Registration Dossier
Registration Dossier
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EC number: 939-579-8 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
OECD Guideline 203, EU Method C.1, GLP, key study, validity 2:
96h-LC50 = 1.61 mg dry extract/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.61 mg/L
Additional information
One key study is available to assess the 96h-acute toxicity of Chimexane HB to fish (Rainbow trout). This study was performed according to the principles of OECD 203 and Commission EC Regulation 440/2008 Method C.1 with GLP statement.
The test was conducted under static condition, using five concentrations (0.21, 0.47, 1.03, 2.27 and 5.00 mg test item/L, corresponding to nominal dry extract concentrations of 0.114, 0.256, 0.560, 1.23 and 2.72 mg/L) plus control, one replicate per test concentration and the control. Seven test organisms were exposed to each test concentration and control. Concentrations were analytically verified for the active ingredient C12 via LC-MS/MS at the beginning and end of test or whenever mortality occurred. The recovery rates of the test item were for the active ingredient C12 82 -93% at test start and 32 -98% at test end. All effect levels are given based on geometric mean measured concentrations of the test item and expressed as dry extract concentrations of the test item.
Since after 24 -96h only 0 and 100% mortality was found, no regression analysis was carried out. Hence the LC50 is the geometric mean value of the concentration with 0% mortality (LC0 = 2.16 mg test item/L, corresponding to 1.18 mg dry extract/L) and 100% mortality (LC100 = 4.06 mg test item/L, corresponding to 2.21 mg dry extract/L). The LC50 after 96 hours is 2.96 ( 2.16- 4.06) mg/ test item/L, corresponding to 1.61 (1.18 - 2.21) mg dry extract/L.
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