Hydrocarbons, C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%)

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

toxicity to microorganisms, other

Remarks:

Growth inhibition

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance

Reason / purpose for cross-reference:

read-across: supporting information

Qualifier:

no guideline followed

Principles of method if other than guideline:

The aquatic toxicity was estimated by a QSAR, the Petrotox computer model (v. 3.04). This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (Kmw) that describe the partitioning of the hydrocarbons between the water and organism

GLP compliance:

no

Remarks:

The data were calculated by a computer model

Analytical monitoring:

not required

Vehicle:

no

Test organisms (species):

Tetrahymena pyriformis

Test type:

other: QSAR modeled data

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Key result

Duration:

48 h

Dose descriptor:

other: EL50

Effect conc.:

43.98 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Key result

Duration:

48 h

Dose descriptor:

other: NOELR

Effect conc.:

1.116 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Validity criteria fulfilled:

yes

Conclusions:

The estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value for this substance is 43.98 mg/L based on growth inhibition

Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (K_MW) that describe the partitioning of the hydrocarbons between the water and organism.

The estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value for this substance is 43.98 mg/L based on growth inhibition.

Reference 2

Endpoint:

toxicity to microorganisms, other

Remarks:

Growth Inhibition

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance

Qualifier:

no guideline followed

Principles of method if other than guideline:

The aquatic toxicity was estimated by a QSAR, the Petrotox computer model (v. 3.04). This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (Kmw) that describe the partitioning of the hydrocarbons between the water and organism

GLP compliance:

no

Remarks:

The data were calculated by a computer model

Analytical monitoring:

not required

Vehicle:

no

Test organisms (species):

Tetrahymena pyriformis

Test type:

other: QSAR modeled data

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Key result

Duration:

48 h

Dose descriptor:

other: EL50

Effect conc.:

185.1 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Key result

Duration:

48 h

Dose descriptor:

other: NOELR

Effect conc.:

1.705 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Validity criteria fulfilled:

yes

Conclusions:

The estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value for this substance is 185.1 mg/L based on growth inhibition

Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (K_MW) that describe the partitioning of the hydrocarbons between the water and organism.

The estimated protozoan,Tetrahymena pyriformis, 48-hr EL50 value for this substance is 185.1 mg/L based on growth inhibition.

Description of key information

There is data available for Hydrocarbons, C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%). Additionally, data is also available for a structural analogue, Hydrocarbons, C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%). This data is read across to based on analogue read across and a discussion and report on the read across strategy is provided as an attachment in IUCLID Section 13.

The estimated protozoan, Tetrahymena pyriformis, 48-hr EL₅₀ value for Hydrocarbons, C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%)is 43.98 mg/L based on growth inhibition.

The estimated protozoan, Tetrahymena pyriformis, 48-hr EL₅₀ value for Hydrocarbons, C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) is 185.1 mg/L based on growth inhibition.