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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May 2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Justification for type of information:
The test was considered as reliable with restriction as it was not performed under GLP and that because of the very high solubility of the test item (> 100 g/L), only an upper value could be determined due to HPLC analytical limitations.
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
no
Type of method:
flask method
Specific details on test material used for the study:
Identification: Short-chain fructo-oligosaccharides
EC No. :908-300-1
Appearance: Slightly yellow powder

COMPOSITION:
Total FOS:96% expressed as dry matter
1-Kestose (GF2): 37.1% expressed as dry matter
Nystose (GF3): 50.5% expressed as dry matter
1F-Fructofuranosylnystose (GF4): 12.4% expressed as dry matter
Other components:Glucose +Fructose + Saccharose : 4% expressed as dry matter
Key result
Water solubility:
>= 144 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
144 g/L
Incubation duration:
ca. 24 h
Temp.:
25 °C
pH:
ca. 6.7
Remarks on result:
completely miscible

Measuring very high solubilities is challenging from a materials-handling perspective as such concentrated samples often form gels and are too viscous to filter, making it difficult to determine what is actually dissolved. The response of the HPLC instrument is also generally no longer linear, making calibration challenging. That is why only an upper value could be determined during this test.

Conclusions:
The solubility of the test item in water was ≥ 144 g/L at 25°C and pH 6.7.
Executive summary:

The water solubility of the test item was investigated in a study performed in accordance with EC A.6 method and OECD Guideline No. 105, using the Flask method with HPLC analysis. The solubility of the test item in water was ≥ 144 g/L at 25°C and pH 6.7.

Description of key information

The water solubility of the test item was investigated in a study performed in accordance with EC A.6 method and OECD Guideline No. 105, using the Flask method with HPLC analysis. The solubility of the test item in water was ≥ 144 g/L at 25°C and pH 6.7.

Key value for chemical safety assessment

Water solubility:
144 g/L
at the temperature of:
25 °C

Additional information

The water solubility of the test item was investigated in a study performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and is selected as a key study for the endpoint.