(2-ethyl-2-methyl-1,3-dioxolan-4-yl)methyl prop-2-enoate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

12 Dec 2006 - 22 Jan 2007

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

GLP compliance:

yes

Type of method:

flask method

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 09898602
- Expiration date of the lot/batch: > 6 months from receipt date at 25°C
- Physical appearance: yellow liquid
- Date received: 6 Nov 2001
- Purity: 99.8%
- Storage: refrigerated, 1-10°C

Key result

Water solubility:

12.92 g/L

Conc. based on:

test mat. (dissolved fraction)

Incubation duration:

120 h

Temp.:

20 °C

pH:

6.6

Details on results:

Calibration and quality control data are presented in Table 1(Please refer to attached document). The calibration line was established linearly with 1/x weighting.

Analytical and pH data for samples are presented in Table 2 (Please refer to attached document).

The results are illustrated graphically in Figure 3 (Please refer to attached document). It is considered that a plateau was achieved after 48 hours. The reported water solubility value is quoted as the maximum result that was achieved after a plateau had been obtained.

Typical chromatograms for a calibration sample and for a solubility sample are shown in Figure 1 and Figure 2, respectively (Please refer to attached document).

The incubation bath was constant at a temperature of 20.1 °C over the test period.

Conclusions:

The solubility of the test item at nominally 20°C in double distilled water was determined to be 12.92g/L, with a resultant pH of 6.60.

Executive summary:

Introduction-

The solubility of the Subject Chemical at
nominally 20°C in double distilled water was determined by a shake flask method to be
12.92 g/L, with a mean resultant pH of 6.60. 

Results

Please refer to attached document.

Conclusion

The solubility of the Subject Chemical at nominally 20°C in double distilled water was determined by a shake flask method to be 12.92 g/L, with a resultant pH of 6.60.

Description of key information

The water solubility of the test item has been determined to be 12.92 g/L at 20.0 °C and pH of 6.60.

Key value for chemical safety assessment

Water solubility:

12.92 mg/L

at the temperature of:

20 °C

Additional information

The determination of water solubility of MEDOL-10 was carried out by the flask method (Covance Laboratories Limited, 20007, Study 2777/001-D2149). The procedure was designed to be compatible with the EC Method A.6, the OECD test guideline 105 and the EPA test guideline OPPS 830.7840, and was conducted in compliance with GLP.

 

The water solubility of the test item has been determined to be 12.92 g/L at 20.0 °C and pH of 6.60.