Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2020-12-08 to 2020-12-09
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
1.76
Temp.:
22.32 °C
pH:
7.425
Remarks on result:
other: SD +/- 0,02

Mass Balance for the Test Item in n-Octanol- and Aqueous Phase

 n-octanol / water ratio Nominal mass1)[mg]   Repl.  Meas. conc. in n-octanol [mg/L] Mass in n-octanol [mg]   Meas. conc. in aq. phase [mg/L]  Mass in aq. phase [mg] Sum mass [mg]   RR [%]
2:1     34.9     1  937 30.9 17.6   0.3 31.2   89
 2  939  31 16.3  0.277 31.3   89
1:1     26.5      1  971  24.3  16.9  0.423 24.7   93
 2  970  24.2  17.2  0.43  24.7  93
1:2 18.0  1  963  16.4  15.6  0.516  16.9  94
 2  946  16.1  15.8  0.521  16.6  92

1) = Based on the measured concentration of the stock solution at test start

Repl. = Replicate

Meas. conc. = Measured concentration, mean value of two injections, dilution factors taken into account

aq. phase = Aqueous phase

RR = Recovery rate, related to the nominal

Concentrations in n-Octanol- and Aqueous Phase, log POW

n-octanol / water ratio

 Repl.

 Meas. conc. in n-octanol [mg/L]

 Meas. conc. in aq. phase [mg/L]

POW

log POW    

Diff

mean +/- SD (max-min)

2:1    

 1

 937

17.6 

 53.14

1.73 

1.76

0.02

0.06

 

 2

 939

16.3

 57.67

1.76 

1:1    

 1

 971

 16.9

 57.31

1.76 

 2

 970

 17.2

 56.37

 1.75

1:2

 1

 963

 15.6

 61.56

 1.79

 2

 946

 15.8

 59.96

 1.78

SD = Standard deviation

Conclusions:
The partition coefficient (n-octanol / water) of the test item was determined at 22.32 °C to be 1.76 ± 0.02.

Description of key information

Based on experimental data the partition coefficient (n-octanol / water) of the test item was determined at 22.32 °C to be 1.76 ± 0.02.

Key value for chemical safety assessment

Log Kow (Log Pow):
1.76
at the temperature of:
22.32 °C

Additional information