Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-579-8 | CAS number: -
Melting point / freezing point
Administrative data
Link to relevant study record(s)
Description of key information
A study on the CHIMEXANE HB lyophilised was conducted and led to a Melting range from 163 to 166°C at atmospheric pressure.
Another study on the product as marketed was conducted : The melting of the CHIMEXANE HB as marketed, i.e. containing 45% of water, occurred progressively between -50°C and 7.5°C.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- -50 °C
Additional information
A GLP study was performed in order to determine the melting point of the CHIMEXANE HB lyophilised according to OECD 102 and EU method A.1.
In this study, the differential scanning calorimetry (DSC) method and the capillary method were used. The CHIMEXANE HB lyophilised has a melting range from 163 °C to 166 °C at atmospheric pressure (1013.25 hPa). The result has been considered as reliable without restriction because the test was performed in compliance with edicted guidelines giving scientifically valid results.
Considering that the substance is always placed on the market in aqueous solution, the measurement of the melting point has also been performed on the substance as marketed, containing 45% of water.
The test to determine melting temperature of CHIMEXANE HB was conducted in compliance with the OECD guideline 102 and the EU method A.1. using the Differential Scanning Calorimetry method (DSC).
For that, the test item was heated up from -100°C to the final temperature of 50°C at a constant heating rate (10K/min ± 0.1K) in a defined atmosphere (nitrogen).
Because the difference between the temperature at the beginning and the final stage of melting was not situated within the range of the estimated accuracy of the method, two temperatures were presented. Melting of the test item occurred progressively in a range of temperature :
- The mean temperature value of the beginning of melting (on 2 assays) was : -50°C
- The mean temperature value of the final stage of melting (on 2 assays) was : 7.5°C
The melting range was retained as key data for purpose of CSA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
