1,4-Diazabicyclo[2.2.2]octane-2-methanol

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

substances / mixtures which in contact with water emit flammable gases

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the experience in production or handling shows that the substance does not react with water, e.g. the substance is manufactured with water or washed with water

Reference 2

Endpoint:

pyrophoric solids

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is known to be stable in contact with air at room temperature for prolonged periods of time (days) and hence, the classification procedure does not need to be applied

Reference 3

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

18 Feb-15 Apr 2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

Qualifier:

according to guideline

Guideline:

other: United Nations (UN) Test N.1: “Test Method for Readily Combustible Solids”, 2009.

Deviations:

yes

Remarks:

No wetting zone was applied beyond the 100 mm timing zone during the burning rate test. It was technical not possible to prepare a wetting zone due to the high solubility of the compound.

GLP compliance:

yes (incl. QA statement)

Remarks:

GLP Compliance Monitoring Program, Health Care Inspectorate, Ministry of Health, Welfare and Sport, Den Haag, The Netherlands

Test procedure:

burning time (test type not further specified)

Remarks:

or specified in description of method

Burning time:

38 s

Remarks on result:

other: burning rate 2.63 mm/s

Preliminary test

The flame of the gas burner did ignite the test substance pile. The test substance melted, burned with a blue yellow flame and turned into a brown residue. After the pile had burned a distance of 50 mm, the time of burning over a distance of 200 mm was measured to be 71 seconds (i.e. 2.8 mm/s).

Burning rate test

After the pile had burned a distance of 80 mm, the burning time over 100 mm was measured to be 38 seconds. The test was performed once, since it confirmed the preliminary screening test in which two positive results were observed.

Interpretation of results:

Category 1 (flammable solids) based on GHS criteria

Description of key information

flammable on ignition (EU A.10, UN N.1 without wetting zone application)
non-flammable on contact with water (based on structure and experience in handling and use, in accordance with guidelines EU A.12 and UN N.5)
non-pyrophoric (based on structure and experience in handling and use, in accordance with guidelines EU A.13 and UN N.2)

Key value for chemical safety assessment

Flammability:

flammable

Additional information

The influence of a wetted zone, as required according to the guideline UN.1, could not be investigated because of a high solubility of the test substance in water.

Justification for classification or non-classification

According to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures, the substance is considered to be a flammable solid, Category 1, and as R11 according to Directive 67/548/EEC. The Category 1 is assumed as the worst-case scenario, because the influence of the wetted zone cannot be investigated for technical reasons. Based on the chemical structure and experience in handling and use, pyrophoricity and flammability on contact with water are not expected.