Registration Dossier
Registration Dossier
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EC number: 700-042-6 | CAS number: 177997-13-6
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
- The registered substance, Lithium Cobalt Nickel Aluminium Oxide is a unique chemical substance and does not contain nickel or cobalt in the specific form of any of the carcinogenic substances referred to above. Therefore reference to these substances and their classification should be carefully considered in conjunction with existing information on the substance itself.
- The existing in vitro data, obtained from multiple studies conducted according to OECD guidelines and under GLP conditions, clearly show that Lithium Cobalt Nickel Aluminum Oxide does not express any mutagenic or clastogenic effects under the conditions of those tests.
- To date there are insufficient adequate data available to make wholly conclusive statements as to the carcinogenic potential of the substance, although all the existing in vitro mutagenicity data on the substance itself indicate a negative response
Some concerns are expressed towards the carcinogenic potential of Lithium Cobalt Nickel Aluminium Oxide, due to the classification of some of the metals and metal oxides present in the substance as carcinogenic substances. In particular nickel (EC 231-111-4) is classified as a category 2 carcinogen, while nickel monoxide (EC 215-215-7), nickel dioxide (EC 234-823-3), cobalt nickel dioxide (EC261-346-8) and cobalt lithium nickel oxide (EC 442-750-5) are classified as category 1A carcinogens according to Annex VI of the CLP regulation.
The registrant, however, would like to point out that the classification of Lithium Cobalt Nickel Aluminium Oxide as a carcinogenic substance is a conservative approach:
Additional information
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