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Diss Factsheets
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EC number: 695-101-5 | CAS number: 1275611-65-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.264 µg/L
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.16 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.026 µg/L
- Assessment factor:
- 500
- Extrapolation method:
- assessment factor
- PNEC marine water (intermittent releases):
- 0.016 µg/L
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 0.2 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 1.07 mg/kg sediment dw
- Assessment factor:
- 1
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.107 mg/kg sediment dw
- Assessment factor:
- 1
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 2.5 mg/kg soil dw
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 0.22 mg/kg food
- Assessment factor:
- 90
Additional information
Conclusion on classification
For classification and labeling (PBT and CLP) the available (bulk) effect data are as a worst-case divided by a factor of 10, thus in fact it is assumed that 90% was sorbed where EUSES calculates that only 5% is sorbed using the Kd of 1763 L/kg.
The short term fish test (Akzo Nobel, 2017) with N-C16 -18 -alkyl-(even numbered, C18 unsaturated) trimethylpropane-1,3 -diamine (Methylated diamine) gave a LC50 of >0.016 mg a.i./L (Threshold test).
No acute short term daphnia test has been performed for this substance. As a realistic worst-case the long term parental EC50 for mortality (Scheerbaum, 2017) of >0.1 mg a.i./L is used for this endpoint.
The algae test (Scheerbaum, 2017) with Methylated diamine gave an ErC50 of 0.016 mg a.i./L.
The lowest short term toxicity observed is within the range: 0.001 < L(E)C50≤0.01 including the correction for mitigation for using the bulk approach.
This leads to an acute 1 classification and an M-factor of 100
For the long term environmental classification of Methylated diamine no read across from other substances is considered necessary as there are two long term study endpoints for Methylated diamine available and fish are based on the acute data and similar to primary alkyl amines, diamines, quaternary ammonium compound etc. expected to be less sensitive to Methylated diamine when compared to daphnia and algae.
There are two long term studies available with Methylated diamine.
The algae test (Scheerbaum, 2017) with Methylated diamine gave an ErC10 of 0.0132 mg a.i./L.
The long term daphnia test (scheerbaum, 2017) with Methylated diamine gave an EC10 (reproduction) of >0.1 mg a.i./L. The 21d NOEC for adult mortality is >0.1 mg a.i./L.
The lowest long term toxicity value is within the range: 0.001 < EC10≤0.01 including the correction for mitigation for using the bulk approach.
This leads to a chronic 1 classification and an M-factor of 10 because the substance is rapidly biodegradable (RD)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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