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EC number: 603-501-8 | CAS number: 13171-18-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 January 2019 thru 25 January 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Remarks:
- Extra care was taken to prevent volatilization of substance.
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Reference ID: Propane, 1, 1, 1, 3, 3, 3-hexafluoro-2-methoxy- / CAS No. 13171-18-1
Label ID: 1,1,1,3,3,3,-HEXAFLUORO-2-METHOXYPROPANE-CAS NO.: 13171-18-1
LOT #: 17004
Date & Qty. Received: 06 Nov 18; 65.1 g (GW)
Physical Description: Clear liquid
Storage: Room temperature - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0, 6.25, 12.5, 25, 50, 100 mg/L
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
Method: The definitive stock solution was prepared by using a gas tight syringe to introduce 370 µL of test substance in 2000 mL of dilution water, stoppered and stirred vigorously for 15 minutes. This stock solution was diluted with dilution water to make five different test substance solutions with five different concentrations for the definitive test. Solutions for the definitive test were prepared from the stock solution and stirred vigorously for 15 minutes after preparation.
Controls: dilution water only.
Chemical name of vehicle (organic solvent, emulsifier or dispersant): none
Concentration of vehicle in test medium (stock solution and final test solution(s) or suspension(s) including control(s)): not applicable
Evidence of undissolved material (e.g. precipitate, surface film, etc.): none - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain/clone: not applicable
- Justification for species other than prescribed by test guideline: One of the daphnid species specified in the OCSPP regulations.
- Source: STILLMEADOW, Inc. culture laboratory
- Age of parental stock (mean and range, SD): No greater than 24 hours old at dosing
- Feeding during test:
- Food type:
- Amount:
- Frequency:
ACCLIMATION
- Acclimation period: 48 hours
- Acclimation conditions (same as test or not): yes
- Type and amount of food: none
- Feeding frequency: not applicable
- Health during acclimation (any mortality observed): none
METHOD FOR PREPARATION AND COLLECTION OF EARLY INSTARS OR OTHER LIFE STAGES: Not applicable - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- none
- Hardness:
- 235 mg/L CaCO3
- Test temperature:
- 21 deg C
- pH:
- 7.7
- Dissolved oxygen:
- 91 - 98%
- Salinity:
- Not applicable
- Conductivity:
- 641 - 686 umhos/cm
- Nominal and measured concentrations:
- Nominal: 6.25, 12.5, 25, 50, 100 mg/L. To account for volatilization losses during preparation and sampling of solutions, nominal dose concentrations were calculated based on an active of 40% concentration and a density of 1.38 g/mL.
Measured (at start): ND, 49.9, 56.1, 72.8, and 125.7 mg/L; where ND=Non Detected
Measured (at 24 hours old): ND, ND, 44.1, 56.5, and 60.0 mg/L; where ND=Non Detected
Measured (at 48 hours old): ND, ND, 39.2, 43.6, and 44.5 mg/L; where ND=Non Detected - Details on test conditions:
- TEST SYSTEM
- Test vessel: 250 mL glass beakers
- Type (delete if not applicable): closed/stoppered
- Headspace: minimized to greatest extent possible.
- Aeration: No
- Type of flow-through (e.g. peristaltic or proportional diluter): Not applicable
- Renewal rate of test solution (frequency/flow rate): Not applicable
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): not applicable
- Biomass loading rate: not applicable
OTHER TEST CONDITIONS
- Adjustment of pH: 7.7
- Photoperiod: 12 hours
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): Mortality and other abnormalities at 0 hours, 24 hours, and 48 hours.
VEHICLE CONTROL PERFORMED: not applicable
RANGE-FINDING STUDY
- Test concentrations: 0.01, 0.1, 1, 10, and 100 mg/L.
- Results used to determine the conditions for the definitive study: no mortality at any concentration. - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- Measured concentration at time zero was 125.7 mg/L
- Basis for effect:
- mortality
- Details on results:
- - Behavioural abnormalities: Yes, animals sunk to the bottom and movements were abnormal but this effect is believed to be the result of a reduction in the surface tension of the test solution.
