Registration Dossier
Registration Dossier
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EC number: - | CAS number: 37486-69-4
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 Sept - 29 Oct 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, non-GLP
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
- Reference Type:
- other: reanalysis of data
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- flask method
Test material
- Details on test material:
- Name of test material (as cited in study report): TFEE-5
- Physical state: Colorless liquid
- Analytical purity: 97.21%
- Stability under test conditions: Test item stable
- Storage condition of test material: Ambient temperature, 10-30 °C
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- >= 0.26 - <= 0.29 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 10 g/L
- Incubation duration:
- >= 4 - <= 11 d
- Temp.:
- 25 °C
- pH:
- >= 6.9 - <= 7.1
- Details on results:
- Solubility reported as 0.3 mg/L
Any other information on results incl. tables
Concentrations were measured in duplicate at three time points. Results are indicated below:
22 hrs 0.16 ± 0.014 mg/L, pH 6.9
4 days 0.26 ± 0 mg/L, pH 7.1
11 days 0.29 ± 0.057 mg/L, pH 6.9
The concentrations on days 4 and 11 were not significantly different (< 15%), establishing that the samples had come to equilibrium.
Applicant's summary and conclusion
- Conclusions:
- The water solubility of TFEE-5 at 25 °C, pH 7 is 0.3 mg/L (OECD 105)
- Executive summary:
The water solubility of TFEE was determined according to EC No. 440/2008, A.6 and OECD TG105. Two grams of TFEE-5 were stirred at 30 °C for 24 hours followed by equilibration at 25 °C for up to 11 days. Concentration in the water phase was not significantly different between days 4 and 11. The water solubility of TFEE-5 at 25 °C, pH 7 is 0.3 mg/L.
The test followed internationally accepted guidelines but was not conducted under GLP or equivalent criteria. Therefore, this study is classified as reliable with restrictions.
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