Registration Dossier
Registration Dossier
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EC number: 813-266-5 | CAS number: 45101-66-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
6-chlorohexyl methacrylate is expected to be readily absorbed by all routes and rapidly hydrolyzed in the body based on its similarity with short chain alkyl methacrylates.
Key value for chemical safety assessment
Additional information
No experimental data is available regarding the toxicokinetics, metabolism and distribution of 6-chlorohexyl methacrylate (6-CHMA) but a similar behaviour to short chain alkyl methacrylates and in particular with 2-ethylhexyl methacrylate is expected (see document "Read -across hypothesis and justification" in section 13 of this IUCLID dossier).
In SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) some experimental data are reported regarding the toxicokinetics and metabolism of short chain alkyl methacrylates. Based on these data methacrylate esters are readily absorbed by all routes and rapidly hydrolyzed by carboxylesterases to methacrylic acid (MAA) and the respective alcohol. Clearance of the parent ester from the body is in the order of minutes.
Also OECD QSAR toolbox v.3.3 suggest as metabolites of 6-chlorohexyl methacrylate (6-CHMA) the hydrolysis compounds (Methacrylic acid CAS 79-41-4 and 6-Chloro-1-hexanol CAS 2009-83-8) and their oxidation products.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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