- Observations on body length and weight: Not determined
- Mortality of control: 10%
- Other adverse effects control: None reported.
- Abnormal responses: Animals sunk to the bottom and movements were abnormal but this effect is believed to be the result of a reduction in the surface tension of the test solution.
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: Yes, substance volatilizes rapidly from water.
- Effect concentrations exceeding solubility of substance in test medium: No - Validity criteria fulfilled:
- yes
- Conclusions:
- The 48-hour LC50 for Daphnia magna is >100 mg/L.
- Executive summary:
In a GLP guideline study conducted according to OECD Method 202, Daphnia magna were exposed to the test substance under static conditions in tightly sealed containers at nominal concentrations of 0, 6.25, 12.5, 25, 50, and 100 mg/L (measured concentrations at time zero were ND, 49.9, 56.1, 72.8, and 125.7 mg/L where ND=Not Detected). No Mortalities were observed at the top doses and mortalities at lower doses were not statistically different from controls. Observed abnormalities included animals sunk to the bottom and movements were abnormal but this effect is believed to be the result of a reduction in the surface tension of the test solution and has been reported with other fluorinated hydrocarbons. As expected, the substance was found to easily volatilze from water despite taking great care to minimize these losses. Based on these results, the 48 -hour LC50 for Daphnia magna is >100 mg/L and can be considered to not pose a danger in the aquatic environment.
Reference
Definitive Test Mortality Results:
Concentration (mg/L)* |
Replicate |
Number of Surviving Organisms** |
Mortality (%) |
||
0 hours |
24 hours |
48 hours |
|||
Control |
A |
5 |
5 |
3 |
10 |
B |
5 |
5 |
5 |
||
C |
5 |
5 |
5 |
||
D |
5 |
5 |
5 |
||
6.25 |
A |
5 |
5 |
4 |
5 |
B |
5 |
5 |
5 |
||
C |
5 |
5 |
5 |
||
D |
5 |
5 |
5 |
||
12.5 |
A |
5 |
5 |
5 |
0 |
B |
5 |
5 |
5 |
||
C |
5 |
5 |
5 |
||
D |
5 |
5 |
5 |
||
25 |
A |
5 |
3 |
3 |
15 |
B |
5 |
5 |
5 |
||
C |
5 |
5 |
5 |
||
D |
5 |
5 |
4 |
||
50 |
A |
5 |
4 |
5 |
0 |
B |
5 |
3 |
5 |
||
C |
5 |
3 |
5 |
||
D |
5 |
4 |
5 |
||
100 |
A |
5 |
4 |
5 |
0 |
B |
5 |
4 |
5 |
||
C |
5 |
3 |
5 |
||
D |
5 |
3 |
5 |
*Nominal
**Some animals reported as dead recovered later. At higher concentrations, organisms sunk to the bottom and began to twitch or were sluggish but otherwise looked normal. Some only moved when prompted.
Description of key information
In a GLP guideline study conducted according to OECD Method 202, Daphnia magna were exposed to the test substance under static conditions in tightly sealed containers at nominal concentrations of 0, 6.25, 12.5, 25, 50, and 100 mg/L (measured concentrations at time zero were ND, 49.9, 56.1, 72.8, and 125.7 mg/L where ND=Not Detected). No Mortalities were observed at the top doses and mortalities at lower doses were not statistically different from controls. Observed abnormalities included animals sunk to the bottom and movements were abnormal but this effect is believed to be the result of a reduction in the surface tension of the test solution and has been reported with other fluorinated hydrocarbons. As expected, the substance was found to easily volatilze from water despite taking great care to minimize these losses. Based on these results, the 48 -hour LC50 forDaphnia magnais >100 mg/L and can be considered to not pose a danger in the aquatic environment.
Key value for chemical safety assessment
Additional information
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