2-Methoxy-4-methylphenyl methyl carbonate

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

10-01-2012 to 19-01-2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study performed under GLP. All relevant validity criteria were met.

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

inspected: July 2012; signature: November 2012

Type of method:

gas saturation method

Temp.:

25 °C

Vapour pressure:

0.1 Pa

Table 2: Results of the vapour pressure determinations

Saturator Column.	Temp. [°C]	Volume, V* [mL]	Mass of Test Item in Trap 1 [μg]	Mass of Test Item in Trap 2 [μg]	Total Mass of Test Item [μg]	Vapour Pressure [Pa]	Average Vapour Pressure [Pa]
A B C	30	39654 52872 66096	665.080 932.880 1194.880	none detected	665.080 932.880 1194.880	0.215 0.227 0.232	0.225
A B C	40	14789 19719 24648	879.480 1185.160 1554.560	none detected	879.480 1185.160 1554.560	0.789 0.797 0.837	0.808
A B C	50	6388 8518 10647	1198.920 1629.320 2116.200	none detected	1198.920 1629.320 2116.200	2.57 2.62 2.72	2.64

*Corrected volume at test temperature as calculated under “Volume correction”

Table 3: Data of the vapour pressure curve

T [°C]	1/T [K]	ln Pvp
30	3.3E-03 3.3E-03 3.3E-03	-1.54 -1.48 -1.46
40	3.19E-03 3.19E-03 3.19E-03	-0.24 -0.23 -0.18
50	3.09E-03 3.09E-03 3.09E-03	0.94 0.96 1.00

The tabulated results represent rounded-off values obtained by calculations based on the exact raw data.

Y = b x + a

where:

Y = ln (P_vp mean in Pa)

x = 1/T (K)

b = - 12062.22 (slope)

a = 38.30 (y-axis intercept)

r²= 0.9993

Validation:

The linearity of the detector response with respect to concentration was assessed over the concentration range of 20.5 to 205 mg/L. This was satisfactory with a correlation coefficient of 1.000 being obtained.

Discussion:

To ensure saturation control, three different flow rates were used at each temperature. From the data in Table 2 it can be clearly seen that higher flow rates did not lead to lower vapour pressures, which means that the nitrogen was saturated with test item under the conditions of the test.

Conclusions:

The vapour pressure of the test item has been determined to be 0.1 Pa at 25 °C.

Executive summary:

The vapour pressure was determined using EU Method A.4 and OECD TG 104 using the gas saturation method under GLP. The test item vapour pressure was calculated by extrapolation of the measured vapour pressure curve encompassing three temperatures under the conditions of the method. The calculated vapour pressure was 0.1 Pa at 25 °C.

Description of key information

Vapour Pressure: 0.1 at 25 °C, EU Method A.1 – Gas Saturation Method, 2012

Key value for chemical safety assessment

Vapour pressure:

0.1 Pa

at the temperature of:

25 °C

Additional information

The vapour pressure was determined using EU Method A.4 and OECD TG 104 using the gas saturation method under GLP. The test item vapour pressure was calculated by extrapolation of the measured vapour pressure curve encompassing three temperatures under the conditions of the method. The calculated vapour pressure was 0.1 Pa at 25 °C.