Reaction mass of [(2-substituted-4-nitroaryl)diazenyl]methyl(arylamino)-[(2-arylethyl)amino]pyridinecarbonitrile and [(2-substituted-4-nitroaryl)diazenyl]methyl(arylamino)-[(2-arylethyl)amino]pyridine-3-carbonitrile

Toxicity to microorganisms

Description of key information

There was no evidence of bacterial toxicity of FAT 41030/A in an Activated Sludge Respiration  Inhibition Test (OECD 209). The IC50 and IC20 values were greater than 1000 mg/L. It is concluded that its structural analogue FAT 41045 also is not toxic to bacteria.

Key value for chemical safety assessment

EC50 for microorganisms:

1 000 mg/L

EC10 or NOEC for microorganisms:

1 000 mg/L

Additional information

Bacteria toxicity of FAT 41030/A, a structural analogue of FAT 41045, was determined according to OECD 209 and 67/548/EEC, Part C in compliance with GLP. Both substances are very similar in their chemical structure and, as demonstrated, in a number of physicochemical properties. Therefore, the use of this study for read-across is considered to be appropriate.

 

At all applied test concentrations, FAT 41030/A showed no significant toxic effects (% inhibition of the respiration rate <15 %) to the activated sludge. The respiration rates were in the same range as determined in the controls. Hence, the IC₅₀ and the IC₂₀values for the test item were greater than 1000 mg/L. The same is concluded for FAT 41045.