Registration Dossier
Registration Dossier
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EC number: 940-543-9 | CAS number: 354-15-4
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- The data source is considered reliable, altough no details on the measurement method are given.
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- not reported
- GLP compliance:
- not specified
- Type of method:
- other: not reported
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 2.47
- Conclusions:
- According to the data source, the log Kow of HCFC 122a is 2.47.
- Executive summary:
The objective of the reported reference was to study the toxicity of refrigerants HFCF 122a and HCFC 132 and to characterize their biological action in order to validate the approximate safe level of these compounds in the air of working area, ambient air, and water. In this study both a review of the available toxicological data on similar chemical compounds and acute and subacute toxicological tests on HFCF 122a and HCFC 132 were made.
A summary of the chemical and physical properties of the two substances was also included in the report, indicating a log Kow of 2.47 for HFCF 122a. Under the study the value was used for the calculation of the estimated median lethal dose in case of oral administration and the estimatedmedian lethal concentration in air.
The partition coefficients Oil/Air (log K) and water/air (log D) were also reported:
log K = 2.58
log D = -0.39
Reference
The partition coefficients Oil/Air (log K) and water/air (log D) were also reported:
log K = 2.58
log D = -0.39
Description of key information
The Log Kow of HCFC 122a is 2.47.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.47
Additional information
A reliable reference is reported, indicating a log Kow = 2.47 for HCFC 122a.
The same data source also reports the partition coefficients Oil/Air (log K) and water/air (log D):
log K = 2.58
log D = -0.39
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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