Registration Dossier
Registration Dossier
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EC number: 700-604-0 | CAS number: 947701-81-7
Endpoint summary
Administrative data
Description of key information
The acute oral median lethal dose (LD50) of the test material UMC in the female Wistar strain rat was estimated to be greater than 2000mg/kg bodyweight (Globally Harmonised Classification System-Unclassified).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Due to the nature of the end use of the substance (cosmetic ingredient) the registered substance UC was not used for animal testing. A surrogate substance Undecenyl methoxycrylene has been identified as the most suitable substance to conduct the animal studies on, therefore the classification for UC has been based on the results from Undecenyl methoxycrylene. Please see section 13 for our justifications as to why UMC should be a sufficient surrogate material.
The study was performed to assess the acute oral toxicity of the test material UMC in the Wistar strain rat. The method was designed to meet the requirements of the following:
§ OECD Guidelines for Testing of Chemicals No 420 “Acute Oral Toxicity - Fixed Dose Method” (2001)
§ Method B1 bis Acute Toxicity (Oral) of Commission Regulation (EC) No. 440/2008
Justification for classification or non-classification
The acute oral median lethal dose (LD50) of the test material UMC in the female Wistar strain rat was estimated to be greater than 2000mg/kg bodyweight (Globally Harmonised Classification System-Unclassified).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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