Registration Dossier
Registration Dossier
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EC number: 943-224-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
A negative study of skin sensitisation is available for the read-across substance aluminium magnesium titanium oxide. |
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A negative study is available for the read-across substance aluminium magnesium titanium oxide. The read-across substance and the registered substance are comparable insoluble ceramic substances. The read-across substance additionally contains magnesium which is not associated with skin sensitising properties. The induction of skin sensitisation is dependent on the binding of chemical components to skin proteins. Given the fact that the registered substance is an insoluble ceramic, the induction of skin sensitisation is not biologically plausible. Additionally the component ions of the substance (i.e. Al, Ti) are not associated with skin sensitisation.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
No data are available for respiratory sensitisation, but this would appear not to be biologically plausible based on the physicochemical properties (i.e. insolubility) of the substance.
Justification for classification or non-classification
Classification for skin sensitisation is not proposed in the absence of any data indicating that the substance is a skin sensitiser. No data are available for respiratory sensitisation, but this would appear not to be biologically plausible based on the physicochemical properties of the substance. |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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