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Diss Factsheets
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EC number: 939-460-0 | CAS number: 1471311-26-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In a key study performed to OECD Guideline 406, a test group of 6 male and 6 female Hartley albino guinea pigs was dosed topically with the test material (100%) one time per week for three weeks for a total of three induction exposures. The duration of the exposures was 6 hours. Two weeks after the last induction exposure Test group animals were challenge dosed for detection of sensitisation by topical application of a known non-irritating concentration of the test material (50% in acetone) to previously unexposed areas of the skin. One week after challenge dosing, the Test Group animals were rechallenged to confirm the initial challenge results.
There were no deaths, clinical findings or remarkable body weight changes.
The positive control material, dinitrochlorobenzene, was demonstrated to be an extreme sensitizing agent in albino guinea pigs under the conditions of this study based on the Sensitization Incidence Index of 83%, thereby demonstrating the reliability of the test system.
There was one reaction in the Test Group that exceeded the highest reaction in the Naive Control Group I, following dosing with 50% w/v concentration of the test material in acetone. The Sensitization Incidence Index was calculated to be 8% for the Test Group following challenge dosing. There were two sensitization reactions (2/12) in the Test Group following rechallenge dosing with a 50% w/v concentration of the test material in acetone.
The Sensitization Incidence Index was calculated to be 17% for the Test Group following rechallenge dosing.
In accordance with CLP Regulation (EC) No 1272/2008 the test material is classified for skin sensitisation
Migrated from Short description of key information:
After rechallenge with 50% test material in acetone 2/12 animals showed a sensitisation reaction (17% sensisation). The substance is a skin sensitiser.
Justification for classification or non-classification
The skin Sensitization Incidence Index was calculated to be 17% for the Test Group following rechallenge dosing.
In accordance with CLP Regulation (EC) No 1272/2008 the test material is classified for skin sensitisation
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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