Registration Dossier
Registration Dossier
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EC number: 619-383-6 | CAS number: 98967-40-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
All four of the studies addressed different aspects of genetic toxicity. All were performed in accordance with recognised EPA guidelines and to GLP standard. All of the studies were considered reliable enough to be key.
No evidence of genetic toxicity was seen in any of the available studies.
Short description of key information:
Three in-vitro genetic toxicity studies are available:
Mendrala AL (1988b): Bacterial reverse mutation assay (AMES): Negative
Linscombe VA & Gollapudi BB (1988): Mammalian cell gene mutation assay: Negative
Mendrala AL (1988a): Unscheduled DNA Synthesis (UDS) assay: Negative
On in-vivo genetic toxicity study is available:
McClintock ML & Gollapudi BB (1988): In-vivo cytogenicity: Negative
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
With reference to the information available on this substance, no classification for genetic toxicity is required in accordance with Directive 67/548/EEC or Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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