (trimethoxysilylpropyl)methylmethylphosphonate was tested in a limit test conducted according to a test guideline equivalent to OECD TG 402. Single dermal administration at 2000 mg/kg to five male and five female rabbits did not result in mortality. The acute dermal LD50 was therefore established to be greater than 2000 mg/kg in this study (Dow Corning Corporation 1980d).
Justification for classification or non-classification
Based on the available information for Reaction Mass of bis(trimethoxysilylpropyl)methylphosphonate and (trimethoxysilylpropyl)methylmethylphosphonate, the substance does not require classification for acute toxicity according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
