sodium (1R,2R)-2-(2-bromo-5-methoxyphenyl)-1-({3-cyclohexyl-6-[(dimethylsulfamoyl)carbamoyl]-1H-indol-1-yl}methyl)cyclopropanecarboxylate

Guidance on Safe Use

First-aid measures

EYE Contact

IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if

present and easy to do. Continue rinsing.  Immediately call a POISON CENTER or

doctor/physician.  

Skin Contact

Take off contaminated clothing and shoes immediately.  Wash off immediately with plenty

of water for at least 15 minutes.  Discard contaminated clothing or wash before re-use.  Get

medical attention/advice if you feel unwell.

Inhalation:

Move to fresh air.  Oxygen or artificial respiration if needed.  Get medical attention/advice

if you feel unwell.  

Ingestion:

IF SWALLOWED: Immediately call a POISON CENTRE or doctor/physician.  Rinse

mouth.  Do NOT induce vomiting.  Never give anything by mouth to an unconscious

person.  

Medical Surveillance

The need for a pre-placement physical examination and history for employees with

potential exposure to this compound is to be evaluated by a physician that is thoroughly

knowledgeable about both the toxicity of this compound and the extent of work place

exposure.  Baseline testing would include: a blood test for liver function.  Based on

opportunity for exposure and duration of exposure a periodic follow-up examination may

be considered.  It is recommended that the content be similar to the pre-placement exam.  

Employees who are pregnant, are breast-feeding, or who are concerned with other

reproductive issues should be encouraged to consult with the occupational health physician

monitoring worker's health.  

Fire-fighting measures

Flammable Properties   Not readily combustible  

Extinguishing Media  Suitable extinguishing media:  Dry chemical, Water spray, Foam Unsuitable extinguishing media:  Do NOT use water jet.

Protection of  FirefightersSpecific hazards:  Not available

Protective equipment:  Use personal protective equipment.  In the event of fire, wear self-

contained breathing apparatus.  

Hazardous Combustion Products:  carbon oxides (COx), nitrogen oxides (NOx), hydrogen

bromide, sulphur compounds

Further Information:  Hydrogen halide gases can react with metals to form potentially

explosive hydrogen/air mixtures.  In the event of fire and/or explosion do not breathefumes.  

Other information Decontaminate protective clothing and equipment before reuse.  

Accidental release measures

Personal precautions

Refer to protective measures listed in sections 7 and 8.  Use personal protective equipment.

Examples include tightly fitting safety goggles, lab coat and impervious gloves.  Wear

respiratory protection.  Depending on the nature of the spill (quantity and extent of spill)

additional protective clothing and equipment such as a self-contained breathing apparatus

may be needed.  

Environmental precautions

Prevent release to drains and waterways.  Prevent release to the environment.  

Containment Methods  Wet down any dust to prevent generation of aerosols, if appropriate.  Cover with suitable

material.  

Cleanup Methods  Contain and collect spillage and place in container for disposal according to local regulations.  Use a HEPA vacuum or moisten materials to minimize dust generation during pick-up.  Clean area with detergent and water after spill pick-up, if appropriate.  Handle waste materials, including gloves, protective clothing, contaminated spill cleanup material, etc., as appropriate for chemically and pharmacologically similar

materials.  

Handling and storage

Handling Precautions  Avoid exposure - obtain special instructions before use.  Avoid formation of dust and  aerosols.  Keep away from heat and sources of ignition.  Prevent release to drains and waterways.  

Container Requirements  

Store in sturdy containers appropriate to maintain the integrity of this material for its intended use.  

Storage Conditions  Store at room temperature.  Protect against light.  Keep away from heat, sparks and flames.

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

Engineering Controls and Ventilation

Use process enclosures, containment technology, or other engineering controls to keep

airborne levels below recommended exposure limit.  When handling quantities up to 15

milligrams, a standard laboratory with general laboratory dilution ventilation (e.g. 6-12 air

changes per hour) is appropriate.  When handling quantities from 15 milligrams to 1 kilogramwork in a standard laboratory using a fume hood, biological safety cabinet(Class II, all types),

or approved vented enclosure.  Quantities exceeding 1 kilogram should be handled in a

designated laboratory.  A  laminar flow/powder containment booth is recommended for

handling >1 kilograms of active substance.  For manufacturing and pilot plant operations, use

direct coupling and closed transfer systems for all bulk transfers. Use dust tight valves as

appropriate.  HEPA filtration of local exhaust ventilation (LEV) is required.  

Respiratory Protection

Use and selection of respiratory protection is based upon engineering controls in use and

potential for aerosol generation.  When engineering controls are not sufficient control

exposure, wear an approved respirator with NIOSH Class 100 or high efficiency particulate

(HEPA) filters or cartridges (EN 140/EN 136) when exposures are up to 10 times the exposure

control guideline.   Wear a loose-fitting (Tyvek or helmet type) HEPA powered-air purifying

respirator (PAPR) (EN 12941) when exposures are 10-25 times the exposure control

guideline.   Wear a full facepiece negative pressure respirator with Class 100 or HEPA filters

(EN 136) when exposures are 25-50 times the exposure control guideline.   Wear a tightfitting,

itting, full facepiece HEPA PAPR (EN 12942) when exposures are 50-100 times the exposure

control guideline.   Wear a hood-shroud HEPA PAPR (EN 12941) or full facepiece supplied

air respirator (EN 139) operated in a pressure demand or other positive pressure mode when

exposures are 100-1000 times the exposure control guideline.  

Eye Protection

Safety glasses with side-shields are recommended (EN 166).    Face shields or chemical safety

goggles (EN 166) may be required if splash potential exists or if corrosive materials are

present.   Note: Choice of eye protection may be influenced by the type of respirator which is

selected.  

Hand Protection

Impervious nitrile, rubber and latex gloves are recommended (EN 420, EN 374).   If material

is handled in solution, the solvent should also be considered when selecting protective clothing

material.  Please note that employees who are allergic to natural rubber latex should use nitrile

gloves.  

Skin and Body Protection

Wear a laboratory coat (EN 340) when handling quantities up to 1 kilogram.  For quantities

over 1 kilogram, wear laboratory coat(EN 340)or coverall of low permeability (EN 1149-1).

For manufacturing operations, wear coverall of low permeability (EN 465/1149-1).  For

manufacturing operations, wear coverall of low permeability (EN 1149-1).  

Hygiene Wash hands and face before breaks and immediately after handling the product.  

Environmental

exposure controls

Prevent release to drains and waterways

Stability and reactivity

Chemical Stability :  Stable under recommended storage conditions.  

Hazardous Decomposition Products: Hazardous decomposition products formed under fire conditions.: carbon oxides (COx), nitrogen oxides (NOx) hydrogen bromide, sulphur compounds

Disposal considerations

Disposal should be in accordance with applicable regional, national and local

laws and regulations.   Local regulations may be more stringent than regional

or national requirements.  This information presented only applies to the

material as supplied.