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Diss Factsheets
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EC number: 601-495-1 | CAS number: 117829-74-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1010 (Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids)
- Qualifier:
- according to guideline
- Guideline:
- ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- EEC Directive 92/32/EEC Annex V, part C
- Qualifier:
- according to guideline
- Guideline:
- other: International Standard ISO/DIS 10706 (Water quality - Determination of long term toxicity of substances to Daphnia magna STRAUS)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3-(dimethylamino)propan-1-ol hydrochloride
- EC Number:
- 601-495-1
- Cas Number:
- 117829-74-0
- Molecular formula:
- C5 H13 N O. Cl H
- IUPAC Name:
- 3-(dimethylamino)propan-1-ol hydrochloride
- Details on test material:
- - name of test material (as cited in study report): 3-Dimethylamino-Propanol-Hydrochlorid-1
- batch number: KT 215
- product number : 63181
- aggregate state: liquid
- water-solubility (mg/L): 100
- colour: colourless-clear
- homogeneity: yes
- stability: stability of test substance over test period guaranteed by sponsor
- storage conditions: ambient
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- - test substance stirred in M4 medium for ca. 10 minutes
- nominal concentration of stock solution: 100 mg/L
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Daphnia magna STRAUS 1820 clone was supplied by the Institut National de Recherche Chimique Appliquée, France, in 1978. Since then, clone was
cultured and bred continuously in BASF's Laboratory Experimental Toxicology and Ecology in Ludwigshafen
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 20.4 - 20.6 °C
- pH:
- - pH range at start of test : 7.7 - 8.0
- pH range at end of test: 8 - Dissolved oxygen:
- - oxygen range at start of test (mg/L): 8.6 - 8.9
- oxygen range at end of test (mg/L): 8.4 - 8.6 - Nominal and measured concentrations:
- - concentrations (mg/L): 12.5, 25, 50, 100 (nominal)
- analytical recovery rate of > 80 % - Details on test conditions:
- TEST SYSTEM
- Test vessel: test tubes (glass) with flat bottom (nominal volume 20 ml)
- Test volume: 10
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of animals per concentration: 20
- Loading (animals/ml): 0.5
- No. of replicates for the measurement of pH and O2: 1
- No. of parallels without animals: 1 per test concentration and control for measurement of pH and O2 content at beginning of test. 2 per
concentration and control for concentration control analysis
TEST MEDIUM PARAMETERS
- Alkalinity up to pH 4.3: 0.8 - 1 mmol/L
- Molar ratio Ca/Mg: ca. 4:1
- Conductivity (µS/cm) 550 - 650
- Culture medium different from test medium: no
- Total hardness (mmol/L): 2.20 - 3.20
- after preparation, M4 medium is aerated for ca. 24h until oxygen saturation is reached
OTHER TEST CONDITIONS
- Photoperiod: day:night rhythm = 16:8h
- Light intensity (µE/(m2*s)): ca. 2 - 7 at wave length of 400 - 700 nm
- Illumination: artificial light, type warm white
TEST ORGANISM
- Age of animals at start of test: 2 - 24h (starting with 3rd breed of parent animals)
- Age of stock animals: 2 - 4 weeks
- Feeding: none
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Test parameter: swimming ability of test animals
- check of the study and recording: visually after 0, 24 and 48h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- duration 24h EC0 >=100 nominal test mat. mobility
duration 24h EC50 > 100 nominal test mat. mobility
duration 24h EC100 > 100 nominal test mat. mobility
Any other information on results incl. tables
Analytically determined concentrations of the test substance in the test solutions. Values are given in percent of nominal concentrations:
Time Daphnia Values in % of nominal concentration
[h] Min Max
-----------------------------------------------------------
0 no 100 100
48 no 97.6 100
With an analytical recovery rate of > 80 %, no transformation of the nominal EC-values into the values of the concentration control analysis occurs. ANALYTICAL RESULTS0h expected concentration in sample: 0 mg/L value found: <5 mg/L0h expected concentration in sample: 12.5 mg/L value found: 12.5 mg/L0h expected concentration in sample: 100 mg/L value found: 100 mg/L48h expected concentration in sample: 0 mg/L value found: <5 mg/L48h expected concentration in sample: 12.5 mg/L value found: 12.2 mg/L48h expected concentration in sample: 100 mg/L value found: 100 mg/L
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.