Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 813-358-5 | CAS number: 4886-26-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
three Guideline studies according to OECD in vitro Testing Scheme are available.
However the results of these studies are of limited use for hazard assessment as the substance is unstable in the chosen solvent and degrades fast. Among the degradation products, Aniline is liberated which is a known skin sensitizer. However it is not conclusive whether the observed positive results are caused solely by Aniline or by other not further characterised degradation products obtained under the test conditions. The usability of the results of these tests is therefore not given.
one Guideline study on in vivo testing available and used for assessment.
no studies on respiratory sensitisation available.
Assessment can be done based on molecular structural features.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
initially two in vitro/in chemico studies were performed in accordance with the testing scheme set up based on OECD AOP on skin sensitisation.
One study result was negative for skin sensitizing properties whereas the second study result was positive.
Consecutively, a third in vitro study was performed and a positive result was obtained.
After careful assessment of the in vitro study methods and performing stability tests with the substance in the used solvent (Dimethylsulfoxide, DMSO)
it was concluded that use of the solvent DMSO in the two positive in vitro tests decreased the stability of the substance and degradation occured. However only DMSO can be used as vehicle in the used in vitro cell assays. Among the degradation products Aniline was present, which is a well known skin sensitiser.
To further investigate the potential of the substance for skin sensitisation, an in vivo Local Lymph node Assay was performed as the in vitro assays could not descriminate between the effects of the substance itself or its degradation products, formed under the test conditions.
For the performance of the LLNA a solvent was chosen, which does not decrease the stability of the substance.
The results of the LLNA indicate not potential for skin sensitisation for the substance itself.
The foreseen use conditions of the substance (i.e. choice of solvent in solvent based processes) are not expected to decrease the stability of the substance
and degradation is not expected.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
According to "Guidance on Information Requirements and Chemical Safety Assessment Chapter R.7a: Endpoint specific guidance, European Chemicals Agency, 2017",
Figure R.7.3–4 Assessment strategy for respiratory sensitisation data, the assessment of the substance concludes to "The substance is not a respiratory sensitiser"
Justification for classification or non-classification
The available information is conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.