Registration Dossier
Registration Dossier
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EC number: 807-448-3 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014-02-13 to 2014-03-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature, in the dark - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 10
- Temp.:
- 40 °C
- pH:
- ca. 3
- Details on results:
- As the test item was a complex mixture and the result was expected to be high, the HPLC method was chosen to be the most suitable method for determination of partition coefficient. The test was modified from that stated in the guideline to allow assessment of the partition coefficient up to a value of log10Pow 10.0 by the use of additional reference standards.
- Conclusions:
- The partition coefficient of the test item was assessed in accordance with OECD Guideline 117 and determined to be >1.00E10 (LogPow >10.0).
- Executive summary:
Test Guidance
The determination was carried out using the HPLC Method, using a procedure designed to be compatible with Method A8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
The test system consisted of a high performance liquid chromatograph with appropriate detectors. A reverse phase HPLC column with a very low percentage of polar groups was used.
Result
The partition coefficient of the test item has been determined to be >1.00E10 (LogPow >10.0)
Reference
Description of key information
The partition coefficient of the test item was assessed in accordance with OECD Guideline 117 and determined to be >1.00E10 (LogPow >10.0).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 10
- at the temperature of:
- 40 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
