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Diss Factsheets

Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 15 February 2017 to 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose for cross-reference:
reference to other study
Qualifier:
according to guideline
Guideline:
EU Method A.23 Partition Coefficient (1-Octanol/Water): Slow-Stirring Method
Qualifier:
according to guideline
Guideline:
OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
GLP compliance:
yes (incl. QA statement)
Type of method:
slow-stirring method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
3
Temp.:
20 °C
pH:
5
Remarks on result:
other: Dioctyl hydrogen phosphate measured
Remarks:
An accurate log Kow will be indicated when the experimental phase of the study is over.
Type:
log Pow
Partition coefficient:
-0.5
Temp.:
20 °C
pH:
5
Remarks on result:
other: Octyl dihydrogen phosphate measured
Remarks:
An accurate log Kow will be indicated when the experimental phase of the study is over.

The test item partition coefficient was defined (in a worst case approach) as the highest value obtained for one of the two main constituents.

Conclusions:
The partition coefficient of the test item two main constituents was determined.
The test item partition coefficient was defined (in a worst case approach) as the highest value obtained for one of the two main constituents. Therefore at 20°C and pH5, the test item log Kow is 3.
Based on the values obtained from the two main constituents of the test item, it is considered to not possess a potential for bioaccumulation.
Executive summary:

The partition coefficient of the test item was determined with the slow stirring method according to recognised guidelines and under GLP. No deviation from the guideline was observed in the study.

The partition coefficient of the test item two main constituents was determined.

The test item partition coefficient was defined (in a worst case approach) as the highest value obtained for one of the two main constituents.. Therefore at 20°C and pH5, the test item log Kow is 3.

Based on the values obtained from the two main constituents of the test item, it is considered to not possess a potential for bioaccumulation.

The experimental phase of the study is still ongoing. An accurate log Kow will be indicated when the phase is over.

Description of key information

The test item partition coefficient was determined in a key study of Klimisch validity one, performed according to recognised guideline and under GLP.

Key value for chemical safety assessment

Log Kow (Log Pow):
3
at the temperature of:
20 °C

Additional information

The partition coefficient of the test item two main constituents was determined.

The key value used for chemical safety assessment corresponds to the highest value obtained for one of the two main constituents of the test item in a worst case approach.

Based on the values obtained from the two main constituents of the test item, it is considered to not possess a potential for bioaccumulation.

The experimental phase of the study is still ongoing. An accurate log Kow will be indicated when the phase is over.