Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 908-343-6 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
The DNELs for local inhalation effects are based on the corresponding DNELs that are available for hydrogen peroxide, taking into account that:
a) according to the stoichiometry of the hydrolysis reaction of calcium peroxide, an equimolar amount of hydrogen peroxide is formed; and that
b) the reaction mass of calcium carbonate and calcium dihydroxide and calcium peroxide typically contains 75% of calcium peroxide.
Worker – inhalation – local effects – long term
DNEL (hydrogen peroxide): 1.4 mg/m3
a) stoichiometrie
1.4 mg hydrogen peroxide = 4.116E-05 mol hydrogen peroxide
= 4.116E-05 mol calcium peroxide
4.116E-05 mol calcium peroxide = 3.0 mg calcium peroxide
DNEL (calcium peroxide) = 3.0 mg/m3
b) composition of reaction mass
DNEL (calcium peroxide) = 3.0 mg/m3
DNEL (reaction mass) = 4.0 mg/m3
As synergistic effects between hydrogen peroxide and calcium dihydroxide cannot be excluded (both have local effects), an extra assessment factor of 2 is taken into account.
The final DNEL for the reaction mass of calcium carbonate and calcium dihydroxide and calcium peroxide therefore is:
DNEL (reaction mass) = 2.0 mg/m3
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.3 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - General Population
The DNELs for local inhalation effects are based on the corresponding DNELs that are available for hydrogen peroxide, taking into account that:
a) according to the stoichiometry of the hydrolysis reaction of calcium peroxide, an equimolar amount of hydrogen peroxide is formed; and that
b) the reaction mass of calcium carbonate and calcium dihydroxide and calcium peroxide typically contains 75% of calcium peroxide.
General population – inhalation – local effects – long term
DNEL (hydrogen peroxide): 0.21 mg/m3
a) stoichiometrie
0.21 mg hydrogen peroxide = 6.174E-06 mol hydrogen peroxide
= 6.174E-06 mol calcium peroxide
6.174E-06 mol calcium peroxide = 0.44 mg calcium peroxide
DNEL (calcium peroxide) = 0.44 mg/m3
b) composition of reaction mass
DNEL (calcium peroxide) = 0.44 mg/m3
DNEL (reaction mass) = 0.59 mg/m3
As synergestic effects between hydrogen peroxide and calcium dihydroxide cannot be excluded, an extra assessment factor of 2 is taken into account.
The final DNEL for the reaction mass of calcium carbonate and calcium dihydroxide and calcium peroxide therefore is:
DNEL (reaction mass) = 0.3 mg/m3
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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