Registration Dossier
Registration Dossier
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EC number: 939-702-5 | CAS number: -
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
A key study was conducted in accordance with the OECD 301 F testing guideline as well as GLP requirements. As the substance has low water solubility and is an UVCB, it is considered "difficult to test". Consequently, both "direct addition" (40 mg test substance/L) and "improved dispersibility" (40 and 100 mg test substance/L, plus emulsifying agent "Synperonic P103") methods were included in the test design. An extended testing period of 60 days was considered justifiable, as the substance is poorly soluble and did not reach a plateau within 28 days.
The substance reached an average of 19.9% biodegradation at day 28 when added directly to the test medium, and 36.2 - 41.3% biodegradation when added along with the emulsifying agent. By day 60, the substance had reached 52.2% (40 mg test item/L + emulsifying agent), 56.2% (100 mg test item/L + emulsifying agent) and 65.5% (40 mg test item/L, direct addition) biodegradation levels, which indicates significant potential for ultimate biodegradation.
In addition, the biodegradation potential of all relevant main constituents of the test substance was assessed using an in-silico approach (supporting study; Klimisch reliability score of 2), the BOD QSAR Model “LMC OASIS CATALOGIC 301C”. This model also identifies the biotic degradation products of the test substance. The in silico approach was chosen as the most appropriate method to assess the degradation products considering that the parent substance is a complex UVCB consisting of several major constituents. For all assessed constituents, primary half-life values ranged from 3.60 to 6.27 days and ultimate half-life values ranged from 29.59 to 30.71 days, indicating that none of those constituents nor their degradation products are likely to fulfill the P criterion.
Two additional experimental supporting studies are available, although both are considered unreliable (Klimisch 3) due to significant methodological deficiencies.
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable
- Type of water:
- freshwater
Additional information
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